2. Gene
  3. PRDX2 - peroxiredoxin 2 Gene

PRDX2 - peroxiredoxin 2 Gene

  • 基因
  • 蛋白
  • 疾病
  • 相关产品
  • 直系同源

中文名称：过氧化物酶 2

种属: Homo sapiens

同用名: PRP; TSA; PRX2; PTX1; TPX1; NKEFB; PRXII; TDPX1; NKEF-B; HEL-S-2a

基因 ID: 7001 | 基因类型: protein coding

关于 PRDX2

Cytogenetic location: 19p13.13 Genomic coordinates (GRCh38): 19:12,796,823-12,801,800 (from NCBI)

This gene has 6 transcripts (splice variants), 136 orthologues and 4 paralogues. Ubiquitous expression in bone marrow (RPKM 201.9), heart (RPKM 194.1) and 25 other tissues.

功能概要

该基因编码抗氧化酶过氧化物酶家族的成员，可减少过氧化氢和烷基氢过氧化物。编码的蛋白质在细胞中起着抗氧化保护作用，它可能有助于 CD8 (+) T 细胞的抗病毒活性。该蛋白质的晶体结构已解析为 2.7 埃。这种蛋白质通过稳定血红蛋白来防止氧化应激引起的溶血性贫血，从而使该基因成为溶血性贫血患者的治疗靶点。这种蛋白质可能具有增殖作用，并在癌症发展或进展中发挥作用。已在 5、6、10 和 13 号染色体上鉴定出相关的假基因。[RefSeq 提供，2013 年 3 月]

This gene encodes a member of the peroxiredoxin family of antioxidant Enzymes, which reduce hydrogen peroxide and alkyl hydroperoxides. The encoded protein plays an antioxidant protective role in cells, and it may contribute to the Antiviral activity of CD8(+) T-cells. The crystal structure of this protein has been resolved to 2.7 angstroms. This protein prevents hemolytic anemia from oxidative stress by stabilizing hemoglobin, thus making this gene a therapeutic target for patients with hemolytic anemia. This protein may have a proliferative effect and play a role in Cancer development or progression. Related pseudogenes have been identified on chromosomes 5, 6, 10 and 13. [provided by RefSeq, Mar 2013]

PRDX2 基因产物(1)

mRNA Protein Name
NM_005809.6 NP_005800.3 peroxiredoxin-2
基因本体论
  • 分子功能
  • 生物过程
分子功能 GO 注释 逻辑证据 参考文献 来源
enables antioxidant activity IDA
IDA: 通过直接分析推断
8144038 GOA
enables protein binding IPI
IPI: 通过物理相互作用推断
17557078 GOA
enables thioredoxin peroxidase activity IDA
IDA: 通过直接分析推断
8144038 GOA
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in cellular response to oxidative stress IDA
IDA: 通过直接分析推断
20978343 GOA
involved in defense response to tumor cell IMP
IMP: 通过突变表型推断
30429596 GOA
involved in regulation of apoptotic process IMP
IMP: 通过突变表型推断
12943237 GOA
involved in removal of superoxide radicals IDA
IDA: 通过直接分析推断
20978343 GOA
involved in response to oxidative stress IMP
IMP: 通过突变表型推断
12943237 GOA
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

PRDX2 蛋白结构

AhpC-TSA

AhpC-TSA: AhpC/TSA family (8 - 140)

1-cysPrx_C

1-cysPrx_C: C-terminal domain of 1-Cys peroxiredoxin (161 - 195)

  • 0
  • 100
  • 198 a.a.
蛋白主名 其他名称

peroxiredoxin-2

epididymis secretory sperm binding protein Li 2a

PRDX2 蛋白互作信息

分类
蛋白名称 蛋白编号 互作蛋白 互作蛋白种属 互作蛋白编号 实验方法 参考文献
种属内
PRDX2 P32119 STAT3 Homo sapiens P40763
Pull Down
25402766
种属内
PRDX2 P32119 TXN Homo sapiens P10599
Pull Down
25402766
种属间: 跨种属相互作用 种属内: 同种属相互作用

