2. Gene
  3. Il12b - interleukin 12B Gene

Il12b - interleukin 12B Gene

  • 基因
  • 蛋白
  • 相关产品
  • 直系同源

中文名称：白细胞介素 12B

种属: Rattus norvegicus

同用名: Il12

基因 ID: 64546 | 基因类型: protein coding

关于 Il12b

Primary_assembly 10: 28,893,008-28,902,903 forward strand.mRatBN7.2:CM026983.1

This gene has 1 transcript (splice variant), 268 orthologues and is associated with 29 phenotypes. Biased expression in Thymus (RPKM 25.2), Spleen (RPKM 18.6) and 1 other tissue.

功能概要

该基因编码的蛋白可启动白细胞介素 12 α 亚基结合活性。参与参与免疫反应和疼痛感觉的自然杀伤细胞激活。位于细胞外空间。白细胞介素 12 复合体的一部分。与哮喘有关的该基因的人类直系同源物；慢性阻塞性肺疾病;免疫缺陷 29；和沙门氏菌病。与人 IL12B（白细胞介素 12B）同源。 [由基因组资源联盟提供，2022 年 4 月]

Enables interleukin-12 alpha subunit binding activity. Involved in natural killer cell activation involved in immune response and sensory perception of pain. Located in extracellular space. Part of interleukin-12 complex. Human ortholog(s) of this gene implicated in asthma; chronic obstructive pulmonary disease; immunodeficiency 29; and salmonellosis. Orthologous to human IL12B (interleukin 12B). [provided by Alliance of Genome Resources, Apr 2022]

Il12b 基因产物(1)

mRNA Protein Name
NM_022611.2 NP_072133.2 interleukin-12 subunit beta precursor

Il12b 蛋白结构

Ig_3

Ig_3: pfam13927 (41 - 89)

Ig

Ig: cd00096 (45 - 49)

Ig

Ig: cd00096 (56 - 60)

Ig

Ig: cd00096 (74 - 78)

Ig

Ig: cd00096 (86 - 91)

IL12p40_C

IL12p40_C: pfam10420 (122 - 213)

FN3

FN3: cd00063 (232 - 269)

  • 0
  • 100
  • 200
  • 300
  • 335 a.a.
蛋白主名 其他名称

interleukin-12 subunit beta

interleukin-12 p40

重组 Il12b 蛋白

目录号 产品名 蛋白编号 纯度
HY-P7370 IL-12 Protein, Rat (CHO) Q9R103 (R23-S215)&E9PU71 (M23-S335) ≥95%
HY-P72598 IL-12 Protein, Rat (HEK293, His) Q9R103 (R23-S215)&Q9R278 (M23-S335) ≥95%
HY-P73164 IL-12 beta Protein, Rat (HEK293, His) E9PU71 (M23-S335) ≥95%
HY-P73195 IL-23 alpha & IL-12 beta Heterodimer Protein, Rat (HEK293, His) NP_569094.1 (V22-A196) & EDM04146.1 (M23-S335) ≥95%
HY-P74835 IL-12 beta Protein, Rat (HEK293, Fc) E9PU71 (M23-S335) ≥95%

相关产品

Pre-clinical Phase
生物活性分子 (3)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-RS06680 IL12B Human Pre-designed siRNA Set A Pre-designed Sets / 否
HY-RS06681 Il12b Mouse Pre-designed siRNA Set A Pre-designed Sets / 否
HY-RS06682 Il12b Rat Pre-designed siRNA Set A Pre-designed Sets / 否

直系同源

种属 基因名 来源 基因 ID
Homo sapiens Il12b NCBI NCBI:3593
Mus musculus Il12b NCBI NCBI:16160
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