2. GPCR/G Protein Others
  3. Others Adenosine Receptor
  4. Taminadenant mesylate

Taminadenant mesylate  (Synonyms: NIR178 mesylate; PBF509 mesylate)

目录号: HY-109139A
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摩尔计算器

Taminadenant mesylate (NIR178 mesylate)是一种强效的腺苷A2A受体拮抗剂，具有潜在的抗肿瘤活性。Taminadenant mesylate能够选择性结合并抑制T淋巴细胞上的A2AR，从而解除腺苷/A2AR介导的对T淋巴细胞的抑制，激活针对肿瘤细胞的T细胞介导免疫反应。Taminadenant mesylate通过减少易感肿瘤细胞的增殖来发挥作用。Taminadenant mesylate还显示出在帕金森病模型中逆转运动障碍的有效性，并且能够抑制由L-DOPA引起的运动障碍。

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Taminadenant mesylate Chemical Structure

Taminadenant mesylate Chemical Structure

CAS No. : 2253894-81-2

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Taminadenant mesylate 的其他形式现货产品:

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Taminadenant mesylate 相关抗体

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Adenosine A1 receptor (A1R) Adenosine A2A receptor (A2AR) Adenosine A2B receptor (A2BR) Adenosine A3 receptor (A3R)

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生物活性

Taminadenant mesylate (NIR178 mesylate) is a potent adenosine A2A receptor antagonist with potential anti-tumor activity. Taminadenant mesylate can selectively bind and inhibit A2AR on T lymphocytes, thereby releasing adenosine/A2AR-mediated inhibition of T lymphocytes and activating T cell-mediated immune responses against tumor cells. Taminadenant mesylate works by reducing the proliferation of susceptible tumor cells. Taminadenant mesylate also showed effectiveness in reversing dyskinesias in Parkinson's disease models and was able to inhibit dyskinesias caused by L-DOPA[1].

分子量

402.23

Formula

C11H12BrN7O3S
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

Taminadenant mesylate 相关分类

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  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Taminadenant2253894-81-2NIR178PBF509NIR 178NIR-178PBF 509PBF-509OthersAdenosine ReceptorP1 receptormovement disordersincluding catalepsytremorhemiparkinsonismantitumorInhibitorinhibitorinhibit

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