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  2. CDK15 - cyclin dependent kinase 15 Gene

CDK15 - cyclin dependent kinase 15 Gene

中文名称:细胞周期蛋白依赖性激酶 15

种属: Homo sapiens

同用名: PFTK2; ALS2CR7; PFTAIRE2

基因 ID: 65061 | 基因类型: protein coding

关于 CDK15

Cytogenetic location: 2q33.1 Genomic coordinates (GRCh38): 2:201,806,429-201,895,550 (from NCBI)

This gene has 10 transcripts (splice variants), 198 orthologues and 26 paralogues. Biased expression in ovary (RPKM 1.2), gall bladder (RPKM 0.5) and 13 other tissues.

功能概要

启用蛋白质丝氨酸/苏氨酸激酶活性。预测参与有丝分裂细胞周期 G1/S 转换中涉及的蛋白质磷酸化和转录调节。预计在胞质溶胶和细胞核中有活性。 [由基因组资源联盟提供,2022 年 4 月]

Enables protein serine/threonine kinase activity. Predicted to be involved in protein phosphorylation and regulation of transcription involved in G1/S transition of mitotic cell cycle. Predicted to be active in cytosol and nucleus. [provided by Alliance of Genome Resources, Apr 2022]

CDK15 基因产物(4)

mRNA Protein Name
NM_001261435.1 NP_001248364.1 cyclin-dependent kinase 15 isoform 1
NM_001261436.1 NP_001248365.1 cyclin-dependent kinase 15 isoform 2
NM_001366386.2 NP_001353315.1 cyclin-dependent kinase 15 isoform 4
NM_139158.2 NP_631897.1 cyclin-dependent kinase 15 isoform 3
基因本体论
  • 分子功能
分子功能 GO 注释 逻辑证据 参考文献 来源
enables protein binding IPI
IPI: 通过物理相互作用推断
22939624 GOA
enables protein serine/threonine kinase activity IDA
IDA: 通过直接分析推断
24866247 GOA
EXP:通过实验结果推断 IDA:通过直接分析推断 IPI:通过物理相互作用推断 IMP:通过突变表型推断 IGI:通过遗传相互作用推断 IEP:通过表达模式推断

CDK15 蛋白结构

Pkinase

Pkinase: Protein kinase domain (105 - 387)

  • 0
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  • 429 a.a.
蛋白主名 其他名称

cyclin-dependent kinase 15

PFTAIRE protein kinase 2

CDK15 蛋白互作信息

分类
蛋白名称 蛋白编号 互作蛋白 互作蛋白种属 互作蛋白编号 实验方法 参考文献
种属内
CDK15 Q96Q40 HSP90AA1 Homo sapiens P07900
Anti Tag CoIP
33961781
种属内
CDK15 Q96Q40 FKBP5 Homo sapiens Q13451
Lumier
25036637
种属内
CDK15 Q96Q40 FKBP5 Homo sapiens Q13451
Anti Tag CoIP
33961781
种属内
CDK15 Q96Q40 FKBP5 Homo sapiens Q13451
TAP
23602568
种属内
CDK15 Q96Q40 HSP90AB1 Homo sapiens P08238
Anti Tag CoIP
22939624
种属内
CDK15 Q96Q40 HSP90AB1 Homo sapiens P08238
Lumier
22939624
种属间: 跨种属相互作用 种属内: 同种属相互作用

关联疾病

疾病名称 别名
Amyotrophic Lateral Sclerosis 2, Juvenile

ALS2

Als, Juvenile

Alsj

Amyotrophic Lateral Sclerosis Type 2

Amyotrophic Lateral Sclerosis 2

Amyotrophic Lateral Sclerosis Type 2, Juvenile

Amyotrophic Lateral Sclerosis Juvenile

Amyotrophic Lateral Sclerosis Juvenile 2

Sclerosis, Lateral, Amyotrophic, Type Type 2

疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

直系同源

种属 基因名 来源 基因 ID
Rattus norvegicus CDK15 RGD RGD:1306205
Macaca mulatta CDK15 VGNC VGNC:70951
Felis catus CDK15 VGNC VGNC:60696
Bos taurus CDK15 VGNC VGNC:106681
Canis familiaris CDK15 VGNC VGNC:39047
Mus musculus CDK15 MGD MGI:3583944
Others CDK15 NCBI