2. Gene
  3. TPP2 - tripeptidyl peptidase 2 Gene

TPP2 - tripeptidyl peptidase 2 Gene

  • 基因
  • 蛋白
  • 疾病
  • 相关产品
  • 直系同源

中文名称：三肽基肽酶 2

种属: Homo sapiens

同用名: IMD78; TPP-2; TPPII; TPP-II

基因 ID: 7174 | 基因类型: protein coding

关于 TPP2

Cytogenetic location: 13q33.1 Genomic coordinates (GRCh38): 13:102,596,986-102,679,958 (from NCBI)

This gene has 29 transcripts (splice variants), 196 orthologues, 9 paralogues and is associated with 3 phenotypes. Ubiquitous expression in testis (RPKM 27.4), thyroid (RPKM 15.8) and 25 other tissues.

功能概要

该基因编码一种哺乳动物肽酶，该酶在中性 pH 值下从较长肽的 N 末端去除三肽。该蛋白质具有对某些 MHC I 类抗原呈递必不可少的特殊功能。该蛋白是一种高分子量丝氨酸外肽酶；活性位点丝氨酸残基周围的氨基酸序列类似于枯草杆菌蛋白酶类而非胰蛋白酶类的肽酶。[RefSeq 提供，2008 年 7 月]

This gene encodes a mammalian peptidase that, at neutral pH, removes tripeptides from the N terminus of longer Peptides. The protein has a specialized function that is essential for some MHC class I antigen presentation. The protein is a high molecular mass serine exopeptidase; the amino acid sequence surrounding the serine residue at the active site is similar to the peptidases of the subtilisin class rather than the trypsin class. [provided by RefSeq, Jul 2008]

TPP2 基因产物(3)

mRNA Protein Name
NM_001330588.2 NP_001317517.1 tripeptidyl-peptidase 2 isoform 2
NM_001367947.1 NP_001354876.1 tripeptidyl-peptidase 2 isoform 3
NM_003291.4 NP_003282.2 tripeptidyl-peptidase 2 isoform 1
基因本体论
  • 分子功能
  • 生物过程
分子功能 GO 注释 逻辑证据 参考文献 来源
enables aminopeptidase activity EXP
EXP: 通过实验结果推断
9668046 GOA
enables aminopeptidase activity IMP
IMP: 通过突变表型推断
25525876 GOA
enables identical protein binding IPI
IPI: 通过物理相互作用推断
22483107 GOA
enables protein binding IPI
IPI: 通过物理相互作用推断
25416956 GOA
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in intracellular amino acid homeostasis IMP
IMP: 通过突变表型推断
25525876 GOA
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

TPP2 蛋白结构

Peptidase_S8

Peptidase_S8: Subtilase family (40 - 509)

TPPII

TPPII: Tripeptidyl peptidase II (773 - 966)

  • 0
  • 200
  • 400
  • 600
  • 800
  • 1000
  • 1249 a.a.
蛋白主名 其他名称

tripeptidyl-peptidase 2

tripeptidyl aminopeptidase

TPP2 蛋白互作信息

分类
蛋白名称 蛋白编号 互作蛋白 互作蛋白种属 互作蛋白编号 实验方法 参考文献
种属内
TPP2 P29144 POLB Homo sapiens P06746
Y2H Array
25416956
种属内
TPP2 P29144 EHHADH Homo sapiens Q08426
Y2H Array
31515488
种属内
TPP2 P29144 EHHADH Homo sapiens Q08426
Y2H Prey Pooling
25416956
种属内
TPP2 P29144 POLB Homo sapiens P06746
Y2H Prey Pooling
25416956
种属内
TPP2 P29144 EHHADH Homo sapiens Q08426
Validated Y2H
25416956
种属内
TPP2 P29144 PPP1R16A Homo sapiens Q96I34
Y2H Array
25416956
种属内
TPP2 P29144 EHHADH Homo sapiens Q08426
Y2H Array
25416956
种属内
TPP2 P29144 POLB Homo sapiens P06746
Y2H Array
31515488
种属间: 跨种属相互作用 种属内: 同种属相互作用

重组 TPP2 蛋白

目录号 产品名 蛋白编号 纯度
HY-P71451 TPP2 Protein, Human (Myc, His) P29144 (44D-264H) ≥95%

关联疾病

疾病名称 别名
Immunodeficiency 78 With Autoimmunity And Developmental Delay

IMD78

Tpp2 Deficiency

Autoimmune Hemolytic Anemia-Autoimmune Thrombocytopenia-Primary Immunodeficiency Syndrome

Evans Syndrome Associated With Primary Immunodeficiency

Tppii Deficiency

Tppii-Related Immunodeficiency, Autoimmunity, And Neurodevelopmental Delay With Impaired Glycolysis And Lysosomal Expansion Disease

Triangle Disease

Tripeptidyl-Peptidase Ii Deficiency
Thrombocytopenia

Low Platelet Count

Low Platelets

Decreased Platelets

Platelet Dysfunction Nos
Evans' Syndrome

Evans Syndrome

Autoimmune Hemolytic Anemia And Autoimmune Thrombocytopenia

Evan Syndrome

Immune Pancytopenia

Evan'S Syndrome
Herpetic Whitlow

Herpetic Felon
Hemolytic Anemia

Anemia, Hemolytic

Anemia Hemolytic

Anaemia Due To Other Disorders Of Glutathione Metabolism

Chronic Non Spherocytic Anaemia

G6pd - [Glucose-6-Phosphate Dehydrogenase Deficiency] Anaemia

Anaemia Due To Glucose-6-Phosphate Dehydrogenase Deficiency

Glucose-6-Phosphate Dehydrogenase Deficiency With Anaemia

Glucose-6-Phosphate Dehydrogenase Deficiency Anaemia

Favism Anaemia

Haemolytic Anaemia Due Tog6pd Deficiency

Favism

Pentose Phosphate Pathway Disorder Anaemia

Anaemia Due To Pentose Phosphate Pathway Defect
Ras-Associated Autoimmune Leukoproliferative Disorder

RALD

Autoimmune Lymphoproliferative Syndrome Type 4

Alps4

Autoimmune Lymphoproliferative Syndrome, Type Iv

Ras-Associated Autoimmune Leukoproliferative Disease

Ras-Associated Autoimmune Lymphoproliferative Syndrome Type Iv, Somatic

Alps Type 4

Alps Type Iv

Autoimmune Lymphoproliferative Syndrome Type Iv

Autoimmune Lymphoproliferative Syndrome 4
Epidermodysplasia Verruciformis 1

Epidermodysplasia Verruciformis

Epidermodysplasia Verruciformis, Susceptibility To, 1

Lutz-Lewandowsky Epidermodysplasia Verruciformis

EV1

Lewandowsky-Lutz Syndrome

Ev
疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

相关产品

Pre-clinical Phase
生物活性分子 (1)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-RS14943 TPP2 Human Pre-designed siRNA Set A Pre-designed Sets / 否

直系同源

种属 基因名 来源 基因 ID
Canis familiaris TPP2 VGNC VGNC:47748
Felis catus TPP2 VGNC VGNC:66481
Mus musculus TPP2 MGD MGI:102724
Bos taurus TPP2 VGNC VGNC:36257
Macaca mulatta TPP2 VGNC VGNC:78637
Rattus norvegicus TPP2 RGD RGD:621584
Others TPP2 NCBI
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