2. Gene
  3. Casp1 - caspase 1 Gene

Casp1 - caspase 1 Gene

  • 基因
  • 蛋白
  • 相关产品
  • 直系同源

中文名称：半胱天冬酶 1

种属: Mus musculus

同用名: ICE; Il1bc

基因 ID: 12362 | 基因类型: protein coding

关于 Casp1

Chromosome 9: 5,298,508-5,307,290 forward strand.GRCm39:CM001002.3

This gene has 5 transcripts (splice variants), 456 orthologues, 11 paralogues and is associated with 2 phenotypes. Biased expression in large intestine adult (RPKM 7.4), bladder adult (RPKM 2.2) and 13 other tissues.

功能概要

该基因编码的蛋白可启动半胱氨酸型内肽酶活性。参与多个过程，包括 I-kappaB 激酶/NF-kappaB 信号的正调控；白细胞介素 1 β 生成的正向调节；和蛋白质自动加工。作用于多个过程的上游或内部，包括膜超极化；线粒体去极化；和 IL-1 α 产生的正向调节。位于胞外区。 IPAF 炎性复合体的一部分。表达于膝关节和后肾。与人类 CASP1（caspase 1）同源。 [由基因组资源联盟提供，2022 年 4 月]

Enables cysteine-type endopeptidase activity. Involved in several processes, including positive regulation of I-kappaB kinase/NF-kappaB signaling; positive regulation of interleukin-1 beta production; and protein autoprocessing. Acts upstream of or within several processes, including membrane hyperpolarization; mitochondrial depolarization; and positive regulation of interleukin-1 alpha production. Located in extracellular region. Part of IPAF inflammasome complex. Is expressed in knee joint and metanephros. Orthologous to human CASP1 (Caspase 1). [provided by Alliance of Genome Resources, Apr 2022]

Casp1 基因产物(1)

mRNA Protein Name
NM_009807.2 NP_033937.2 caspase-1
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables cysteine-type endopeptidase activity IDA
IDA: 通过直接分析推断
18667412 MGI
enables peptidase activity IDA
IDA: 通过直接分析推断
18490713 MGI
enables protein binding IPI
IPI: 通过物理相互作用推断
8670890 MGI
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in AIM2 inflammasome complex assembly IDA
IDA: 通过直接分析推断
23567559 MGI
involved in defense response to Gram-negative bacterium IMP
IMP: 通过突变表型推断
29887864 MGI
involved in defense response to bacterium IDA
IDA: 通过直接分析推断
35705808 MGI
acts upstream of interleukin-1 alpha production IMP
IMP: 通过突变表型推断
18490713 MGI
acts upstream of or within interleukin-1 beta production IGI
IGI: 通过遗传相互作用推断
19158679 MGI
acts upstream of interleukin-1 beta production IMP
IMP: 通过突变表型推断
18490713 MGI
acts upstream of macrophage cytokine production IMP
IMP: 通过突变表型推断
18490713 MGI
acts upstream of or within membrane hyperpolarization IMP
IMP: 通过突变表型推断
23028046 MGI
acts upstream of or within mitochondrial depolarization IMP
IMP: 通过突变表型推断
23028046 MGI
involved in positive regulation of canonical NF-kappaB signal transduction IDA
IDA: 通过直接分析推断
16585594 MGI
involved in positive regulation of cytokine production IDA
IDA: 通过直接分析推断
21147462 MGI
involved in positive regulation of inflammatory response IDA
IDA: 通过直接分析推断
27270401 MGI
acts upstream of or within positive regulation of interleukin-1 alpha production IMP
IMP: 通过突变表型推断
18490713 MGI
involved in positive regulation of interleukin-1 beta production IDA
IDA: 通过直接分析推断
21147462 MGI
acts upstream of or within positive regulation of interleukin-1 beta production IMP
IMP: 通过突变表型推断
18490713 MGI
acts upstream of or within positive regulation of macrophage cytokine production IMP
IMP: 通过突变表型推断
18490713 MGI
acts upstream of or within programmed necrotic cell death IDA
IDA: 通过直接分析推断
16429160 MGI
involved in protein autoprocessing IDA
IDA: 通过直接分析推断
21147462 MGI
involved in protein maturation IDA
IDA: 通过直接分析推断
32109412 MGI
acts upstream of or within protein processing IDA
IDA: 通过直接分析推断
11016935 MGI
acts upstream of or within protein processing IMP
IMP: 通过突变表型推断
14663141 MGI
involved in pyroptotic inflammatory response IDA
IDA: 通过直接分析推断
21147462 MGI
acts upstream of or within pyroptotic inflammatory response IMP
IMP: 通过突变表型推断
22002608 MGI
acts upstream of or within regulation of autophagy IMP
IMP: 通过突变表型推断
24581500 MGI
acts upstream of or within regulation of inflammatory response IMP
IMP: 通过突变表型推断
22297845 MGI
acts upstream of or within response to ATP IMP
IMP: 通过突变表型推断
18490713 MGI
acts upstream of or within response to bacterium IMP
IMP: 通过突变表型推断
24581500 MGI
acts upstream of or within response to hypoxia IMP
IMP: 通过突变表型推断
14663141 MGI
acts upstream of or within response to lipopolysaccharide IDA
IDA: 通过直接分析推断
16301672 MGI
细胞组分 GO 注释 逻辑证据 参考文献 来源
part of IPAF inflammasome complex IDA
IDA: 通过直接分析推断
21874021 MGI
is active in cytoplasm IDA
IDA: 通过直接分析推断
21147462 MGI
is active in cytosol IDA
IDA: 通过直接分析推断
35705808 MGI
located in extracellular region IDA
IDA: 通过直接分析推断
15190255 MGI
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

