2. Cell Cycle/DNA Damage PI3K/Akt/mTOR
  3. ATM/ATR
  4. Antitumor agent-28

Antitumor agent-28 选择性调节共济失调毛细血管扩张突变 (ATM) 激酶。Antitumor agent-28 可预防 ATM 介导的疾病并具有有效的抗癌活性。

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Antitumor agent-28 Chemical Structure

Antitumor agent-28 Chemical Structure

CAS No. : 2097499-67-5

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Antitumor agent-28 相关抗体

Top Publications Citing Use of Products

查看 ATM/ATR 亚型特异性产品:

查看所有亚型
ATM ATR

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Antitumor agent-28 selectively inhibits ataxia telangiectasia mutated (ATM) kinase. Antitumor agent-28 prevents ATM mediated disease and has potent anti-cancer activity[1].

IC50 & Target[1]

ATM

 

ATR

 

体外研究
(In Vitro)

Antitumor agent-28 inhibits ataxia telangiectasia mutated (ATM; IC50=7.6 nM; HT29 cells), ataxia telangiectasia and Rad3-related protein (ATR; IC50=18 μM; HT29 cells), PI3Ka (IC50=0.24 μM; BT474 cells). Antitumor agent-28 does not inhibit mTOR in MDA-MB-468 cells[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Antitumor agent-28 相关抗体:
分子量

512.62

Formula

C25H32N6O4S
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

Antitumor agent-28 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Antitumor agent-282097499-67-5Antitumor agent28Antitumor agent 28ATM/ATRAtaxia telangiectasia mutatedATM and RAD3 relatedHT29ataxiatelangiectasiaRad3PI3KaBT474MDA-MB-468Inhibitorinhibitorinhibit

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