1. Gene
  2. TMPRSS2 - transmembrane serine protease 2 Gene

TMPRSS2 - transmembrane serine protease 2 Gene

中文名称:跨膜丝氨酸蛋白酶 2

种属: Homo sapiens

同用名: PRSS10

基因 ID: 7113 | 基因类型: protein coding

关于 TMPRSS2

Cytogenetic location: 21q22.3 Genomic coordinates (GRCh38): 21:41,464,305-41,508,158 (from NCBI)

This gene has 20 transcripts (splice variants), 229 orthologues, 17 paralogues and is associated with 72 phenotypes. Biased expression in prostate (RPKM 167.2), colon (RPKM 59.9) and 10 other tissues.

功能概要

该基因编码属于丝氨酸蛋白酶家族的蛋白质。编码的蛋白质包含 II 型跨膜结构域、A 类受体结构域、清道夫受体富含半胱氨酸结构域和蛋白酶结构域。已知丝氨酸蛋白酶参与许多生理和病理过程。该基因被证明在前列腺癌细胞中被雄激素上调,在雄激素非依赖性前列腺癌组织中被下调。这种蛋白质的蛋白酶结构域被认为在自动切割后被切割并分泌到细胞培养基中。这种蛋白质还通过蛋白水解切割和激活病毒包膜糖蛋白来促进病毒进入宿主细胞。被发现使用这种蛋白质进入细胞的病毒包括流感病毒和人类冠状病毒 HCoV-229E、MERS-CoV、SARS-CoV 和 SARS-CoV-2 (COVID-19 病毒) 。已发现该基因编码不同亚型的可变剪接转录物变体。[RefSeq 提供,2020 年 4 月]

This gene encodes a protein that belongs to the serine Protease family. The encoded protein contains a type II transmembrane domain, a receptor class A domain, a scavenger receptor cysteine-rich domain and a Protease domain. Serine proteases are known to be involved in many physiological and pathological processes. This gene was demonstrated to be up-regulated by androgenic Hormones in prostate Cancer cells and down-regulated in androgen-independent prostate Cancer tissue. The Protease domain of this protein is thought to be cleaved and secreted into cell media after autocleavage. This protein also facilitates entry of viruses into host cells by proteolytically cleaving and activating viral envelope glycoproteins. Viruses found to use this protein for cell entry include Influenza Virus and the human coronaviruses HCoV-229E, MERS-CoV, SARS-CoV and SARS-CoV-2 (COVID-19 virus). Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Apr 2020]

TMPRSS2 基因产物(3)

mRNA Protein Name
NM_001135099.1 NP_001128571.1 transmembrane protease serine 2 isoform 1
NM_001382720.1 NP_001369649.1 transmembrane protease serine 2 isoform 3
NM_005656.4 NP_005647.3 transmembrane protease serine 2 isoform 2
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables protein binding IPI
IPI: 通过物理相互作用推断
21068237 GOA
enables serine-type endopeptidase activity IDA
IDA: 通过直接分析推断
25122198 GOA
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in positive regulation of viral entry into host cell IDA
IDA: 通过直接分析推断
21068237 GOA
involved in protein autoprocessing IMP
IMP: 通过突变表型推断
21068237 GOA
involved in proteolysis IDA
IDA: 通过直接分析推断
21068237 GOA
细胞组分 GO 注释 逻辑证据 参考文献 来源
located in plasma membrane IDA
IDA: 通过直接分析推断
21068237 GOA
EXP:通过实验结果推断 IDA:通过直接分析推断 IPI:通过物理相互作用推断 IMP:通过突变表型推断 IGI:通过遗传相互作用推断 IEP:通过表达模式推断

TMPRSS2 蛋白结构

SRCR_2

SRCR_2: Scavenger receptor cysteine-rich domain (190 - 283)

Trypsin

Trypsin: Trypsin (293 - 521)

  • 0
  • 100
  • 200
  • 300
  • 400
  • 500
  • 529 a.a.
蛋白主名 其他名称

transmembrane protease serine 2

epitheliasin

重组 TMPRSS2 蛋白

目录号 产品名 蛋白编号 纯度
HY-P72043 TMPRSS2 Protein, Human (P.pastoris, His) O15393 (W106-G492) ≥95%
HY-P72044 TMPRSS2 Protein, Human (R255Q, HEK293, His) O15393-1 (W106-G492, R255Q) ≥95%

关联疾病

疾病名称 别名
Covid-19

2019 Novel Coronavirus

2019-Ncov Infection

Covid19

Sars-Cov-2 Infection

Wuhan Coronavirus Infection

Wuhan Seafood Market Pneumonia Virus Infection

Influenza

Flu

Influenza With Non-Respiratory Manifestation

Influenza With Other Manifestations

Influenza, Human

Influenza, Susceptibility To

Seasonal Influenza, Virus Identified

Middle East Respiratory Syndrome

Mers

Mers - [Middle East Respiratory Syndrome]

