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  2. SSTR2 - somatostatin receptor 2 Gene

SSTR2 - somatostatin receptor 2 Gene

中文名称:生长抑素受体 2

种属: Homo sapiens

同用名: SST2

基因 ID: 6752 | 基因类型: protein coding

关于 SSTR2

Cytogenetic location: 17q25.1 Genomic coordinates (GRCh38): 17:73,165,010-73,176,633 (from NCBI)

This gene has 2 transcripts (splice variants), 264 orthologues and 17 paralogues. Biased expression in brain (RPKM 12.7), adrenal (RPKM 3.5) and 10 other tissues.

功能概要

生长抑素作用于许多位点以抑制许多激素和其他分泌蛋白的释放。生长抑素的生物学作用可能是由以组织特异性方式表达的 G 蛋白偶联受体家族介导的。 SSTR2 是具有七个跨膜区段的受体超家族的成员,在大脑和肾脏中的表达水平最高。[RefSeq 提供,2008 年 7 月]

Somatostatin acts at many sites to inhibit the release of many Hormones and Other secretory proteins. The biologic effects of somatostatin are probably mediated by a family of G protein-coupled receptors that are expressed in a tissue-specific manner. SSTR2 is a member of the superfamily of receptors having seven transmembrane segments and is expressed in highest levels in cerebrum and kidney. [provided by RefSeq, Jul 2008]

SSTR2 基因产物(1)

mRNA Protein Name
NM_001050.3 NP_001041.1 somatostatin receptor type 2

SSTR2 蛋白结构

7tm_1

7tm_1: 7 transmembrane receptor (rhodopsin family) (60 - 312)

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  • 369 a.a.
蛋白主名 其他名称

somatostatin receptor type 2

SRIF-1

SS2R

SSTR2 蛋白互作信息

分类
蛋白名称 蛋白编号 互作蛋白 互作蛋白种属 互作蛋白编号 实验方法 参考文献
种属内
SSTR2 P30874 SSTR3 Homo sapiens P32745
Anti Tag CoIP
22651821
种属内
SSTR2 P30874 SSTR3 Homo sapiens P32745
FRET
22651821
种属内
SSTR2 P30874 PIK3R1 Homo sapiens P27986
Pull Down
16917505
种属间: 跨种属相互作用 种属内: 同种属相互作用

重组 SSTR2 蛋白

目录号 产品名 蛋白编号 纯度
HY-P700430 SSTR2 Protein-VLP, Human (HEK293, His) P30874 (M1-I369) ≥95%

