2. Gene
  3. Il12b - interleukin 12b Gene

Il12b - interleukin 12b Gene

  • 基因
  • 蛋白
  • 相关产品
  • 直系同源

中文名称：白细胞介素 12 b

种属: Mus musculus

同用名: p40; Il-12b; Il12p40; Il-12p40

基因 ID: 16160 | 基因类型: protein coding

关于 Il12b

Chromosome 11: 44,290,890-44,304,860 forward strand.GRCm39:CM001004.3

This gene has 2 transcripts (splice variants), 268 orthologues and is associated with 19 phenotypes. Biased expression in thymus adult (RPKM 1.), spleen adult (RPKM .3) and 4 other tissues.

功能概要

该基因编码白细胞介素 12 (IL-12) 细胞因子家族的 β 亚基 p40。 IL-12 家族的成员形成由二硫键连接的重亚基和轻亚基组成的异二聚体。该基因的产物 p40 是白细胞介素 IL-12 和 IL-23 的一个亚基。 [RefSeq 提供，2014 年 12 月]

This gene encodes the beta subunit p40 of the Interleukin 12 (IL-12) family of cytokines. Members of the IL-12 family form heterodimers consisting of heavy and light subunits linked by disulfide bonds. The product of this gene, p40, is a subunit of interleukins IL-12 and IL-23. [provided by RefSeq, Dec 2014]

Il12b 基因产物(1)

mRNA Protein Name
NM_001303244.1 NP_001290173.1 interleukin-12 subunit beta precursor
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
contributes to cytokine activity IDA
IDA: 通过直接分析推断
11057672 MGI
contributes to cytokine receptor binding IPI
IPI: 通过物理相互作用推断
11114383 MGI
enables identical protein binding IPI
IPI: 通过物理相互作用推断
12871593 MGI
enables interleukin-12 alpha subunit binding IPI
IPI: 通过物理相互作用推断
15220916 MGI
enables protein binding IPI
IPI: 通过物理相互作用推断
11114383 MGI
生物过程 GO 注释 逻辑证据 参考文献 来源
acts upstream of T cell proliferation IDA
IDA: 通过直接分析推断
11057672 MGI
acts upstream of or within T-helper 1 cell cytokine production IGI
IGI: 通过遗传相互作用推断
15843532 MGI
acts upstream of or within cell population proliferation IDA
IDA: 通过直接分析推断
15843532 MGI
acts upstream of or within cell population proliferation IGI
IGI: 通过遗传相互作用推断
15843532 MGI
acts upstream of or within cell surface receptor signaling pathway IDA
IDA: 通过直接分析推断
12871593 MGI
acts upstream of or within cellular response to lipopolysaccharide IDA
IDA: 通过直接分析推断
18025219 MGI
acts upstream of or within cellular response to type II interferon IDA
IDA: 通过直接分析推断
18025219 MGI
acts upstream of or within defense response to protozoan IDA
IDA: 通过直接分析推断
19050265 MGI
acts upstream of or within defense response to protozoan IGI
IGI: 通过遗传相互作用推断
9348310 MGI
acts upstream of or within defense response to protozoan IMP
IMP: 通过突变表型推断
9348310 MGI
acts upstream of or within defense response to virus IDA
IDA: 通过直接分析推断
17277142 MGI
acts upstream of or within negative regulation of inflammatory response to antigenic stimulus IMP
IMP: 通过突变表型推断
16949315 MGI
involved in positive regulation of T cell mediated cytotoxicity IDA
IDA: 通过直接分析推断
14688363 MGI
acts upstream of or within positive regulation of T cell proliferation IDA
IDA: 通过直接分析推断
11057672 MGI
involved in positive regulation of T-helper 1 type immune response IDA
IDA: 通过直接分析推断
14688363 MGI
involved in positive regulation of defense response to virus by host IDA
IDA: 通过直接分析推断
14688363 MGI
acts upstream of or within positive regulation of type II interferon production IDA
IDA: 通过直接分析推断
21444916 MGI
acts upstream of or within positive regulation of type II interferon production IGI
IGI: 通过遗传相互作用推断
9348310 MGI
acts upstream of or within positive regulation of type II interferon production IMP
IMP: 通过突变表型推断
16949315 MGI
acts upstream of type II interferon production IDA
IDA: 通过直接分析推断
21444916 MGI
acts upstream of type II interferon production IGI
IGI: 通过遗传相互作用推断
9348310 MGI
细胞组分 GO 注释 逻辑证据 参考文献 来源
located in cell surface IDA
IDA: 通过直接分析推断
20818394 MGI
located in cytoplasm IDA
IDA: 通过直接分析推断
11737071 MGI
located in extracellular space IDA
IDA: 通过直接分析推断
7690439 MGI
part of interleukin-12 complex IDA
IDA: 通过直接分析推断
15220916 MGI
part of interleukin-12 complex IGI
IGI: 通过遗传相互作用推断
7690439 MGI
part of interleukin-23 complex IDA
IDA: 通过直接分析推断
11114383 MGI
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