Severe Acute Respiratory Syndrome

Sars

Sars-Cov Infection

Sars-1

Sar Deficiency

Sars - [Severe Acute Respiratory Syndrome]

Coronavirus Infectious Disease
Prostate Cancer

Prostate Carcinoma

Prostate Cancer, Familial

Prostate Neoplasm

Prostate Cancer, Somatic

Prostate Cancer, Susceptibility To

Prostatic Cancer

Prostatic Neoplasms

Hereditary Prostate Cancer

Prostatic Neoplasm

Cancer Of Prostate

Carcinoma Of Prostate

Familial Prostate Cancer

Familial Prostate Carcinoma

Malignant Tumor Of Prostate

Malignant Neoplasm Of Prostate

Prostate Cancer, Familial, Susceptibility To

Malignant Tumor Of The Prostate

Ngp - New Growth Of Prostate

Tumor Of The Prostate

Prostate Cancer, Hereditary

Cancer Of The Prostate

Malignant Neoplasm Of The Prostate

Prostatic Carcinoma

PC

Prca

Cancer, Prostate

Malignant Prostatic Tumour

Malignant Tumour Of Prostate

Primary Prostate Cancer

Primary Malignant Neoplasm Of Prostate

Prostate Gland Cancer

Long Covid

Post-Acute Sequelae Of Sars-Cov-2 Infection

Chronic Covid-19

Pasc

Post-Covid Syndrome

Critical Covid-19
Acute Hemorrhagic Conjunctivitis

Viral Conjunctivitis

Conjunctivitis, Acute Hemorrhagic

Apollo Disease

Epidemic Hemorrhagic Conjunctivitis

Viral Conjunctiva Disorder

Viral Conjunctivitis Nos

Severe Covid-19
Viral Pneumonia

Pneumonia, Viral

Acute Viral Pneumonia

Bronchopneumonia Due To Viruses Other Than Influenza Viruses

Interstitial Viral Pneumonia

Viral Bronchopneumonia

Viral Double Pneumonia

Viral Lobar Pneumonia

Viral Purulent Pneumonia

Virus Interstitial Pneumonia

Virus Lobar Pneumonia

Ebola Hemorrhagic Fever

Ebola Virus Disease

Viral Hemorrhagic Fever

Hemorrhagic Fever, Ebola

Ebola

Ehf

Ebola Fever

Hemorrhagic Fevers, Viral

Ebola Haemorrhagic Fever

Ebod - [Ebola Disease]

Evd - [Ebola Virus Disease]