关联疾病

疾病名称 别名
Acth-Secreting Pituitary Adenoma

Acth-Producing Pituitary Adenoma

Corticotroph Adenoma

Corticotropinoma

Pituitary-Dependent Cushing'S Disease

Adrenal Gland Hyperfunction

Cushing Syndrome

Gastrointestinal Neuroendocrine Tumor

Gastrointestinal Neuroendocrine Tumour

Malignant Gastrointestinal Neuroendocrine Tumor

Malignant Gastrointestinal Neuroendocrine Tumour

Digestive System Neuroendocrine Neoplasm

Digestive System Neuroendocrine Tumor

Meningioma, Familial

Meningioma

Familial Meningioma

Meningioma, Familial, Susceptibility To

Meningeal Neoplasm

Meningeal Neoplasms

Meningiomas

Meningioma, Nf2-Related, Somatic

Meningioma, Sis-Related

Meningothelial Cell Tumor

Neoplasm Of The Meninges

Primary Meningeal Tumor

Familial Multiple Meningioma

MNGMA

Meningioma, Benign, No Icd-O Subtype

Intracranial Meningioma

Meningothelial Cell Neoplasm

Supratentorial Meningioma

Primary Neoplasm Of Spinal Meninges

Benign Intracranial Meningioma

Benign Meningioma

Meningeal Tumours

Meningeal Sarcoma Of Unspecified Site

Meningothelial Sarcoma Of Unspecified Site

Pulmonary Neuroendocrine Tumor

Neuroendocrine Neoplasm Of Lung

Skull Base Cancer

Tumors Of Skull Base

Skull Base Neoplasms

Paraganglioma

Chemodectoma

Glomus Body Tumor

Paragangliomas

Carotid Body Paraganglioma

Extra-Adrenal Paraganglioma

Hormone Producing Pituitary Cancer

Growth Hormone Producing Pituitary Tumor

Pituitary Tumors, Hormone Producing

Somatotropinoma

Growth Hormone-Producing Pituitary Gland Neoplasm

Prolactinoma

Prolactin-Producing Pituitary Gland Adenoma

Prolactin-Secreting Pituitary Adenoma

Forbes-Albright Syndrome

Lactotroph Adenoma

Prl-Secreting Pituitary Adenoma

Prloma

Pituitary Lactotrophic Adenoma

Familial Prolactinoma

Pituitary Adenoma, Prolactin-Secreting

Prolactinoma Of Pituitary Gland

PSPA

Pituitary Carcinoma

Pituitary Cancer

Carcinoma Of The Pituitary Gland

Malignant Neoplasm Of Pituitary Gland

Intracranial Meningioma

Meningioma

Endocrine Organ Benign Neoplasm
Solitary Fibrous Tumor/Hemangiopericytoma

Sft/Hpc

Hyperinsulinemic Hypoglycemia

Nesidioblastosis

Islet Cell Hyperplasia

Persistent Hyperinsulinemia Hypoglycemia Of Infancy

Hyperinsulinemic Hypoglycaemia

Microcystic Meningioma
Optic Nerve Neoplasm

Optic Nerve Neoplasms

Neoplasm Of Optic Nerve

Tumor Of Second Cranial Nerve

Tumour Of Optic Nerve

Functioning Pituitary Adenoma

Secretory Adenoma Of The Pituitary Gland

Endocrine Active Pituitary Adenoma

Secreting Pituitary Adenoma

Pituitary Adenoma, Functioning

Pituitary Gland Disease

Pituitary Diseases

Pituitary Dysfunction

Pituitary Disease

Pituitary Deficiency

Pituitary Disorders

Thyroid Gland Medullary Carcinoma

Medullary Thyroid Carcinoma

Medullary Carcinoma Of The Thyroid Gland

Ultimobranchial Thyroid Tumor

Ultimobranchial Thyroid Tumour

Thyroid Cancer, Medullary

Thyroid Gland Cancer

Thyroid Gland Carcinoma

Malignant Neoplasm Of Thyroid Gland

Malignant Tumour Of Thyroid Gland

Thyroid Neoplasm

Thyroid Neoplasms

Neoplasm Of Thyroid Gland

Thyroid Gland Neoplasm

Head And Neck Cancer, Thyroid

Neoplasm Of The Thyroid Gland

Cancer Of The Thyroid

Primary Malignant Neoplasm Of Thyroglossal Duct

