2. Gene
  3. Vps35 - VPS35 retromer complex component Gene

Vps35 - VPS35 retromer complex component Gene

  • 基因
  • 蛋白
  • 相关产品
  • 直系同源

种属: Mus musculus

同用名: Mem3

基因 ID: 65114 | 基因类型: protein coding

关于 Vps35

功能概要

Enables D1 Dopamine Receptor binding activity. Involved in several processes, including negative regulation of macromolecule metabolic process; neurotransmitter receptor transport, endosome to postsynaptic membrane; and positive regulation of cell communication. Located in several cellular components, including neuronal cell body; perinuclear region of cytoplasm; and postsynaptic density. Part of retromer complex. Is active in glutamatergic synapse and presynapse. Is expressed in several structures, including alimentary system; brain; genitourinary system; hemolymphoid system gland; and liver and biliary system. Used to study Parkinson's disease 17. Human ortholog(s) of this gene implicated in Parkinson's disease and Parkinson's disease 17. Orthologous to human VPS35 (VPS35 retromer complex component). [provided by Alliance of Genome Resources, Apr 2022]

Vps35 基因产物(1)

mRNA Protein Name
NM_022997.5 NP_075373.1 vacuolar protein sorting-associated protein 35
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables D1 dopamine receptor binding IPI
IPI: 通过物理相互作用推断
27460146 MGI
enables protein binding IPI
IPI: 通过物理相互作用推断
15965486 MGI
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in lysosome organization IMP
IMP: 通过突变表型推断
26203154 MGI
involved in modulation of chemical synaptic transmission IDA
IDA: 通过直接分析推断
30155515 MGI
involved in modulation of chemical synaptic transmission IEP
IEP: 通过表达模式推断
30155515 MGI
involved in modulation of chemical synaptic transmission IMP
IMP: 通过突变表型推断
30155515 MGI
involved in negative regulation of gene expression IMP
IMP: 通过突变表型推断
26203154 MGI
involved in negative regulation of lysosomal protein catabolic process IMP
IMP: 通过突变表型推断
26203154 MGI
involved in negative regulation of protein homooligomerization IMP
IMP: 通过突变表型推断
26203154 MGI
involved in negative regulation of protein localization IMP
IMP: 通过突变表型推断
26203154 MGI
involved in neurotransmitter receptor transport, endosome to plasma membrane IMP
IMP: 通过突变表型推断
27460146 MGI
involved in neurotransmitter receptor transport, endosome to postsynaptic membrane IDA
IDA: 通过直接分析推断
28384478 MGI
involved in neurotransmitter receptor transport, endosome to postsynaptic membrane IMP
IMP: 通过突变表型推断
28384478 MGI
involved in positive regulation of Wnt protein secretion IMP
IMP: 通过突变表型推断
18160348 MGI
involved in positive regulation of canonical Wnt signaling pathway IGI
IGI: 通过遗传相互作用推断
17239604 MGI
involved in positive regulation of dopamine biosynthetic process IMP
IMP: 通过突变表型推断
26203154 MGI
involved in positive regulation of gene expression IMP
IMP: 通过突变表型推断
26203154 MGI
involved in positive regulation of locomotion involved in locomotory behavior IMP
IMP: 通过突变表型推断
26203154 MGI
involved in protein destabilization IMP
IMP: 通过突变表型推断
26203154 MGI
involved in protein localization to organelle IMP
IMP: 通过突变表型推断
26203154 MGI
involved in regulation of postsynapse assembly IDA
IDA: 通过直接分析推断
26521016 MGI
involved in regulation of postsynapse assembly IMP
IMP: 通过突变表型推断
26521016 MGI
involved in regulation of synapse maturation IDA
IDA: 通过直接分析推断
26521016 MGI
involved in regulation of synapse maturation IMP
IMP: 通过突变表型推断
26521016 MGI
involved in vesicle-mediated transport in synapse IDA
IDA: 通过直接分析推断
28384478 MGI
involved in vesicle-mediated transport in synapse IMP
IMP: 通过突变表型推断
28384478 MGI
involved in voluntary musculoskeletal movement IMP
IMP: 通过突变表型推断
26203154 MGI
细胞组分 GO 注释 逻辑证据 参考文献 来源
located in cytoplasm IDA
IDA: 通过直接分析推断
17239604 MGI
located in cytoplasm IMP
IMP: 通过突变表型推断
26203154 MGI
is active in dopaminergic synapse IDA
IDA: 通过直接分析推断
30155515 MGI
is active in dopaminergic synapse IEP
IEP: 通过表达模式推断
30155515 MGI
is active in dopaminergic synapse IMP
IMP: 通过突变表型推断
30155515 MGI
located in endosome IDA
IDA: 通过直接分析推断
26965651 MGI
is active in glutamatergic synapse IDA
IDA: 通过直接分析推断
26521016 MGI
is active in glutamatergic synapse IEP
IEP: 通过表达模式推断
26521016 MGI
is active in glutamatergic synapse IMP
IMP: 通过突变表型推断
26521016 MGI
located in neuron projection IMP
IMP: 通过突变表型推断
26203154 MGI
located in neuronal cell body IMP
IMP: 通过突变表型推断
26203154 MGI
located in perinuclear region of cytoplasm IMP
IMP: 通过突变表型推断
26203154 MGI
is active in postsynapse IDA
IDA: 通过直接分析推断
26521016 MGI
is active in postsynapse IEP
IEP: 通过表达模式推断
26521016 MGI
is active in postsynapse IMP
IMP: 通过突变表型推断
26521016 MGI
located in postsynaptic density IDA
IDA: 通过直接分析推断
17114649 MGI
is active in presynapse IDA
IDA: 通过直接分析推断
29445238 MGI
part of retromer complex IDA
IDA: 通过直接分析推断
21040701 MGI
located in synapse IDA
IDA: 通过直接分析推断
29118110 MGI
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断
蛋白主名 其他名称

vacuolar protein sorting-associated protein 35

maternal embryonic message 3

vesicle protein sorting 35

Vps35 蛋白互作信息

分类
蛋白名称 蛋白编号 互作蛋白 互作蛋白种属 互作蛋白编号 实验方法 参考文献
种属内
Vps35 Q9EQH3 Vps26a Mus musculus P40336-1
Pull Down
15965486
种属内
Vps35 Q9EQH3 Vps29 Mus musculus Q9QZ88-1
Pull Down
15965486
种属间
Vps35 Q9EQH3 FKBP15 Homo sapiens Q5T1M5
Anti Tag CoIP
20923837
种属间
Vps35 Q9EQH3 FKBP15 Homo sapiens Q5T1M5
Y2H
20923837
种属内
Vps35 Q9EQH3 Sort1 Mus musculus Q6PHU5
Anti Bait CoIP
18480253
种属内
Vps35 Q9EQH3 Sorl1 Mus musculus O88307
Anti Bait CoIP
18480253
种属内
Vps35 Q9EQH3 Vps29 Mus musculus Q9QZ88
Anti Bait CoIP
21040701
种属间: 跨种属相互作用 种属内: 同种属相互作用

相关产品

Pre-clinical Phase
生物活性分子 (2)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-RS15685 VPS35 Human Pre-designed siRNA Set A Pre-designed Sets / 否
HY-RS15686 VPS35L Human Pre-designed siRNA Set A Pre-designed Sets / 否

直系同源

种属 基因名 来源 基因 ID
Homo sapiens Vps35 NCBI NCBI:55737
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