2. Gene
  3. SRP19 - signal recognition particle 19 Gene

SRP19 - signal recognition particle 19 Gene

  • 基因
  • 蛋白
  • 疾病
  • 相关产品
  • 直系同源

中文名称：信号识别粒子 19

种属: Homo sapiens

基因 ID: 6728 | 基因类型: protein coding

关于 SRP19

Cytogenetic location: 5q22.2 Genomic coordinates (GRCh38): 5:112,861,287-112,898,371 (from NCBI)

This gene has 12 transcripts (splice variants) and 210 orthologues. Ubiquitous expression in thyroid (RPKM 11.2), bone marrow (RPKM 8.6) and 25 other tissues.

功能概要

启用 7S RNA 结合活性。有助于核糖体结合活性。预计参与 SRP 依赖性共翻译蛋白靶向膜、信号序列识别。位于核仁。部分信号识别颗粒，内质网靶向。 [由基因组资源联盟提供，2022 年 4 月]

Enables 7S RNA binding activity. Contributes to ribosome binding activity. Predicted to be involved in SRP-dependent cotranslational protein targeting to membrane, signal sequence recognition. Located in nucleolus. Part of signal recognition particle, endoplasmic reticulum targeting. [provided by Alliance of Genome Resources, Apr 2022]

SRP19 基因产物(5)

mRNA Protein Name
NM_001204193.2 NP_001191122.1 signal recognition particle 19 kDa protein isoform 2
NM_001204194.2 NP_001191123.1 signal recognition particle 19 kDa protein isoform 3
NM_001204196.2 NP_001191125.1 signal recognition particle 19 kDa protein isoform 4
NM_001204199.2 NP_001191128.1 signal recognition particle 19 kDa protein isoform 6
NM_003135.3 NP_003126.1 signal recognition particle 19 kDa protein isoform 1
基因本体论
  • 分子功能
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables 7S RNA binding IDA
IDA: 通过直接分析推断
17434535 GOA
enables RNA binding IPI
IPI: 通过物理相互作用推断
17434535 GOA
enables protein binding IPI
IPI: 通过物理相互作用推断
24700861 GOA
contributes to ribosome binding IDA
IDA: 通过直接分析推断
27899666 GOA
细胞组分 GO 注释 逻辑证据 参考文献 来源
located in nucleolus IDA
IDA: 通过直接分析推断
10618370 GOA
part of signal recognition particle IDA
IDA: 通过直接分析推断
27899666 GOA
part of signal recognition particle, endoplasmic reticulum targeting IDA
IDA: 通过直接分析推断
18089836 GOA
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

SRP19 蛋白结构

SRP19

SRP19: SRP19 protein (16 - 116)

  • 0
  • 100
  • 144 a.a.
蛋白主名 其他名称

signal recognition particle 19 kDa protein

signal recognition particle 19kD

SRP19 蛋白互作信息

分类
蛋白名称 蛋白编号 互作蛋白 互作蛋白种属 互作蛋白编号 实验方法 参考文献
种属内
SRP19 P09132 SRP68 Homo sapiens Q9UHB9
Anti Tag CoIP
35271311
种属内
SRP19 P09132 SRP68 Homo sapiens Q9UHB9
X-Ray Diffraction
24700861
种属内
SRP19 P09132 SRP68 Homo sapiens Q9UHB9
GMS
24700861
种属间: 跨种属相互作用 种属内: 同种属相互作用

关联疾病

疾病名称 别名
Severe Congenital Neutropenia

Congenital Neutropenia

Neutropenia, Severe Congenital

Congenital Agranulocytosis

Infantile Genetic Agranulocytosis

Kostmann Disease

Kostmann'S Agranulocytosis

Kostmann'S Syndrome

Severe Infantile Genetic Neutropenia
Shwachman-Diamond Syndrome 1

Shwachman-Diamond Syndrome

Shwachman Syndrome

Shwachman-Bodian-Diamond Syndrome

Sds

Pancreatic Insufficiency And Bone Marrow Dysfunction

Shwachman-Bodian Syndrome

SDS1

Lipomatosis Of Pancreas, Congenital

Congenital Lipomatosis Of Pancreas

Shwachman-Diamond Type Metaphyseal Dysplasia

Metaphyseal Chondrodysplasia, Shwachman Type

Shwachman-Diamond-Oski Syndrome
Dental Fluorosis

Mottled Teeth

Intrinsic Enamel Discolouration Of Fluorosis

Mottling Of Enamel

Fluorosis, Dental

Dental Fluorosis, Acquired
Immunodeficiency 51

IMD51

Candf5

Candidiasis, Familial, 5

Candidiasis, Familial, 5, Formerly

Candf5, Formerly

Familial Candidiasis 5

Candidiasis Familial 5 Autosomal Recessive

Candidiasis Familial Chronic Mucocutaneous Autosomal Recessive

Chronic Mucocutaneous Candidiasis 5
疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

相关产品

Pre-clinical Phase
生物活性分子 (1)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-RS13772 SRP19 Human Pre-designed siRNA Set A Pre-designed Sets / 否

直系同源

种属 基因名 来源 基因 ID
Canis familiaris SRP19 VGNC VGNC:56002
Rattus norvegicus SRP19 RGD RGD:1308437
Felis catus SRP19 VGNC VGNC:97644
Mus musculus SRP19 MGD MGI:1913634
Bos taurus SRP19 VGNC VGNC:55145
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