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  3. Pycard - PYD and CARD domain containing Gene

Pycard - PYD and CARD domain containing Gene

  • 基因
  • 蛋白
  • 相关产品
  • 直系同源

种属: Mus musculus

同用名: Asc; TNS1; masc; CARD5; TMS-1; 9130417A21Rik

基因 ID: 66824 | 基因类型: protein coding

关于 Pycard

功能概要

Enables identical protein binding activity and protein dimerization activity. Involved in several processes, including activation of cysteine-type endopeptidase activity; positive regulation of cytokine production; and regulation of defense response. Acts upstream of or within several processes, including defense response to Gram-positive bacterium; positive regulation of macromolecule metabolic process; and regulation of Autophagy. Located in cytosol; extracellular region; and nucleus. Part of inflammasome complex. Is expressed in several structures, including alimentary system; brain; heart; hemolymphoid system gland; and urinary system. Orthologous to human PYCARD (PYD and CARD domain containing). [provided by Alliance of Genome Resources, Apr 2022]

Pycard 基因产物(2)

mRNA Protein Name
NM_023258.4 NP_075747.3 apoptosis-associated speck-like protein containing a CARD
NM_023258.4 NP_075747.3 apoptosis-associated speck-like protein containing a CARD
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables identical protein binding IPI
IPI: 通过物理相互作用推断
24407287 MGI
enables protein binding IPI
IPI: 通过物理相互作用推断
15190255 MGI
enables protein dimerization activity IMP
IMP: 通过突变表型推断
24407287 MGI
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in activation of cysteine-type endopeptidase activity IMP
IMP: 通过突变表型推断
23302887 MGI
acts upstream of or within activation of cysteine-type endopeptidase activity involved in apoptotic process IMP
IMP: 通过突变表型推断
17008311 MGI
involved in activation of innate immune response IMP
IMP: 通过突变表型推断
19158675 MGI
acts upstream of or within defense response to Gram-positive bacterium IMP
IMP: 通过突变表型推断
30248149 MGI
acts upstream of or within inflammatory response IMP
IMP: 通过突变表型推断
15190255 MGI
acts upstream of interleukin-1 beta production IGI
IGI: 通过遗传相互作用推断
22002608 MGI
acts upstream of or within interleukin-1 beta production IGI
IGI: 通过遗传相互作用推断
19158679 MGI
acts upstream of macrophage cytokine production IGI
IGI: 通过遗传相互作用推断
22002608 MGI
involved in macropinocytosis IMP
IMP: 通过突变表型推断
21892172 MGI
involved in myeloid dendritic cell activation involved in immune response IMP
IMP: 通过突变表型推断
21892172 MGI
involved in positive regulation of ERK1 and ERK2 cascade IMP
IMP: 通过突变表型推断
21487011 MGI
involved in positive regulation of T cell migration IMP
IMP: 通过突变表型推断
21892172 MGI
involved in positive regulation of actin filament polymerization IMP
IMP: 通过突变表型推断
21892172 MGI
involved in positive regulation of activated T cell proliferation IMP
IMP: 通过突变表型推断
21892172 MGI
involved in positive regulation of antigen processing and presentation of peptide antigen via MHC class II IMP
IMP: 通过突变表型推断
21892172 MGI
involved in positive regulation of chemokine production IMP
IMP: 通过突变表型推断
21487011 MGI
involved in positive regulation of defense response to virus by host IMP
IMP: 通过突变表型推断
19158675 MGI
involved in positive regulation of inflammatory response IDA
IDA: 通过直接分析推断
27270401 MGI
involved in positive regulation of interleukin-1 beta production IDA
IDA: 通过直接分析推断
27270401 MGI
acts upstream of or within positive regulation of interleukin-1 beta production IGI
IGI: 通过遗传相互作用推断
22002608 MGI
acts upstream of or within positive regulation of interleukin-1 beta production IMP
IMP: 通过突变表型推断
23997220 MGI
involved in positive regulation of interleukin-1 beta production IMP
IMP: 通过突变表型推断
19158675 MGI
involved in positive regulation of interleukin-6 production IMP
IMP: 通过突变表型推断
21892172 MGI
acts upstream of or within positive regulation of macrophage cytokine production IGI
IGI: 通过遗传相互作用推断
22002608 MGI
involved in positive regulation of phagocytosis IMP
IMP: 通过突变表型推断
21892172 MGI
involved in positive regulation of type II interferon production IMP
IMP: 通过突变表型推断
21892172 MGI
involved in regulation of GTPase activity IMP
IMP: 通过突变表型推断
21892172 MGI
acts upstream of or within regulation of apoptotic process IMP
IMP: 通过突变表型推断
15190255 MGI
acts upstream of or within regulation of autophagy IMP
IMP: 通过突变表型推断
24581500 MGI
acts upstream of or within regulation of cysteine-type endopeptidase activity involved in apoptotic process IMP
IMP: 通过突变表型推断
15190255 MGI
acts upstream of or within regulation of inflammatory response IMP
IMP: 通过突变表型推断
22002608 MGI
involved in regulation of protein stability IMP
IMP: 通过突变表型推断
21892172 MGI
acts upstream of or within response to bacterium IMP
IMP: 通过突变表型推断
24581500 MGI
细胞组分 GO 注释 逻辑证据 参考文献 来源
part of NLRP6 inflammasome complex IDA
IDA: 通过直接分析推断
34678144 MGI
part of canonical inflammasome complex IDA
IDA: 通过直接分析推断
30248149 MGI
located in cytosol IDA
IDA: 通过直接分析推断
11139337 MGI
located in extracellular region IDA
IDA: 通过直接分析推断
15190255 MGI
located in nucleus IDA
IDA: 通过直接分析推断
21892172 MGI
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断
蛋白主名 其他名称

apoptosis-associated speck-like protein containing a CARD

PYD and CARD domain-containing protein

Pycard 蛋白互作信息

分类
蛋白名称 蛋白编号 互作蛋白 互作蛋白种属 互作蛋白编号 实验方法 参考文献
种属内
Pycard Q9EPB4 Casp1 Mus musculus P29452
Anti Bait CoIP
34589402
种属内
Pycard Q9EPB4 Casp1 Mus musculus P29452
GMS
22801494
种属内
Pycard Q9EPB4 Casp1 Mus musculus P29452
Cosedimentation
27993998
种属内
Pycard Q9EPB4 Nlrp3 Mus musculus Q8R4B8
IF
27993998
种属内
Pycard Q9EPB4 Nlrp3 Mus musculus Q8R4B8
Anti Bait CoIP
23143333
种属内
Pycard Q9EPB4 Nlrp3 Mus musculus Q8R4B8
Anti Bait CoIP
25605870
种属内
Pycard Q9EPB4 Nlrp3 Mus musculus Q8R4B8
Anti Bait CoIP
34589402
种属内
Pycard Q9EPB4 Nlrp3 Mus musculus Q8R4B8
Cosedimentation
27993998
种属内
Pycard Q9EPB4 Nlrp3 Mus musculus Q8R4B8
GMS
22801494
种属间: 跨种属相互作用 种属内: 同种属相互作用

相关产品

Pre-clinical Phase
生物活性分子 (1)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-RS11485 PYCARD Human Pre-designed siRNA Set A Pre-designed Sets / 否

直系同源

种属 基因名 来源 基因 ID
Homo sapiens Pycard NCBI NCBI:29108
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