Ebola Virus Haemorrhagic Fever

Vhf - [Viral Haemorrhagic Fever] Nos

Viral Haemorrhagic Fever, Not Otherwise Specified

Non-Severe Covid-19
Orchitis

Inflammation Of Testis

Orchititis

Mumps Orchitis

Androgenic Alopecia

Androgenetic Alopecia

Alopecia Androgenetica, Male Pattern Baldness

Prostatic Acinar Adenocarcinoma

Acinar Prostate Adenocarcinoma

Avian Influenza

Bird Flu

Influenza In Birds

Avian Flu

Miller Fisher Syndrome

Cranial Variant Of Gbs

Fisher'S Syndrome

Miller-Fisher Variant Of Guillain-Barre Syndrome

Miller-Fisher Syndrome

Cranial Variant Of Guillain-Barré Syndrome

Cranial Variant Of Guillain-Barre Syndrome

Fisher Syndrome

Prostate Neuroendocrine Neoplasm

Neuroendocrine Tumor Of The Prostate

Peptic Esophagitis

Reflux Esophagitis

Peptic Reflux Disease

Reflux Oesophagitis

Esophagitis, Peptic

Gastro-Esophageal Reflux Disease With Esophagitis

Subacute Thyroiditis

Giant-Cell Thyroiditis

Granulomatous Thyroiditis

Subacute Granulomatous Thyroiditis

De Quervain'S Thyroiditis

Thyroiditis Subacute

Thyroiditis, Subacute

Pseudogranulomatous Thyroiditis

De Quervain Thyroiditis

Nonsuppurative Subacute Thyroiditis

Pseudotuberculous Thyroiditis

Nonsuppurative Thyroiditis Nos

Common Cold

Acute Coryza

Acute Nasopharyngitis

Acute Rhinitis

Acute Viral Rhinopharyngitis

Nasopharyngitis - Acute

Nasopharyngitis, Acute

Rhino-Sinusitis

Rhinosinusitis

Common Colds

Acute Infective Rhinitis

Cold

Coryza

Head Cold

Infective Nasopharyngitis

Rhinopharyngitis

Acute Nasal Catarrh

Infective Rhinitis

Acute Nasopharyngeal Catarrh

Infective Nasopharyngitis Nos

Nasopharyngitis Nos

Epipharyngitis

Mucositis Nos

Inflammatory Disease Of Mucous Membrane

Mucosal Inflammation

Conjunctival Disease

Conjunctival Diseases

Conjunctival Disorder

Suppression Of Tumorigenicity 12

Prostate Adenocarcinoma

Adenocarcinoma Of Prostate

ST12

Prostate Adenocarcinoma 1

Pac1

Herpangina

Vesicular Pharyngitis

Acute Dacryoadenitis
Adult Respiratory Distress Syndrome

Acute Respiratory Distress Syndrome

Ards

Non-Cardiogenic Pulmonary Edema

Acute Lung Injury

Respiratory Distress Syndrome, Adult

Shock Lung

Acute Respiratory Distress

Respiratory Distress Syndrome

Adult Rds

Ali

Increased-Permeability Pulmonary Edema

Stiff Lung

Respiratory Distress Syndrome Adult

Pulmonary Artery Disease

Abnormality Of The Pulmonary Artery

Respiratory Failure

Acute Respiratory Failure

Chronic Respiratory Failure

Respiratory Insufficiency

Acute-On-Chronic Respiratory Failure

Respiratory Disease

Acute And Chronic Respiratory Failure

Respiratory Insufficiency/Failure

Chronic Respiratory Disease

Pulmonary Valve Insufficiency

Chronic Disease Of Respiratory System

Respiration Disorders

Respiratory Tract Diseases

Lung Failure Nos

Pulmonary Failure

Arf - [Acute Respiratory Failure]

Acute Respiratory Insufficiency

Acute Pulmonary Insufficiency

Acute Respiration Failure

Chronic Respiration Failure

Extrinsic Cardiomyopathy
Lipoprotein Quantitative Trait Locus

Coronary Artery Disease

Coronary Artery Anomaly

Coronary Artery Disease, Susceptibility To

Myocardial Ischemia

Congenital Anomaly Of Coronary Artery

Coronary Arteriosclerosis

Coronary Disease

Coronary Heart Disease

Coronary Artery Disorder

LPAQTL

Lpa Deficiency, Congenital

Coronary Artery Abnormality

Coronary Artery Anomaly, Congenital

Chd

Coronary Syndrome

Congenital Malformations Of Coronary Vessels

Malformation Of Coronary Vessels

Congenital Coronary Artery Anomaly

Congenital Coronary Artery Deformity

Congenital Coronary Artery Disorder

Abnormal Coronary Artery

Congenital Coronary Artery Malposition

Congenital Coronary Disease

Congenital Anomaly Of Coronary Arteries

Hypertension, Essential

Essential Hypertension

Hypertension

High Blood Pressure

Hypertension, Essential, Susceptibility To

Hypertensive Disease

Primary Hypertension

EHT

Hypertension, Salt-Sensitive Essential, Susceptibility To

Hyperpiesia

Idiopathic Hypertension

Hypertensive Disorder

Hypertension, Essential, Susceptibility To, 3

Hypertension, Essential 3

Hypertension, Essential, Salt-Sensitive

Hypertension, Essential, Susceptibility To, 6

Hypertension, Essential 6

Hypertension, Salt-Sensitive Essential

Hypertension, Susceptibility To

Hypertension, Essential, Susceptibility To, 4

Hypertension, Essential 4

Hypertension, Essential, Susceptibility To, 2

Hypertension, Essential 2

Hypertension, Essential, Susceptibility To, 1

Hypertension, Essential 1

Hypertension, Essential, Susceptibility To, 5

Hypertension, Essential 5

Htn

Vascular Hypertensive Disorder

Systemic Primary Arterial Hypertension

Hbp - [High Blood Pressure]

Systemic Arterial Hypertensive Disorder

Elevated Blood Pressure

Arterial Hypertension Nos

Hypertension Nos

Benign Hypertension

Systemic Arterial Hypertension

Systemic Hypertension

Artery Htn

Benign Htn

Vascular Htn

Vascular Hypertension

Cholesterol Hypertension

Cholesterol Htn

Idiopathic Htn

Malignant Hypertension

Malignant Htn

Raised Blood Pressure

Cardiovascular Hypertension

Primary Htn - [Hypertension]

High Arterial Tension

High Blood Pressure Disorder

Ht - [Hypertension]

Htn - [Hypertension]

Hypertensive Vascular Disease

Hypertensive Vascular Degeneration

Retinitis Pigmentosa

RP

Rod-Cone Dystrophy

Autosomal Recessive Retinitis Pigmentosa

Non-Syndromic Retinitis Pigmentosa

Pericentral Pigmentary Retinopathy

Pigmentary Retinopathy

Tapetoretinal Degeneration

Rcd

Retinitis Pigmentosa Autosomal Recessive

ARRP

Retinitis Pigmentosa, Autosomal Recessive

Retinitis Pigmentosa 1

疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

直系同源

种属 基因名 来源 基因 ID
Macaca mulatta TMPRSS2 VGNC VGNC:78575
Canis familiaris TMPRSS2 VGNC VGNC:53045
Bos taurus TMPRSS2 VGNC VGNC:36140
Felis catus TMPRSS2 VGNC VGNC:66385
Mus musculus TMPRSS2 MGD MGI:1354381
Others TMPRSS2 NCBI