Casp1 蛋白结构

CARD_CASP1-like

CARD_CASP1-like: cd08325 (5 - 86)

CASc

CASc: smart00115 (151 - 399)

  • 0
  • 100
  • 200
  • 300
  • 402 a.a.
蛋白主名 其他名称

caspase-1

CASP-1

IL-1 beta-converting enzyme

IL-1B converting enzyme

IL-1BC

interleukin-1 beta convertase

interleukin-1 beta-converting enzyme

p45

Casp1 蛋白互作信息

分类
蛋白名称 蛋白编号 互作蛋白 互作蛋白种属 互作蛋白编号 实验方法 参考文献
种属间
Casp1 P29452 sctE1 Salmonella typhi Q56134
Pull Down
10051653
种属间
Casp1 P29452 sctE1 Salmonella typhi Q56134
CoIP
10051653
种属内
Casp1 P29452 Pycard Mus musculus Q9EPB4
Crosslink
27993998
种属内
Casp1 P29452 Pycard Mus musculus Q9EPB4
Anti Bait CoIP
25605870
种属内
Casp1 P29452 Pycard Mus musculus Q9EPB4
Anti Bait CoIP
27993998
种属内
Casp1 P29452 Nlrp3 Mus musculus Q8R4B8
Crosslink
27993998
种属间: 跨种属相互作用 种属内: 同种属相互作用

Casp1 抗体

目录号 产品名 应用 反应物种
HY-P81232 Caspase-1 Antibody WB, ELISA, IHC-P, IHC-F, FC, ICC/IF Human, Mouse, Rat,

相关产品

Clinical Phase
生物活性分子 (1)
目录号 产品名 作用方式
纯度 Phase
HY-N0842 Bevirimat Inhibitor 99.80% Phase 2
Pre-clinical Phase
生物活性分子 (6)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-171006 IRF1-IN-1 Inhibitor 99.72% 否
HY-171007 IRF1-IN-2 99.83% 否
HY-150536 EP39 Inhibitor / 否
HY-RS01941 CASP1 Human Pre-designed siRNA Set A Pre-designed Sets / 否
HY-RS01942 Casp1 Mouse Pre-designed siRNA Set A Pre-designed Sets / 否
HY-RS01943 Casp1 Rat Pre-designed siRNA Set A Pre-designed Sets / 否

直系同源

种属 基因名 来源 基因 ID
Homo sapiens Casp1 NCBI NCBI:834
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