Malignant Neoplasm Of Thyroglossal Duct

Primary Malignant Neoplasm Of Thyroid Gland

Thyroglossal Duct Cancer

Toxic Goitre Malignant Tumour

Cancerous Goitre

Hyperpituitarism
Medulloblastoma

MDB

Cpnet

Localized Primitive Neuroectodermal Tumor

Classic Medulloblastoma

Desmoplastic/Nodular Medulloblastoma

Medulloblastoma With Extensive Nodularity

Desmoplastic Medulloblastoma

Medulloblastoma, Somatic

Medulloblastoma, Desmoplastic

Brain Medulloblastoma

Cns Pnet

Infratentorial Primitive Neuroectodermal Tumor

Mben

Medulloblastoma Desmoplastic

Neuroectodermal Tumors, Primitive

Medulloblastomas

Medulloblastoma, With Extensive Nodularity

Medulloblastoma Of Unspecified Site

Medullomyoblastoma Of Unspecified Site

Growth Hormone Secreting Pituitary Adenoma

Somatotroph Adenoma

Growth Hormone-Secreting Pituitary Adenoma

Growth Hormone Producing Adenoma Of The Pituitary

Growth Hormone Secreting Adenoma Of Pituitary

Esophageal Neuroendocrine Tumor

Esophageal Neuroendocrine Tumour

Neuroendocrine Tumor Of Esophagus

Neuroendocrine Tumour Of Oesophagus

Adenoma

Acinar Cell Adenoma

Adenomas

Acinic Cell Adenoma

Skull Base Meningioma

Meningioma Of The Skull Base

Gastrinoma

Gastrin Cell Tumour

Gastrin Secreting Tumor

Malignant Gastrinoma

Gastrinoma, Malignant

Somatostatinoma

Somatostatin Cell Neoplasm

Somatostatin Cell Tumour

Ampullary Somatostatinoma

Carcinoid Somatostatinoma

Malignant Islet Cell Tumor

Somatomedin-Secreting Carcinoid

Somatostatin-Secreting Pancreatic Neoplasm

Pancreatic Somatostatinoma

Pancreatic Endocrine Carcinoma

Pituitary Adenoma

Pituitary Neoplasms

Adenoma Of The Pituitary Gland

Pituitary Adenomas

Adenoma, Pituitary

Pituitary Gland Adenoma

Insulinoma

Islet Cell Adenoma

Insulin-Producing Tumor Of Islet Cells

Adenoma Islet Cell

Islet Cell Tumor

Experimental Organism Islet Cell Adenoma Neoplasm

Pancreatic Cancer

Pancreatic Carcinoma

Familial Pancreatic Carcinoma

Pancreatic Neoplasm

Carcinoma Of Pancreas

Pancreatic Carcinoma, Familial

Malignant Neoplasm Of Pancreas

Pancreatic Acinar Carcinoma

Pancreatic Tumor

Familial Pancreatic Cancer

Neoplasm Of The Pancreas

Pancreatic Carcinoma, Somatic

Pancreatic Cancer, Somatic

Ca Body Of Pancreas

Ca Head Of Pancreas

Ca Tail Of Pancreas

Malignant Neoplasm Of Body Of Pancreas

Malignant Neoplasm Of Head Of Pancreas

Malignant Neoplasm Of Tail Of Pancreas

Pancreas Neoplasm

Exocrine Cancer

Exocrine Pancreas Carcinoma

Hereditary Pancreatic Cancer

Hereditary Pancreatic Carcinoma

PNCA

Cancer Of The Pancreas

Pancreatic Cancer, Susceptibility To

Carcinoma Of Head Of Pancreas

Pancreatic Neoplasms

Pancreatic Tumors

Cancer, Pancreatic

Cancer Of Pancreas

Mixed Islet Cell With Exocrine Carcinoma Of Unspecified Site

Neuroendocrine Tumor

Neuroendocrine Neoplasm

Neuroendocrine Tumors

Carcinoma, Neuroendocrine

Polycystic Liver Disease

Autosomal Dominant Polycystic Liver Disease

Isolated Polycystic Liver Disease

Pcld

Congenital Cystic Liver Disease

Congenital Hepatic Cyst

Fibrocystic Liver Disease

Isolated Autosomal Dominant Polycystic Liver Disease

Adpcld

Liver Disease, Polycystic

Multiple Cysts Of Liver

Pld - [Polycystic Liver Disease]