Il12b 蛋白结构

Ig_3

Ig_3: pfam13927 (31 - 89)

Ig

Ig: cd00096 (45 - 49)

Ig

Ig: cd00096 (55 - 59)

Ig

Ig: cd00096 (72 - 76)

IL12p40_C

IL12p40_C: pfam10420 (122 - 213)

  • 0
  • 100
  • 200
  • 300
  • 335 a.a.
蛋白主名 其他名称

interleukin-12 subunit beta

CLMF p40

IL-12 p40 subunit

IL-12 subunit p40

IL-23 subunit p40

cytotoxic lymphocyte maturation factor 40 kDa subunit

interleukin-12 p40 subunit

重组 Il12b 蛋白

目录号 产品名 蛋白编号 纯度
HY-P7208 IL-12 Protein, Mouse (CHO) P43431 (R23-A215) & P43432 (M23-S335) ≥95%
HY-P70421 IL-23 alpha (175a.a) & IL-12 beta (313a.a) Heterodimer Protein, Mouse (Sf9) Q9EQ14 (V22-A196)&P43432 (M23-S335 ) ≥95%
HY-P70604 IL-23 alpha (175a.a) & IL-12 beta (313a.a) Heterodimer Protein, Mouse (HEK293, C-His) Q9EQ14 (V22-A196)&P43432 (M23-S335) ≥95%
HY-P70666 IL-12 Protein, Mouse (HEK293) P43431 (R23-A215) & P43432 (M23-S335) ≥95%
HY-P70709 IL-23 alpha (175a.a) & IL-12 beta (313a.a) Heterodimer Protein, Mouse (HEK293) Q9EQ14 (V22-A196)&P43432 (M23-S335) ≥95%
HY-P72597 IL-12 beta Protein, Mouse (HEK293, His) P43432 (M23-S335) ≥95%
HY-P73158 IL-12 Protein, Mouse (HEK293, His-Fc) P43431 (R23-A215) & P43432 (M23-S335) ≥95%
HY-P73159 IL-12 Protein, Mouse (HEK293, His) P43431 (R23-A215) & P43432 (M23-S335) ≥95%
HY-P73161 IL-12 beta Protein, Mouse (HEK293) P43432 (M23-S335) ≥95%
HY-P73162 IL-12 beta Protein, Mouse (HEK293, Fc) P43432 (M23-S335) ≥95%
HY-P73157 IL-12 Protein, Mouse (HEK293, Fc) P43431 (R23-A215) & P43432 (M23-S335) ≥95%
HY-P74874 Human IL-23 alpha & Mouse IL-12 beta Heterodimer Protein (HEK293, His) Q9NPF7 (R20-P189)&P43432 (M23-S335) ≥95%
HY-P77703 Cynomolgus IL-23 alpha & Mouse IL-12 beta Heterodimer Protein (HEK293, His) A0A2K5TLV4 (V22-P189)&P43432 (M23-S335) ≥95%
HY-P77712 Human IL-23 alpha & Mouse IL-12 beta Heterodimer Protein (HEK293, His-Avi) Q9NPF7 (R20-P189)&P43432 (M23-S335) ≥95%
HY-P78152 IL-23 alpha Protein, Mouse (Biotinylated, HEK293, His-Avi) Q9EQ14 (V22-A196) ≥95%
HY-P74814 IL-23 alpha (175a.a) & IL-12 beta (313a.a) Heterodimer Protein, Mouse (HEK293, His) Q9EQ14 (V22-A196)&P43432 (M23-S335) ≥95%
HY-P700191AF Animal-Free IL-12 beta Protein, Mouse (His) P43432 (M23-S335) ≥95%

相关产品

Pre-clinical Phase
生物活性分子 (3)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-RS06680 IL12B Human Pre-designed siRNA Set A Pre-designed Sets / 否
HY-RS06681 Il12b Mouse Pre-designed siRNA Set A Pre-designed Sets / 否
HY-RS06682 Il12b Rat Pre-designed siRNA Set A Pre-designed Sets / 否

直系同源

种属 基因名 来源 基因 ID
Homo sapiens Il12b NCBI NCBI:3593
Rattus norvegicus Il12b NCBI NCBI:64546
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