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  2. TEAD3 - TEA domain transcription factor 3 Gene

TEAD3 - TEA domain transcription factor 3 Gene

中文名称:TEA 域转录因子 3

种属: Homo sapiens

同用名: TEF5; TEAD5; TEF-5; DTEF-1; ETFR-1; TEAD-3

基因 ID: 7005 | 基因类型: protein coding

关于 TEAD3

Cytogenetic location: 6p21.31 Genomic coordinates (GRCh38): 6:35,473,597-35,497,079 (from NCBI)

This gene has 3 transcripts (splice variants), 261 orthologues and 3 paralogues. Ubiquitous expression in placenta (RPKM 22.4), endometrium (RPKM 21.2) and 23 other tissues.

功能概要

该基因产物是转录因子转录增强因子 (TEF) 家族的成员,其中包含 TEA/ATTS DNA 结合域。它主要在胎盘中表达,并参与绒毛膜促生长激素 B 基因增强子的反式激活。该蛋白质的翻译起始于非 AUG (AUA) 起始密码子。[RefSeq 提供,2008 年 7 月]

This gene product is a member of the transcriptional enhancer factor (TEF) family of transcription factors, which contain the TEA/ATTS DNA-binding domain. It is predominantly expressed in the placenta and is involved in the transactivation of the chorionic somatomammotropin-B gene enhancer. Translation of this protein is initiated at a non-AUG (AUA) start codon. [provided by RefSeq, Jul 2008]

TEAD3 基因产物(2)

mRNA Protein Name
NM_001395214.1 NP_001382143.1 transcriptional enhancer factor TEF-5 isoform 2
NM_003214.4 NP_003205.2 transcriptional enhancer factor TEF-5 isoform 1
基因本体论
  • 分子功能
  • 生物过程
分子功能 GO 注释 逻辑证据 参考文献 来源
enables DNA-binding transcription factor activity IDA
IDA: 通过直接分析推断
18579750 GOA
enables RNA polymerase II-specific DNA-binding transcription factor binding IPI
IPI: 通过物理相互作用推断
23946438 GOA
enables protein binding IPI
IPI: 通过物理相互作用推断
16189514 GOA
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in asymmetric neuroblast division IGI
IGI: 通过遗传相互作用推断
23946438 GOA
involved in hippo signaling IDA
IDA: 通过直接分析推断
18579750 GOA
EXP:通过实验结果推断 IDA:通过直接分析推断 IPI:通过物理相互作用推断 IMP:通过突变表型推断 IGI:通过遗传相互作用推断 IEP:通过表达模式推断

TEAD3 蛋白结构

TEA

TEA: TEA/ATTS domain family (8 - 427)

  • 0
  • 100
  • 200
  • 300
  • 400
  • 435 a.a.
蛋白主名 其他名称

transcriptional enhancer factor TEF-5

TEA domain family member 3

TEAD3 蛋白互作信息

分类
蛋白名称 蛋白编号 互作蛋白 互作蛋白种属 互作蛋白编号 实验方法 参考文献
Intra TEAD3 Q99594 VGLL2 Homo sapiens Q8N8G2
Validated Y2H
25416956
Intra TEAD3 Q99594 VGLL2 Homo sapiens Q8N8G2
Y2H Array
25416956
Intra TEAD3 Q99594 VGLL2 Homo sapiens Q8N8G2
Y2H Prey Pooling
25416956
Intra TEAD3 Q99594 VGLL1 Homo sapiens Q99990
Validated Y2H
32296183
Intra TEAD3 Q99594 VGLL1 Homo sapiens Q99990
Y2H Array
20211142
Intra TEAD3 Q99594 WWTR1 Homo sapiens Q9GZV5
Y2H Pooling
16189514
Intra TEAD3 Q99594 WWTR1 Homo sapiens Q9GZV5
Y2H Array
31515488
种属间: 跨种属相互作用 种属内: 同种属相互作用

重组 TEAD3 蛋白

目录号 产品名 蛋白编号 纯度
HY-P71626 TEAD3 Protein, Human (His-SUMO) Q99594 (M112-D435) ≥95%

关联疾病

疾病名称 别名
Skin Carcinoma In Situ

Carcinoma In Situ Of Skin

Cutaneous Carcinoma In Situ

Sveinsson Chorioretinal Atrophy

SCRA

Atrophia Areata

Helicoid Peripapillary Chorioretinal Degeneration

Hpcd

Aa

Peripapillary Chorioretinal Degeneration, Icelandic Type

Helicoidal Peripapillary Chorioretinal Degeneration

Atrophy, Chorioretinal, Sveinsson

疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

直系同源

种属 基因名 来源 基因 ID
Rattus norvegicus TEAD3 RGD RGD:1311583
Mus musculus TEAD3 MGD MGI:109241
Bos taurus TEAD3 VGNC VGNC:35726
Macaca mulatta TEAD3 VGNC VGNC:78303
Felis catus TEAD3 VGNC VGNC:66055
Canis familiaris TEAD3 VGNC VGNC:47230
Others TEAD3 NCBI