SPINT1 - serine peptidase inhibitor, Kunitz type 1 Gene

中文名称：丝氨酸肽酶抑制因子，Kunitz 1 型

种属: Homo sapiens

同用名: HAI; HAI1; MANSC2

基因 ID: 6692 | 基因类型: protein coding

关于 SPINT1

Cytogenetic location: 15q15.1 Genomic coordinates (GRCh38): 15:40,844,048-40,858,207 (from NCBI)

This gene has 11 transcripts (splice variants), 530 orthologues and 13 paralogues. Broad expression in placenta (RPKM 87.0), duodenum (RPKM 69.0) and 15 other tissues.

功能概要

该基因编码的蛋白质是 Kunitz 丝氨酸蛋白酶抑制剂家族的成员。该蛋白是一种有效的 HGF 激活剂特异性抑制剂，被认为参与了损伤组织中 HGF 蛋白水解激活的调节。可变剪接导致编码不同异构体的多个变体。[RefSeq 提供，2008 年 7 月]

The protein encoded by this gene is a member of the Kunitz family of serine Protease Inhibitors. The protein is a potent inhibitor specific for HGF activator and is thought to be involved in the regulation of the proteolytic activation of HGF in injured tissues. Alternative splicing results in multiple variants encoding different isoforms. [provided by RefSeq, Jul 2008]

SPINT1 基因产物(6)

mRNA	Protein	Name
NM_001032367.2	NP_001027539.1	kunitz-type protease inhibitor 1 isoform 2 precursor
NM_001386873.1	NP_001373802.1	kunitz-type protease inhibitor 1 isoform 1 precursor
NM_001386874.1	NP_001373803.1	kunitz-type protease inhibitor 1 isoform 3 precursor
NM_001386875.1	NP_001373804.1	kunitz-type protease inhibitor 1 isoform 4 precursor
NM_003710.4	NP_003701.1	kunitz-type protease inhibitor 1 isoform 2 precursor
NM_181642.3	NP_857593.1	kunitz-type protease inhibitor 1 isoform 1 precursor

基因本体论

分子功能

分子功能 GO 注释	逻辑证据	参考文献	来源
enables protein binding	IPI IPI: 通过物理相互作用推断	15713485	GOA

EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

SPINT1 蛋白结构

MANEC

Kunitz_BPTI

Ldl_recept_a

Kunitz_BPTI

0
100
200
300
400
500
529 a.a.

蛋白主名

其他名称

kunitz-type protease inhibitor 1

HAI-1

重组 SPINT1 蛋白

目录号	产品名	蛋白编号	纯度
HY-P73091	HAI-1 Protein, Human (His)	O43278-2 (G36-V433)	≥95%

关联疾病

疾病名称

别名

Pulmonary Embolism And Infarction

Colorectal Cancer

Colon Cancer	Colorectal Carcinoma
Colon Carcinoma	Colorectal Cancer, Susceptibility To
Carcinoma Of Colon	CRC
Colorectal Cancer With Chromosomal Instability, Somatic	Colon Cancer, Somatic
Colon Cancer, Susceptibility To	Colonic Neoplasms
Colorectal Neoplasms	Colorectal Cancer, Somatic
Colon Cancer, Advanced, Somatic	Colonic Carcinoma
Colorectal Carcinomas	Colon Cancers
Colorectal Cancers	Cancer, Colorectal, Somatic
Cancer, Colon	Cancer, Colorectal, Susceptibility To
Colorectal Neoplasm	Colonic Neoplasm
Malignant Tumor Of Colon

Ichthyosis, Congenital, Autosomal Recessive 11

Autosomal Recessive Congenital Ichthyosis 11	Ichthyosis With Hypotrichosis, Autosomal Recessive
Arih	Ichthyosis And Follicular Atrophoderma With Hypotrichosis And Hypohidrosis
Autosomal Recessive Ichthyosis With Hypotrichosis	ARCI11
Ifah	Hypotrichosis-Congenital Ichthyosis Syndrome
Ichthyosis-Follicular Atrophoderma-Hypotrichosis Syndrome	Ichthyosis-Follicular Atrophoderma-Hypotrichosis-Hypohidrosis Syndrome
Ichthyosis-Hypotrichosis Syndrome	Ifah Syndrome
Ihs

