Cdk12 - cyclin-dependent kinase 12 Gene

中文名称：细胞周期蛋白依赖性激酶 12

种属: Mus musculus

同用名: Crk7; Pksc; Crkrs; D11Ertd752e; 1810022J16Rik

关于 Cdk12

功能概要

该基因编码的蛋白可启动蛋白激酶结合活性。在干细胞分化的负调节上游或负调节中起作用。预测位于核斑点。预测是细胞周期蛋白 K-CDK12 复合物和细胞周期蛋白/CDK 阳性转录延伸因子复合物的一部分。预计活跃于核心。以多种结构表达，包括囊胚；早期胚胎；未来的大脑；原条;和未分段的间充质。与人 CDK12（细胞周期蛋白依赖性激酶 12）同源。 [由基因组资源联盟提供，2022 年 4 月]

Enables protein kinase binding activity. Acts upstream of or within negative regulation of stem cell differentiation. Predicted to be located in nuclear speck. Predicted to be part of cyclin K-CDK12 complex and cyclin/CDK positive transcription elongation factor complex. Predicted to be active in nucleus. Is expressed in several structures, including blastocyst; early embryo; future brain; primitive streak; and unsegmented mesenchyme. Orthologous to human CDK12 (cyclin dependent kinase 12). [provided by Alliance of Genome Resources, Apr 2022]