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  3. CERK - ceramide kinase Gene

CERK - ceramide kinase Gene

  • 基因
  • 蛋白
  • 疾病
  • 相关产品
  • 直系同源

中文名称：神经酰胺激酶

种属: Homo sapiens

同用名: LK4; hCERK; dA59H18.2; dA59H18.3

基因 ID: 64781 | 基因类型: protein coding

关于 CERK

Cytogenetic location: 22q13.31 Genomic coordinates (GRCh38): 22:46,684,410-46,738,252 (from NCBI)

This gene has 4 transcripts (splice variants), 264 orthologues and 4 paralogues. Ubiquitous expression in small intestine (RPKM 16.4), duodenum (RPKM 15.6) and 25 other tissues.

功能概要

CERK 将神经酰胺转化为神经酰胺 1-磷酸 (C1P) ，这是一种鞘脂代谢物。 CERK 和 C1P 都涉及各种细胞过程，包括增殖、细胞凋亡、吞噬作用和炎症 (Kim 等人，2006 年 [PubMed 16488390]) 。[OMIM 提供，2008 年 3 月]

CERK converts ceramide to ceramide 1-phosphate (C1P), a sphingolipid metabolite. Both CERK and C1P have been implicated in various cellular processes, including proliferation, Apoptosis, phagocytosis, and inflammation (Kim et al., 2006 [PubMed 16488390]).[supplied by OMIM, Mar 2008]

CERK 基因产物(1)

mRNA Protein Name
NM_022766.6 NP_073603.2 ceramide kinase
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables ceramide kinase activity IDA
IDA: 通过直接分析推断
11956206 GOA
enables magnesium ion binding IDA
IDA: 通过直接分析推断
10947957 GOA
enables protein binding IPI
IPI: 通过物理相互作用推断
25416956 GOA
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in ceramide metabolic process IDA
IDA: 通过直接分析推断
19501188 GOA
细胞组分 GO 注释 逻辑证据 参考文献 来源
located in membrane IDA
IDA: 通过直接分析推断
11956206 GOA
located in plasma membrane IDA
IDA: 通过直接分析推断
16269826 GOA
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

CERK 蛋白结构

DAGK_cat

DAGK_cat: Diacylglycerol kinase catalytic domain (132 - 275)

