2. Gene
  3. Sort1 - sortilin 1 Gene

Sort1 - sortilin 1 Gene

  • 基因
  • 蛋白
  • 相关产品
  • 直系同源

种属: Mus musculus

同用名: Ntr3; Ntsr3; 2900053A11Rik

基因 ID: 20661 | 基因类型: protein coding

关于 Sort1

功能概要

Predicted to enable several functions, including nerve growth factor binding activity; nerve growth factor receptor activity; and Neurotensin Receptor activity, non-G protein-coupled. Involved in several processes, including glucose import; myotube differentiation; and response to Insulin. Acts upstream of or within endocytosis; negative regulation of fat cell differentiation; and protein targeting to lysosome. Located in cytoplasmic vesicle membrane; plasma membrane; and trans-Golgi network transport vesicle. Is expressed in several structures, including alimentary system; cardiovascular system; central nervous system; eye; and genitourinary system. Orthologous to human SORT1 (sortilin 1). [provided by Alliance of Genome Resources, Apr 2022]

Sort1 基因产物(2)

mRNA Protein Name
NM_001271599.1 NP_001258528.1 sortilin isoform 1 precursor
NM_019972.3 NP_064356.2 sortilin isoform 2 precursor
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables protein binding IPI
IPI: 通过物理相互作用推断
18480253 MGI
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in D-glucose import IMP
IMP: 通过突变表型推断
15992544 MGI
acts upstream of or within endocytosis IMP
IMP: 通过突变表型推断
24163244 MGI
involved in maintenance of synapse structure IDA
IDA: 通过直接分析推断
29398357 MGI
involved in maintenance of synapse structure IMP
IMP: 通过突变表型推断
29398357 MGI
involved in myotube differentiation IMP
IMP: 通过突变表型推断
18258592 MGI
acts upstream of or within negative regulation of fat cell differentiation IDA
IDA: 通过直接分析推断
24928897 MGI
acts upstream of or within protein targeting to lysosome IMP
IMP: 通过突变表型推断
19732768 MGI
involved in response to insulin IMP
IMP: 通过突变表型推断
15992544 MGI
involved in vesicle organization IMP
IMP: 通过突变表型推断
15992544 MGI
细胞组分 GO 注释 逻辑证据 参考文献 来源
is active in cerebellar climbing fiber to Purkinje cell synapse IDA
IDA: 通过直接分析推断
29398357 MGI
is active in cerebellar climbing fiber to Purkinje cell synapse IMP
IMP: 通过突变表型推断
29398357 MGI
located in cytoplasmic vesicle membrane IDA
IDA: 通过直接分析推断
12490950 MGI
located in plasma membrane IDA
IDA: 通过直接分析推断
15992544 MGI
located in trans-Golgi network transport vesicle IDA
IDA: 通过直接分析推断
15078902 MGI
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断
蛋白主名 其他名称

sortilin

mNTR3

neurotensin receptor 3

Sort1 蛋白互作信息

分类
蛋白名称 蛋白编号 互作蛋白 互作蛋白种属 互作蛋白编号 实验方法 参考文献
种属内
Sort1 Q6PHU5 Nradd Mus musculus Q8CJ26
IF
19407813
种属内
Sort1 Q6PHU5 Kcnk2 Mus musculus P97438
Anti Bait CoIP
20405001
种属内
Sort1 Q6PHU5 Vps35 Mus musculus Q9EQH3
Anti Bait CoIP
21040701
种属间: 跨种属相互作用 种属内: 同种属相互作用

相关产品

Pre-clinical Phase
生物活性分子 (11)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-153686 BVFP Inhibitor 98.12% 否
HY-RS13575 SORT1 Human Pre-designed siRNA Set A Pre-designed Sets / 否
HY-W747072 3-Sulfo-taurocholic Acid Disodium Salt ≥99.0% 否
HY-132975 PrDiAzK Inhibitor / 否
HY-153687 SORT-PGRN interaction inhibitor 2 / 否
HY-159868 SORT1-IN-1 Inhibitor / 否
HY-159875 SORT1-IN-2 Inhibitor / 否
HY-159876 SORT1-IN-3 Inhibitor / 否
HY-159877 SORT1-IN-4 Inhibitor / 否
HY-159878 SORT1-IN-5 Inhibitor / 否
HY-D1581 BODIPY 505/515-8-C3-COOH / 否

直系同源

种属 基因名 来源 基因 ID
Homo sapiens Sort1 NCBI NCBI:6272
嗨！很高兴为您提供帮助！

尊敬的 MCE 客户您好，
请您选择所在区域，我们将转接对应客服为您服务！

热门区域

A

B

C

F

G

H

J

L

N

Q

S

T

X

Y

Z

热 A B C F G H J L N Q S T X Y Z