Ctsb - cathepsin B Gene

中文名称：组织蛋白酶 B

种属: Rattus norvegicus

关于 Ctsb

功能概要

该基因编码的蛋白可启动多种功能，包括半胱氨酸型内肽酶活性；激肽原结合活性；和蛋白质自缔合。涉及多个过程，包括细胞对机械刺激的反应；对乙醇的反应；和对 interleukin-4 的反应。位于几种细胞成分中，包括顶端质膜；质膜的外侧；和肌膜。与细胞质的小窝和核周区域共定位。用于研究肝细胞癌和高级别胶质瘤。多种疾病的生物标志物，包括急性坏死性胰腺炎；脑血管疾病（多发）；片形吸虫病；脂肪肝病；和肾小管性酸中毒。该基因的人类直系同源物与糖尿病有关。与人 CTSB（组织蛋白酶 B）同源。 [由基因组资源联盟提供，2022 年 4 月]

Enables several functions, including cysteine-type endopeptidase activity; kininogen binding activity; and protein self-association. Involved in several processes, including cellular response to mechanical stimulus; response to ethanol; and response to interleukin-4. Located in several cellular components, including apical plasma membrane; external side of plasma membrane; and sarcolemma. Colocalizes with caveola and perinuclear region of cytoplasm. Used to study hepatocellular carcinoma and high grade glioma. Biomarker of several diseases, including acute necrotizing pancreatitis; cerebrovascular disease (multiple); fascioliasis; fatty liver disease; and renal tubular acidosis. Human ortholog(s) of this gene implicated in diabetes mellitus. Orthologous to human CTSB (Cathepsin B). [provided by Alliance of Genome Resources, Apr 2022]