Casp8 - caspase 8 Gene

中文名称：半胱天冬酶 8

种属: Rattus norvegicus

同用名: CASP-8

关于 Casp8

功能概要

该基因编码的蛋白可启动半胱氨酸型内肽酶活性；死亡受体结合活性；和肿瘤坏死因子受体结合活性。参与几个过程，包括对雌二醇的反应；对乙醇的反应；和对脂多糖的反应。位于多个细胞成分中，包括细胞体；胞质溶胶；和膜筏。 CD95 死亡诱导信号复合体的一部分。用于研究恶变前的肿瘤。多种疾病的生物标志物，包括心脏病（多种）；肾脏疾病（多发）；视网膜脱离;坐骨神经病;和癫痫持续状态。该基因的人类直系同源物与自身免疫性淋巴组织增生性综合征 2B 型有关；乳腺癌;内分泌腺癌（多发）；食道腺癌；和原发性免疫缺陷病。与人类 CASP8（caspase 8）同源。 [由基因组资源联盟提供，2022 年 4 月]

Enables cysteine-type endopeptidase activity; death receptor binding activity; and tumor necrosis factor receptor binding activity. Involved in several processes, including response to estradiol; response to ethanol; and response to lipopolysaccharide. Located in several cellular components, including cell body; cytosol; and membrane raft. Part of CD95 death-inducing signaling complex. Used to study pre-malignant neoplasm. Biomarker of several diseases, including heart disease (multiple); kidney disease (multiple); retinal detachment; sciatic neuropathy; and status epilepticus. Human ortholog(s) of this gene implicated in autoimmune lymphoproliferative syndrome type 2B; breast cancer; endocrine gland Cancer (multiple); esophagus adenocarcinoma; and primary immunodeficiency disease. Orthologous to human CASP8 (Caspase 8). [provided by Alliance of Genome Resources, Apr 2022]