Gastric Cancer

Stomach Cancer	Gastric Carcinoma
Stomach Carcinoma	Gastric Cancer, Somatic
Gastric Neoplasm	Carcinoma Of Stomach
Stomach Neoplasms	Malignant Neoplasm Of Stomach
Gastric Cancer Risk After H. Pylori Infection	Cancer Of The Stomach
Adult Stomach Cancer	Adult Stomach Carcinoma
GASC	Gastric Cancer Intestinal
Gastric Cancers	Gastric Carcinomas
Cancer, Gastric	Stomach Neoplasm
Malignant Neoplasm Of Body Of Stomach	Malignant Tumor Of Lesser Curve Of Stomach
Gastrocarcinoma Of Unspecified Site	Leather Bottle Stomach
Carcinoma Of Fundus Of Stomach	Cancer Of Fundus Of Stomach
Primary Malignant Neoplasm Of Body Of Stomach	Cancer Of Body Of Stomach
Primary Malignant Neoplasm Of Pyloric Antrum	Pyloric Antrum Cancer
Malignant Tumour Of Stomach

Prostate Cancer

Prostate Carcinoma	Prostate Cancer, Familial
Prostate Neoplasm	Prostate Cancer, Somatic
Prostate Cancer, Susceptibility To	Prostatic Cancer
Prostatic Neoplasms	Hereditary Prostate Cancer
Prostatic Neoplasm	Cancer Of Prostate
Carcinoma Of Prostate	Familial Prostate Cancer
Familial Prostate Carcinoma	Malignant Tumor Of Prostate
Malignant Neoplasm Of Prostate	Prostate Cancer, Familial, Susceptibility To
Malignant Tumor Of The Prostate	Ngp - New Growth Of Prostate
Tumor Of The Prostate	Prostate Cancer, Hereditary
Cancer Of The Prostate	Malignant Neoplasm Of The Prostate
Prostatic Carcinoma	PC
Prca	Cancer, Prostate
Malignant Prostatic Tumour	Malignant Tumour Of Prostate
Primary Prostate Cancer	Primary Malignant Neoplasm Of Prostate
Prostate Gland Cancer

Ovarian Cancer

Ovarian Carcinoma	Ovarian Neoplasm
Malignant Tumour Of Ovary	Cancer Of The Ovary
Epithelial Ovarian Cancer	Neoplasm Of Ovary
Ovarian Neoplasms	Ovarian Cancers
Malignant Neoplasm Of Ovary	Primary Malignant Neoplasm Of Ovary
Ovarian Cancer, Somatic	Malignant Ovarian Tumor
Ovary Neoplasm	Primary Ovarian Cancer
Tumor Of The Ovary	Malignant Neoplasm Of The Ovary
Malignant Tumor Of The Ovary	Ovarian Malignant Tumor
OC	Ovarian Carcinomas
Cancer, Ovarian	Cancer Of Ovary
Ovary Cancer	Ca Ovary

疾病名称	别名
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Cat. No.	产品名	作用方式	纯度	是否罕见病
HY-RS13685	SPINT1 Human Pre-designed siRNA Set A	Pre-designed Sets	/	否

直系同源

种属	基因名	来源	基因 ID
Rattus norvegicus	SPINT1	RGD	RGD:1303138
Felis catus	SPINT1	VGNC	VGNC:65640
Canis familiaris	SPINT1	VGNC	VGNC:46746
Bos taurus	SPINT1	VGNC	VGNC:35221
Mus musculus	SPINT1	MGD	MGI:1338033
Others	SPINT1	NCBI

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MedChemExpress (MCE) 只为有资质的科研机构、医药企业基于科学研究或药证申报的用途提供医药研发服务，不为任何个人或者非科研性质的、非用于药证申报使用等其他用途提供服务。

站点地图隐私声明

沪ICP备15051369号-4

上海工商

沪公网安备31011502019417

沪(浦)应急管危经许[2021]201709(QFYS)

营业执照（三证合一）

SPINT1 - serine peptidase inhibitor, Kunitz type 1 Gene

关于 SPINT1

功能概要

SPINT1 基因产物(6)

SPINT1 蛋白结构

重组 SPINT1 蛋白

关联疾病

直系同源

热门区域

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SPINT1 - serine peptidase inhibitor, Kunitz type 1 Gene

关于 SPINT1

功能概要

SPINT1 基因产物(6)

SPINT1 蛋白结构

重组 SPINT1 蛋白

关联疾病

相关产品

直系同源

热门区域

A

B

C

F

G

H

J

L

N

Q

S

T

X

Y

Z