Polycystic Liver Disorder

Polycystic Liver

Congenital Polycystic Disease Of Liver

Congenital Polycystic Liver Disease

Meningothelial Meningioma

Meningotheliomatous Meningioma

Optic Nerve Sheath Meningioma

Meningioma Of Optic Nerve Sheath

Endocrine Pancreas Disease

Disorder Of Endocrine Pancreas

Multiple Endocrine Neoplasia, Type I

Multiple Endocrine Neoplasia Type 1

MEN1

Wermer Syndrome

Multiple Endocrine Neoplasia 1

Multiple Endocrine Neoplasia, Type 1

Men I

Endocrine Adenomatosis, Multiple

Mea I

Men Type I

Wermer'S Syndrome

Men1 Syndrome

Multiple Endocrine Adenomatosis

Endocrine Adenomatosis Multiple

Men 1

Familial Multiple Endocrine Neoplasia Type I

Neoplasia, Endocrine, Multiple, Type 1

Multiple Endocrine Neoplasia

Sudden Infant Death Syndrome

SIDS

Sudden Infant Death Syndrome, Susceptibility To

Cot Death

Crib Death

Sudden Death Of Nonspecific Cause In Infancy

Sudden Infant Death

Death, Sudden, Syndrome, Infant

Psammomatous Meningioma
Pancreatic Endocrine Carcinoma

Carcinoma Of Endocrine Pancreas

Islet Cell Carcinoma

Malignant Neoplasm Of Islets Of Langerhans

Pancreatic Neuroendocrine Carcinoma

Carcinoma Islet Cell

Carcinoma, Islet Cell

Pancreatic Cystadenoma

Cystadenoma Of Pancreas

Thyroid Carcinoma, Familial Medullary

Medullary Thyroid Carcinoma

Familial Medullary Thyroid Carcinoma

MTC

Fmtc

Mtc1

Thyroid Cancer, Medullary

Medullary Thyroid Cancer

Thyroid Carcinoma, Medullary

Familial Mtc

Thyroid Carcinoma Medullary

Carcinoma, Thyroid, Medullary, Familial

Medullary Carcinoma Of Thyroid

Medullary Carcinoma With Amyloid Stroma, Unspecified Site

Medullary Carcinoma With Amyloid Stroma Of Thyroid

Cranial Nerve Malignant Neoplasm

Cranial Nerve Neoplasms

Malignant Neoplasm Of Cranial Nerve

Malignant Tumor Of Cranial Nerve

Malignant Tumor Of The Cranial Nerve

Islet Cell Tumor

Pancreatic Neuroendocrine Tumor

Neuroendocrine Tumor Of Pancreas

Pnet

Pancreatic Net

Well-Differentiated Nen Of Pancreas

Well-Differentiated Neuroendocrine Neoplasm Of Pancreas

Well-Differentiated Pancreatic Nen

Well-Differentiated Pancreatic Neuroendocrine Neoplasm

Endocrine Pancreas Cancer

Islet Cell Neoplasm

Islet Cell Tumour

Malignant Pancreatic Endocrine Tumor

Malignant Pancreatic Endocrine Tumour

Malignant Tumor Of Endocrine Pancreas

Malignant Tumour Of Endocrine Pancreas

Pancreatic Endocrine Neoplasm

Pancreatic Endocrine Tumor

Pancreatic Neuroendocrine Neoplasm

Adenoma, Islet Cell

Well Differentiated Pancreatic Endocrine Tumor

Malignant Neoplasm Of Endocrine Pancreas

Pancreatic Endocrine Carcinoma

Acromegaly

Gigantism

Growth Hormone Excess

Pituitary Giant

Somatotroph Adenoma

Growth Hormone-Secreting Pituitary Adenoma

Carcinoid Tumors, Intestinal

Gastrointestinal Carcinoid Tumor

Argentaffinoma

Carcinoid

Intestinal Carcinoid Tumor

ICT

Tumor, Carcinoid, Intestinal

Malignant Carcinoid Syndrome

Carcinoid Tumor Of Intestine

Carcinoid Tumor

Carcinoid Tumor No Icd-O Subtype

Brain Meningioma

Intracranial Meningioma

Angiomatous Meningioma
疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

直系同源

种属 基因名 来源 基因 ID
Canis familiaris SSTR2 VGNC VGNC:46844
Bos taurus SSTR2 VGNC VGNC:35326
Rattus norvegicus SSTR2 RGD RGD:3763
Macaca mulatta SSTR2 VGNC VGNC:77893
Felis catus SSTR2 VGNC VGNC:65711
Mus musculus SSTR2 MGD MGI:98328
Others SSTR2 NCBI