2. Gene
  3. ARHGAP9 - Rho GTPase activating protein 9 Gene

ARHGAP9 - Rho GTPase activating protein 9 Gene

  • 基因
  • 蛋白
  • 相关产品
  • 直系同源

中文名称：Rho GTP 酶激活蛋白 9

种属: Homo sapiens

同用名: 10C; RGL1

基因 ID: 64333 | 基因类型: protein coding

关于 ARHGAP9

Cytogenetic location: 12q13.3 Genomic coordinates (GRCh38): 12:57,472,269-57,488,824 (from NCBI)

This gene has 24 transcripts (splice variants), 198 orthologues and 3 paralogues. Broad expression in spleen (RPKM 23.2), bone marrow (RPKM 22.4) and 14 other tissues.

功能概要

该基因编码 GTP 酶激活蛋白 Rho-GAP 家族的一个成员。该蛋白在体外对几种 Rho 家族 GTP 酶具有显着的 GAP 活性，将它们转化为无活性的 GDP 结合状态。它涉及调节造血细胞与细胞外基质的粘附。已发现该基因编码不同异构体的多个转录变体。[RefSeq 提供，2008 年 7 月]

This gene encodes a member of the Rho-GAP family of GTPase activating proteins. The protein has substantial GAP activity towards several Rho-family GTPases in vitro, converting them to an inactive GDP-bound state. It is implicated in regulating adhesion of hematopoietic cells to the extracellular matrix. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

ARHGAP9 基因产物(11)

mRNA Protein Name
NM_001080156.3 NP_001073625.1 rho GTPase-activating protein 9 isoform 3
NM_001080157.2 NP_001073626.1 rho GTPase-activating protein 9 isoform 2
NM_001319850.2 NP_001306779.2 rho GTPase-activating protein 9 isoform 4
NM_001319851.2 NP_001306780.1 rho GTPase-activating protein 9 isoform 5
NM_001319852.2 NP_001306781.1 rho GTPase-activating protein 9 isoform 6
NM_001367422.1 NP_001354351.1 rho GTPase-activating protein 9 isoform 7
NM_001367423.1 NP_001354352.1 rho GTPase-activating protein 9 isoform 8
NM_001367424.1 NP_001354353.1 rho GTPase-activating protein 9 isoform 9
NM_001367425.1 NP_001354354.1 rho GTPase-activating protein 9 isoform 10
NM_001367426.1 NP_001354355.1 rho GTPase-activating protein 9 isoform 3
NM_032496.4 NP_115885.2 rho GTPase-activating protein 9 isoform 1
基因本体论
  • 分子功能
分子功能 GO 注释 逻辑证据 参考文献 来源
enables GTPase activator activity IDA
IDA: 通过直接分析推断
11396949 GOA
enables phosphatidylinositol-3,4,5-trisphosphate binding IDA
IDA: 通过直接分析推断
17339315 GOA
enables protein binding IPI
IPI: 通过物理相互作用推断
25416956 GOA
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

ARHGAP9 蛋白结构

SH3_1

SH3_1: SH3 domain (29 - 67)

PH

PH: PH domain (324 - 434)

RhoGAP

RhoGAP: RhoGAP domain (537 - 705)

  • 0
  • 200
  • 400
  • 600
  • 731 a.a.
蛋白主名 其他名称

rho GTPase-activating protein 9

rho-type GTPase-activating protein 9

ARHGAP9 蛋白互作信息

分类
蛋白名称 蛋白编号 互作蛋白 互作蛋白种属 互作蛋白编号 实验方法 参考文献
种属内
ARHGAP9 Q9BRR9 GOLGA6A Homo sapiens Q9NYA3
Validated Y2H
32296183
种属内
ARHGAP9 Q9BRR9 GOLGA6A Homo sapiens Q9NYA3
Y2H Array
32296183
种属内
ARHGAP9 Q9BRR9 GOLGA6A Homo sapiens Q9NYA3
Y2H Prey Pooling
32296183
种属内
ARHGAP9 Q9BRR9 CYSRT1 Homo sapiens A8MQ03
Y2H Prey Pooling
32296183
种属内
ARHGAP9 Q9BRR9 CYSRT1 Homo sapiens A8MQ03
Y2H Array
32296183
种属内
ARHGAP9 Q9BRR9 GRB2 Homo sapiens P62993
Y2H Array
25416956
种属内
ARHGAP9 Q9BRR9 GOLGA6L9 Homo sapiens A6NEM1
Y2H Array
32296183
种属内
ARHGAP9 Q9BRR9 GOLGA6L9 Homo sapiens A6NEM1
Y2H Prey Pooling
32296183
种属内
ARHGAP9 Q9BRR9 FHL2 Homo sapiens Q14192
Y2H Array
25416956
种属内
ARHGAP9 Q9BRR9 MRPL38 Homo sapiens Q96DV4
Y2H Prey Pooling
32296183
种属内
ARHGAP9 Q9BRR9 MRPL38 Homo sapiens Q96DV4
Y2H Array
32296183
种属内
ARHGAP9 Q9BRR9 TSC22D4 Homo sapiens Q9Y3Q8
Y2H Array
32296183
种属内
ARHGAP9 Q9BRR9 TSC22D4 Homo sapiens Q9Y3Q8
Validated Y2H
32296183
种属内
ARHGAP9 Q9BRR9 TSC22D4 Homo sapiens Q9Y3Q8
Y2H Prey Pooling
32296183
种属内
ARHGAP9 Q9BRR9 ABI3 Homo sapiens Q9P2A4
Y2H Array
32296183
种属内
ARHGAP9 Q9BRR9 ABI3 Homo sapiens Q9P2A4
Y2H Prey Pooling
32296183
种属内
ARHGAP9 Q9BRR9 ABI3 Homo sapiens Q9P2A4
Validated Y2H
32296183
种属内
ARHGAP9 Q9BRR9 NME7 Homo sapiens Q9Y5B8
Validated Y2H
32296183
种属间: 跨种属相互作用 种属内: 同种属相互作用

相关产品

Pre-clinical Phase
生物活性分子 (1)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-RS00942 ARHGAP9 Human Pre-designed siRNA Set A Pre-designed Sets / 否

直系同源

种属 基因名 来源 基因 ID
Macaca mulatta ARHGAP9 VGNC VGNC:69826
Rattus norvegicus ARHGAP9 RGD RGD:1305342
Bos taurus ARHGAP9 VGNC VGNC:26100
Felis catus ARHGAP9 VGNC VGNC:59895
Mus musculus ARHGAP9 MGD MGI:2143764
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