STK10 - serine/threonine kinase 10 Gene

中文名称：丝氨酸/苏氨酸激酶 10

种属: Homo sapiens

同用名: LOK; PRO2729

关于 STK10

功能概要

该基因编码丝氨酸/苏氨酸蛋白激酶 Ste20 家族的一个成员，类似于几种已知的 polo 样激酶激酶。该蛋白可以与 polo 样激酶 1 结合并磷酸化，并且该蛋白的激酶死亡版本的过表达会干扰正常的细胞周期进程。该激酶还可以通过有丝分裂原活化蛋白激酶激酶 1 通路负向调节 T 细胞中白细胞介素 2 的表达。[RefSeq 提供，2008 年 7 月]

This gene encodes a member of the Ste20 family of serine/threonine protein kinases, and is similar to several known polo-like kinase kinases. The protein can associate with and phosphorylate polo-like kinase 1, and overexpression of a kinase-dead version of the protein interferes with normal cell cycle progression. The kinase can also negatively regulate interleukin 2 expression in T-cells via the mitogen activated protein kinase kinase 1 pathway. [provided by RefSeq, Jul 2008]