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  3. Pde10a - phosphodiesterase 10A Gene

Pde10a - phosphodiesterase 10A Gene

  • 基因
  • 蛋白
  • 相关产品
  • 直系同源

中文名称：磷酸二酯酶 10A

种属: Rattus norvegicus

同用名: Pde10a3

基因 ID: 63885 | 基因类型: protein coding

关于 Pde10a

Primary_assembly 1: 51,770,132-52,216,563 reverse strand.mRatBN7.2:CM026974.1

This gene has 7 transcripts (splice variants), 207 orthologues, 20 paralogues and is associated with 4 phenotypes. Biased expression in Brain (RPKM 161.1), Adrenal (RPKM 82.4) and 6 other tissues.

功能概要

该基因编码的蛋白可启动环核苷酸磷酸二酯酶活性。参与 cAMP 介导的信号传导的负调节和 cGMP 介导的信号传导的负调节。位于膜和核周。与人 PDE10A（磷酸二酯酶 10A）同源。 [由基因组资源联盟提供，2022 年 4 月]

Enables cyclic-nucleotide phosphodiesterase activity. Involved in negative regulation of cAMP-mediated signaling and negative regulation of cGMP-mediated signaling. Located in membrane and perikaryon. Orthologous to human PDE10A (phosphodiesterase 10A). [provided by Alliance of Genome Resources, Apr 2022]

Pde10a 基因产物(4)

mRNA Protein Name
NM_001388510.1 NP_001375439.1 cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A isoform 2
NM_022236.2 NP_071572.1 cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A isoform 1
NM_001388509.1 NP_001375438.1 cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A isoform 2
NM_001388511.1 NP_001375440.1 cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A isoform 3

Pde10a 蛋白结构

GAF

GAF: pfam01590 (381 - 524)

GAF

GAF: smart00065 (557 - 712)

PDEase_I

PDEase_I: pfam00233 (804 - 1035)

  • 0
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  • 1000
  • 1075 a.a.
蛋白主名 其他名称

cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A

testis-specific phosphodiesterase PDE10A2

相关产品

Clinical Phase
生物活性分子 (3)
目录号 产品名 作用方式
纯度 Phase
HY-12472 Balipodect Inhibitor 99.47% Phase 2
HY-112831 Osoresnontrine Inhibitor 99.88% Phase 2
HY-50098A Mardepodect hydrochloride Inhibitor 99.94% Phase 2
Pre-clinical Phase
生物活性分子 (22)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-50098 Mardepodect Inhibitor 99.04% 否
HY-153093 MK-8189 Inhibitor 99.88% 否
HY-14550 TP-10 Inhibitor 99.88% 否
HY-117604 THPP-1 Inhibitor 98.75% 否
HY-18078 PQ-10 Inhibitor 99.77% 否
HY-12913 AMG 579 Inhibitor 99.02% 否
HY-131973 PDE10A-IN-2 hydrochloride Inhibitor 98.43% 否
HY-135848 N-Methylbenzamide Inhibitor 99.93% 否
HY-10568 TC-E 5005 Inhibitor / 否
HY-123743 JNJ-42314415 Inhibitor / 否
HY-152838 Gemlapodect Inhibitor / 否
HY-158237 PDE10A-IN-3 Inhibitor / 否
HY-160111 PDM-042 Inhibitor / 否
HY-161663 Phosphodiesterase-IN-2 Inhibitor / 否
HY-18037 AMG-7980 / 否
HY-RS10199 PDE10A Human Pre-designed siRNA Set A Pre-designed Sets / 否
HY-RS10200 Pde10a Mouse Pre-designed siRNA Set A Pre-designed Sets / 否
HY-RS10201 Pde10a Rat Pre-designed siRNA Set A Pre-designed Sets / 否
HY-10030 Mardepodect succinate / 否
HY-117838 Phosphodiesterase 10-IN-2 Inhibitor / 否
HY-123154 PDE10A-IN-4 / 否
HY-112704 PDE5-IN-2 Inhibitor / 否

直系同源

种属 基因名 来源 基因 ID
Homo sapiens Pde10a NCBI NCBI:10846
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