重组 PRDX2 蛋白

目录号 产品名 蛋白编号 纯度
HY-P71464 Peroxiredoxin-2/PRDX2 Protein, Human (His) P32119 (2A-198N) ≥95%
HY-P73374 Peroxiredoxin-2/PRDX2 Protein, Human (sf9, His) P32119 (M1-N198) ≥95%

PRDX2 抗体

目录号 产品名 应用 反应物种
HY-P81840 Peroxiredoxin 2 Antibody (YA1585) WB, IHC-P Human, Mouse, Rat

关联疾病

疾病名称 别名
Hemolytic Anemia

Anemia, Hemolytic

Anemia Hemolytic

Anaemia Due To Other Disorders Of Glutathione Metabolism

Chronic Non Spherocytic Anaemia

G6pd - [Glucose-6-Phosphate Dehydrogenase Deficiency] Anaemia

Anaemia Due To Glucose-6-Phosphate Dehydrogenase Deficiency

Glucose-6-Phosphate Dehydrogenase Deficiency With Anaemia

Glucose-6-Phosphate Dehydrogenase Deficiency Anaemia

Favism Anaemia

Haemolytic Anaemia Due Tog6pd Deficiency

Favism

Pentose Phosphate Pathway Disorder Anaemia

Anaemia Due To Pentose Phosphate Pathway Defect
Fuchs' Endothelial Dystrophy

Fuchs Endothelial Corneal Dystrophy

Fuchs Endothelial Dystrophy

Fuchs Dystrophy

Fced

Fuchs' Corneal Dystrophy

Fuchs' Endothelial Corneal Dystrophy

Fuchs Atrophy

Fuchs Corneal Dystrophy

Endoepithelial Corneal Dystrophy

Fecd

Late Hereditary Endothelial Dystrophy

Corneal Dystrophy, Fuchs Endothelial

Dystrophy, Corneal, Fuchs Endothelial

Corneal Dystrophy, Fuchs' Endothelial, 1
Hereditary Spherocytosis

Congenital Spherocytic Hemolytic Anemia

Spherocytic Anemia

Congenital Spherocytosis

Spherocytosis, Type 1

Minkowski Chauffard Syndrome

Hs

Minkowski-Chauffard Disease

Minkowski-Chauffard Syndrome

Spherocytosis Hereditary

Spherocytosis, Hereditary

Anemia, Hereditary Spherocytic Hemolytic
Autism Spectrum Disorder

Asd

Autism Spectrum Disorders

Autistic Continuum

Pervasive Developmental Disorder

Pervasive Development Disorder

Autistic Behavior

Autistic Disorder

Autistic

Autistic Disorder Of Childhood Onset

Infantile Autism

Childhood Autism

Kanner Syndrome

Pervasive Developmental Delay Nos

Pervasive Developmental Disorder, Not Otherwise Specified
Autism

Autistic Disorder

Autism Susceptibility 1

Childhood Autism

Autistic Disorder Of Childhood Onset

Infantile Autism

Kanner'S Syndrome

Autistic
疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

相关产品

Approval
生物活性分子 (2)
目录号 产品名 作用方式
纯度 是否罕见病
HY-B1324 Oxiconazole nitrate ≥98.0% 是
HY-B1324A Oxiconazole / 否
Pre-clinical Phase
生物活性分子 (1)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-RS11075 PRDX2 Human Pre-designed siRNA Set A Pre-designed Sets / 否

直系同源

种属 基因名 来源 基因 ID
Mus musculus PRDX2 MGD MGI:109486
Rattus norvegicus PRDX2 RGD RGD:3838
Bos taurus PRDX2 VGNC VGNC:33300
Felis catus PRDX2 VGNC VGNC:69037
Canis familiaris PRDX2 VGNC VGNC:44951
Others PRDX2 NCBI
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