2. Gene
  3. Atr - ATR serine/threonine kinase Gene

Atr - ATR serine/threonine kinase Gene

  • 基因
  • 蛋白
  • 相关产品
  • 直系同源

中文名称：ATR 丝氨酸/苏氨酸激酶

种属: Rattus norvegicus

基因 ID: 685055 | 基因类型: protein coding

关于 Atr

Primary_assembly 8: 96,426,724-96,524,136 forward strand.mRatBN7.2:CM026981.1

This gene has 2 transcripts (splice variants), 209 orthologues, 5 paralogues and is associated with 19 phenotypes. Biased expression in Testes (RPKM 162.8), Thymus (RPKM 69.6) and 9 other tissues.

功能概要

预测该基因编码的蛋白可启动 MutLalpha 复杂绑定活动； MutSalpha 复合体结合活性；和蛋白丝氨酸/苏氨酸激酶活性。参与对含砷物质的反应和对外源性刺激的反应。预测位于高尔基体； PML 主体；和 XY 身体。预计活跃于核心。该基因的人类直系同源物与 Seckel 综合征 1 相关；腺样囊性癌；结肠癌;肺癌；和胰腺癌。与人类 ATR（ATR 丝氨酸/苏氨酸激酶）同源。 [由基因组资源联盟提供，2022 年 4 月]

Predicted to enable MutLalpha complex binding activity; MutSalpha complex binding activity; and protein serine/threonine kinase activity. Involved in response to arsenic-containing substance and response to xenobiotic stimulus. Predicted to be located in Golgi apparatus; PML body; and XY body. Predicted to be active in nucleus. Human ortholog(s) of this gene implicated in Seckel syndrome 1; adenoid cystic carcinoma; colon cancer; lung cancer; and pancreatic Cancer. Orthologous to human ATR (ATR serine/threonine kinase). [provided by Alliance of Genome Resources, Apr 2022]

Atr 基因产物(3)

mRNA Protein Name
XM_006243600.4 XP_006243662.1 serine/threonine-protein kinase ATR isoform X2
XM_039082561.1 XP_038938489.1 serine/threonine-protein kinase ATR isoform X2
XM_003750561.5 XP_003750609.1 serine/threonine-protein kinase ATR isoform X1
基因本体论
  • 生物过程
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in response to arsenic-containing substance IEP
IEP: 通过表达模式推断
29097844 RGD
involved in response to xenobiotic stimulus IEP
IEP: 通过表达模式推断
19263217 RGD
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

Atr 蛋白结构

UME

UME: smart00802 (1119 - 1225)

FAT

FAT: pfam02259 (1765 - 2086)

TEL1

TEL1: cl34875 (2117 - 2635)

PIKKc_ATR

PIKKc_ATR: cd00892 (2284 - 2558)

  • 0
  • 500
  • 1000
  • 1500
  • 2000
  • 2636 a.a.
蛋白主名 其他名称

serine/threonine-protein kinase ATR

ataxia telangiectasia and Rad3 related

ataxia telangiectasia and rad3 related-like

相关产品

Clinical Phase
生物活性分子 (5)
目录号 产品名 作用方式
纯度 Phase
HY-19323 Ceralasertib Inhibitor 99.76% Phase 2
HY-101566 Elimusertib Inhibitor 99.99% Phase 2
HY-139609 Camonsertib Inhibitor 99.75% Phase 2
HY-101566A Elimusertib hydrochloride Inhibitor 99.85% Phase 2
HY-13902 Berzosertib Inhibitor 99.70% Phase 1
Pre-clinical Phase
生物活性分子 (23)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-14731 VE-821 Inhibitor 98.32% 否
HY-15557 AZ20 Inhibitor 99.40% 否
HY-136270 Gartisertib Inhibitor 99.76% 否
HY-15520 CGK733 Inhibitor 99.83% 否
HY-15521 ETP-46464 Inhibitor 99.55% 否
HY-N6954 Garcinone C Activator 99.66% 否
HY-13816 NU6027 Inhibitor 99.04% 否
HY-P10280 ATR kinase substrate peptide Inhibitor 99.17% 否
HY-159480 AD1058 Inhibitor / 否
HY-147190 ATR-IN-19 Inhibitor / 否
HY-147569 ATR-IN-17 Inhibitor / 否
HY-157767 Abd110 Inhibitor / 否
HY-141478 Antitumor agent-28 Inhibitor / 否
HY-147565 ATR-IN-13 Inhibitor / 否
HY-161838 ICT10336 Inhibitor / 否
HY-153729 ATR-IN-29 Inhibitor / 否
HY-153393 ATR-IN-21 Inhibitor / 否
HY-147568 ATR-IN-16 Inhibitor / 否
HY-144214 ATR-IN-10 Inhibitor / 否
HY-147566 ATR-IN-14 Inhibitor / 否
HY-147570 ATR-IN-18 Inhibitor / 否
HY-147567 ATR-IN-15 Inhibitor / 否
HY-151915 ATR-IN-20 Inhibitor / 否

直系同源

种属 基因名 来源 基因 ID
Homo sapiens Atr NCBI NCBI:545
Macaca fascicularis Atr NCBI NCBI:101926636
Mus musculus Atr NCBI NCBI:245000
Macaca mulatta Atr NCBI NCBI:714443
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