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  2. SDC4 - syndecan 4 Gene

SDC4 - syndecan 4 Gene

中文名称:联癸烷 4

种属: Homo sapiens

同用名: SYND4

基因 ID: 6385 | 基因类型: protein coding

关于 SDC4

Cytogenetic location: 20q13.12 Genomic coordinates (GRCh38): 20:45,325,288-45,348,424 (from NCBI)

This gene has 1 transcript (splice variant), 197 orthologues, 3 paralogues and is associated with 48 phenotypes. Broad expression in liver (RPKM 189.5), lung (RPKM 100.6) and 23 other tissues.

功能概要

由该基因编码的蛋白质是一种跨膜 (I 型) 硫酸乙酰肝素蛋白多糖,在细胞内信号传导中起着受体的作用。编码的蛋白质被发现为同源二聚体,并且是聚糖蛋白聚糖家族的成员。该基因位于 20 号染色体上,而假基因位于 22 号染色体上。[RefSeq 提供,2008 年 7 月]

The protein encoded by this gene is a transmembrane (type I) heparan sulfate proteoglycan that functions as a receptor in intracellular signaling. The encoded protein is found as a homodimer and is a member of the syndecan proteoglycan family. This gene is found on chromosome 20, while a pseudogene has been found on chromosome 22. [provided by RefSeq, Jul 2008]

SDC4 基因产物(1)

mRNA Protein Name
NM_002999.4 NP_002990.2 syndecan-4 precursor
基因本体论
  • 分子功能
  • 生物过程
分子功能 GO 注释 逻辑证据 参考文献 来源
enables identical protein binding IPI
IPI: 通过物理相互作用推断
18093920 GOA
enables protein binding IPI
IPI: 通过物理相互作用推断
12571249 GOA
enables thrombospondin receptor activity IMP
IMP: 通过突变表型推断
17879962 GOA
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in negative regulation of T cell proliferation IMP
IMP: 通过突变表型推断
19350579 GOA
involved in positive regulation of exosomal secretion IMP
IMP: 通过突变表型推断
22660413 GOA
involved in positive regulation of extracellular exosome assembly IMP
IMP: 通过突变表型推断
22660413 GOA
EXP:通过实验结果推断 IDA:通过直接分析推断 IPI:通过物理相互作用推断 IMP:通过突变表型推断 IGI:通过遗传相互作用推断 IEP:通过表达模式推断

SDC4 蛋白结构

Syndecan

Syndecan: Syndecan domain (138 - 196)

  • 0
  • 100
  • 198 a.a.
蛋白主名 其他名称

syndecan-4

amphiglycan

SDC4 蛋白互作信息

分类
蛋白名称 蛋白编号 互作蛋白 互作蛋白种属 互作蛋白编号 实验方法 参考文献
种属内
SDC4 P31431 SDC2 Homo sapiens P34741
Comigration in Gel
18093920
种属内
SDC4 P31431 PRKCA Homo sapiens P17252
Pull Down
12571249
种属内
SDC4 P31431 SDC3 Homo sapiens O75056
Comigration in Gel
18093920
种属内
SDC4 P31431 PMP22 Homo sapiens Q01453
Validated Y2H
32296183
种属内
SDC4 P31431 SGTA Homo sapiens O43765
Y2H Prey Pooling
25416956
种属内
SDC4 P31431 SGTA Homo sapiens O43765
Validated Y2H
25416956
种属内
SDC4 P31431 SGTA Homo sapiens O43765
Y2H Prey Pooling
32296183
种属内
SDC4 P31431 SGTA Homo sapiens O43765
Y2H Array
32296183
种属内
SDC4 P31431 SGTA Homo sapiens O43765
Y2H Array
25416956
种属内
SDC4 P31431 SGTB Homo sapiens Q96EQ0
Validated Y2H
32296183
种属内
SDC4 P31431 SGTB Homo sapiens Q96EQ0
Y2H Array
32296183
种属内
SDC4 P31431 SGTB Homo sapiens Q96EQ0
Y2H Prey Pooling
32296183
种属内
SDC4 P31431 IL7R Homo sapiens P16871
Y2H Prey Pooling
32296183
种属内
SDC4 P31431 IL7R Homo sapiens P16871
Y2H Array
32296183
种属间: 跨种属相互作用 种属内: 同种属相互作用

重组 SDC4 蛋白

目录号 产品名 蛋白编号 纯度
HY-P73623 Syndecan-4 Protein, Human (HEK293, His) P31431-1 (E19-E145) ≥95%

关联疾病

疾病名称 别名
Thyroid Carcinoma

Thyroid Cancer

Malignant Neoplasm Of Thyroid

Thyroid Neoplasm

Achromatopsia 7

ACHM7

Achromatopsia, Type 7

疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

直系同源

种属 基因名 来源 基因 ID
Macaca mulatta SDC4 VGNC VGNC:98441
Canis familiaris SDC4 VGNC VGNC:45944
Mus musculus SDC4 MGD MGI:1349164
Rattus norvegicus SDC4 RGD RGD:3650
Bos taurus SDC4 VGNC VGNC:34381
Felis catus SDC4 VGNC VGNC:64946
Others SDC4 NCBI