  • 0
  • 100
  • 200
  • 300
  • 400
  • 500
  • 537 a.a.
蛋白主名 其他名称

ceramide kinase

acylsphingosine kinase

CERK 蛋白互作信息

分类
蛋白名称 蛋白编号 互作蛋白 互作蛋白种属 互作蛋白编号 实验方法 参考文献
种属内
CERK Q8TCT0 KRTAP9-2 Homo sapiens Q9BYQ4
Validated Y2H
32296183
种属内
CERK Q8TCT0 KRTAP9-2 Homo sapiens Q9BYQ4
Y2H Array
32296183
种属内
CERK Q8TCT0 KRTAP9-2 Homo sapiens Q9BYQ4
Y2H Prey Pooling
32296183
种属内
CERK Q8TCT0 KRT34 Homo sapiens O76011
Y2H Array
32296183
种属内
CERK Q8TCT0 KRT34 Homo sapiens O76011
Y2H Prey Pooling
32296183
种属内
CERK Q8TCT0 KRTAP11-1 Homo sapiens Q8IUC1
Y2H Prey Pooling
32296183
种属内
CERK Q8TCT0 KRTAP11-1 Homo sapiens Q8IUC1
Y2H Array
32296183
种属内
CERK Q8TCT0 KRTAP1-1 Homo sapiens Q07627
Y2H Prey Pooling
32296183
种属内
CERK Q8TCT0 KRTAP1-1 Homo sapiens Q07627
Y2H Array
32296183
种属内
CERK Q8TCT0 KRTAP6-2 Homo sapiens Q3LI66
Y2H Prey Pooling
32296183
种属内
CERK Q8TCT0 KRTAP6-2 Homo sapiens Q3LI66
Y2H Array
32296183
种属内
CERK Q8TCT0 KRTAP19-6 Homo sapiens Q3LI70
Y2H Prey Pooling
32296183
种属内
CERK Q8TCT0 KRTAP19-6 Homo sapiens Q3LI70
Y2H Array
32296183
种属内
CERK Q8TCT0 KRTAP19-1 Homo sapiens Q8IUB9
Y2H Prey Pooling
32296183
种属内
CERK Q8TCT0 KRTAP19-1 Homo sapiens Q8IUB9
Y2H Array
32296183
种属内
CERK Q8TCT0 NHLRC4 Homo sapiens P0CG21
Y2H Prey Pooling
32296183
种属内
CERK Q8TCT0 NHLRC4 Homo sapiens P0CG21
Y2H Array
32296183
种属内
CERK Q8TCT0 NOTCH2NLC Homo sapiens P0DPK4
Y2H Prey Pooling
32296183
种属内
CERK Q8TCT0 NOTCH2NLC Homo sapiens P0DPK4
Y2H Array
32296183
种属内
CERK Q8TCT0 CYSRT1 Homo sapiens A8MQ03
Y2H Prey Pooling
32296183
种属内
CERK Q8TCT0 CYSRT1 Homo sapiens A8MQ03
Y2H Array
32296183
种属内
CERK Q8TCT0 TRIM42 Homo sapiens Q8IWZ5
Y2H Prey Pooling
32296183
种属内
CERK Q8TCT0 TRIM42 Homo sapiens Q8IWZ5
Y2H Array
32296183
种属内
CERK Q8TCT0 OIP5 Homo sapiens O43482
Y2H Prey Pooling
32296183
种属内
CERK Q8TCT0 OIP5 Homo sapiens O43482
Y2H Array
32296183
种属内
CERK Q8TCT0 CRYBA1 Homo sapiens P05813
Y2H Prey Pooling
32296183
种属内
CERK Q8TCT0 CRYBA1 Homo sapiens P05813
Y2H Array
32296183
种属内
CERK Q8TCT0 PLEKHF2 Homo sapiens Q9H8W4
Y2H Array
32296183
种属内
CERK Q8TCT0 PLEKHF2 Homo sapiens Q9H8W4
Y2H Prey Pooling
32296183
种属内
CERK Q8TCT0 PLEKHF2 Homo sapiens Q9H8W4
Validated Y2H
32296183
种属内
CERK Q8TCT0 MTUS2 Homo sapiens Q5JR59
Y2H Array
25416956
种属内
CERK Q8TCT0 KRTAP3-2 Homo sapiens Q9BYR7
Y2H Prey Pooling
32296183
种属内
CERK Q8TCT0 KRTAP3-2 Homo sapiens Q9BYR7
Y2H Array
32296183
种属内
CERK Q8TCT0 KRTAP3-1 Homo sapiens Q9BYR8
Y2H Array
32296183
种属内
CERK Q8TCT0 KRTAP3-1 Homo sapiens Q9BYR8
Validated Y2H
32296183
种属内
CERK Q8TCT0 KRTAP3-1 Homo sapiens Q9BYR8
Y2H Prey Pooling
32296183
种属间: 跨种属相互作用 种属内: 同种属相互作用

关联疾病

疾病名称 别名
Retinitis Pigmentosa 26

RP26

Retinitis Pigmentosa-26

Retinitis Pigmentosa, Type 26
Cochlear Disease

Cochlear Diseases
Retinitis Pigmentosa

RP

Rod-Cone Dystrophy

Autosomal Recessive Retinitis Pigmentosa

Non-Syndromic Retinitis Pigmentosa

Pericentral Pigmentary Retinopathy

Pigmentary Retinopathy

Tapetoretinal Degeneration

Rcd

Retinitis Pigmentosa Autosomal Recessive

ARRP

Retinitis Pigmentosa, Autosomal Recessive

Retinitis Pigmentosa 1
Farber Lipogranulomatosis

Farber Disease

Acid Ceramidase Deficiency

Ceramidase Deficiency

Ac Deficiency

N-Laurylsphingosine Deacylase Deficiency

Farber'S Disease

FRBRL

Farber'S Lipogranulomatosis

Acylsphingosine Deacylase Deficiency

Farber-Uzman Syndrome

Acy
Hereditary Sensory And Autonomic Neuropathy Type 1

Hereditary Sensory And Autonomic Neuropathy Type I

Hereditary Sensory Neuropathy-Deafness-Dementia Syndrome

Hsan1e

Hsan1

Dnmt1-Related Dementia, Deafness, And Sensory Neuropathy

Hsn1e

Hsnie

Hereditary Sensory Neuropathy Type Ie

Hereditary Sensory Neuropathy-Sensorineural Hearing Loss-Dementia Syndrome

Hereditary Sensory And Autonomic Neuropathy Type Ie

Hereditary Sensory And Autonomic Neuropathy Type 1e

Hereditary Sensory Neuropathy With Hearing Loss And Dementia

Dnmt1-Complex Disorder

Hereditary Sensory And Autonomic Neuropathy Type 1 With Dementia And Hearing Loss

Hsn Ie

Hereditary Sensory Autonomic Neuropathy, Type 1

Hsan1- [Hereditary Sensory And Autonomic Neuropathy Type I]
Retinal Degeneration

Degeneration Of Retina
Intracranial Berry Aneurysm

Familial Aneurysmal Subarachnoid Hemorrhage

Familial Berry Aneurysm

Familial Intracranial Saccular Aneurysm

Saccular Cerebral Aneurysm

Aneurysm, Intracranial Berry

Aneurysmal Subarachnoid Hemorrhage

Aneurysm, Intracranial Berry, 1
Breast Cancer

Breast Carcinoma

Male Breast Cancer

Breast Cancer, Familial

Malignant Neoplasm Of Breast

Breast Cancer, Susceptibility To

Breast Cancer, Early-Onset

Malignant Tumor Of Breast

Carcinoma Of Male Breast

Breast Cancer, Invasive Ductal

Breast Cancer, Protection Against

Breast Cancer, Somatic

Breast Cancer, Male

Breast Cancer, Lobular, Somatic

Breast Tumor

Mammary Cancer

Mammary Tumor

Malignant Neoplasm Of Male Breast

Mammary Carcinoma

Male Breast Carcinoma

Familial Cancer Of Breast

Invasive Ductal Breast Carcinoma

Breast Cancer Susceptibility

Breast Cancer, Male, Susceptibility To

Breast Cancer, Early-Onset, Susceptibility To

Malignant Tumor Of The Breast

Mammary Neoplasm

Primary Breast Cancer

Neoplasm Of Male Breast

Carcinoma Of Breast

Breast Cancer In Men

Familial Breast Cancer

Cancer Of Breast

BC

Breast Cancer Familial

Breast Cancer Familial Male

Breast Cancer, Familial Male

Breast Male Carcinoma

Breast Neoplasms

Breast Neoplasms, Male

Mammary Tumors

Mammary Carcinomas

Cancer, Breast

Cancer, Breast, Susceptibility

Invasive Breast Ductal Carcinoma

Breast Neoplasm

Susceptibility To Breast Cancer

Mammary Neoplasms

Animal Mammary Neoplasms

Primary Malignant Neoplasm Of Breast

Infiltrating Ductal Carcinoma Of Breast

Infiltrating Duct Carcinoma Of Unspecified Site

Infiltrating Ductular Carcinoma Of Unspecified Site

Invasive Breast Carcinoma Of No Special Type

Microinvasive Carcinoma Of Breast

Carcinoma With Apocrine Differentiation
Cone-Rod Dystrophy 2

Cone-Rod Dystrophy

CORD2

Cone-Rod Retinal Dystrophy

Rcrd2

Cone-Rod Retinal Dystrophy 2

Crd2

Cord

Crd

Retinal Cone-Rod Dystrophy

Cone-Rod Retinal Dystrophy-2

Retinal Cone-Rod Dystrophy 2

Tapetoretinal Degeneration

Cone-Rod Degeneration

Cone Rod Dystrophy

Dystrophy, Cone-Rod

Dystrophy, Cone-Rod, Type 2

Retinitis Pigmentosa

Retinitis Pigmentosa 2

Progressive Cone-Rod Dystrophy
疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

相关产品

Pre-clinical Phase
生物活性分子 (2)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-13945 NVP 231 Inducer 99.57% 否
HY-RS02534 CERK Human Pre-designed siRNA Set A Pre-designed Sets / 否

直系同源

种属 基因名 来源 基因 ID
Rattus norvegicus CERK RGD RGD:1305019
Canis familiaris CERK VGNC VGNC:54519
Macaca mulatta CERK VGNC VGNC:71030
Bos taurus CERK VGNC VGNC:55885
Felis catus CERK VGNC VGNC:83527
Mus musculus CERK MGD MGI:2386052
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