TRPC4 - transient receptor potential cation channel subfamily C member 4 Gene

中文名称：瞬时受体电位阳离子通道亚家族 C 成员 4

种属: Homo sapiens

同用名: TRP4; HTRP4; HTRP-4

基因 ID: 7223 | 基因类型: protein coding

关于 TRPC4

Cytogenetic location: 13q13.3 Genomic coordinates (GRCh38): 13:37,632,063-37,869,772 (from NCBI)

This gene has 10 transcripts (splice variants), 279 orthologues and 5 paralogues. Biased expression in endometrium (RPKM 6.2), prostate (RPKM 2.5) and 8 other tissues.

功能概要

该基因编码瞬时受体电位阳离子通道的典型亚科成员。编码的蛋白质形成一个非选择性钙渗透性阳离子通道，该通道被 Gq 偶联受体和酪氨酸激酶激活，并在内皮渗透性、血管舒张、神经递质释放和细胞增殖等多个过程中发挥作用。该基因的单核苷酸多态性可能与光敏性全身性癫痫有关。已经观察到该基因编码多种亚型的可变剪接转录物变体。[RefSeq 提供，2011 年 8 月]

This gene encodes a member of the canonical subfamily of transient receptor potential cation channels. The encoded protein forms a non-selective calcium-permeable cation channel that is activated by Gq-coupled receptors and tyrosine kinases, and plays a role in multiple processes including endothelial permeability, vasodilation, neurotransmitter release and cell proliferation. Single nucleotide polymorphisms in this gene may be associated with generalized epilepsy with photosensitivity. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Aug 2011]

TRPC4 基因产物(9)

mRNA	Protein	Name
NM_001135955.3	NP_001129427.1	short transient receptor potential channel 4 isoform beta
NM_001135956.3	NP_001129428.1	short transient receptor potential channel 4 isoform gamma
NM_001135957.3	NP_001129429.1	short transient receptor potential channel 4 isoform delta
NM_001135958.3	NP_001129430.1	short transient receptor potential channel 4 isoform zeta
NM_001354799.2	NP_001341728.1	short transient receptor potential channel 4 isoform eta
NM_001354806.2	NP_001341735.1	short transient receptor potential channel 4 isoform eta
NM_001372055.1	NP_001358984.1	short transient receptor potential channel 4 isoform eta
NM_003306.3	NP_003297.1	short transient receptor potential channel 4 isoform epsilon
NM_016179.4	NP_057263.1	short transient receptor potential channel 4 isoform alpha

基因本体论

分子功能
生物过程
细胞组分

分子功能 GO 注释	逻辑证据	参考文献	来源
enables beta-catenin binding	IPI IPI: 通过物理相互作用推断	19996314	GOA
enables cadherin binding	IPI IPI: 通过物理相互作用推断	19996314	GOA
enables protein binding	IPI IPI: 通过物理相互作用推断	15757897	GOA
enables store-operated calcium channel activity	IMP IMP: 通过突变表型推断	16254212	GOA

生物过程 GO 注释	逻辑证据	参考文献	来源
involved in calcium ion import	IDA IDA: 通过直接分析推断	19996314	GOA

细胞组分 GO 注释	逻辑证据	参考文献	来源
located in basolateral plasma membrane	IDA IDA: 通过直接分析推断	19996314	GOA
part of calcium channel complex	IDA IDA: 通过直接分析推断	20164195	GOA
located in cell surface	IDA IDA: 通过直接分析推断	19996314	GOA
colocalizes with cell-cell junction	IDA IDA: 通过直接分析推断	19996314	GOA
located in cortical cytoskeleton	IDA IDA: 通过直接分析推断	16254212	GOA
located in plasma membrane	IDA IDA: 通过直接分析推断	16254212	GOA

EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

TRPC4 蛋白结构

Ank_2

Ank

TRP_2

Ion_trans

0
200
400
600
800
977 a.a.

蛋白主名

其他名称

short transient receptor potential channel 4

trp-related protein 4

TRPC4 蛋白互作信息

分类	蛋白名称	蛋白编号	互作蛋白	互作蛋白种属	互作蛋白编号	实验方法	参考文献
种属内	TRPC4	Q9UBN4	MX1	Homo sapiens	P20591	Anti Tag CoIP	15757897

种属间: 跨种属相互作用 种属内: 同种属相互作用

关联疾病

疾病名称

别名

Mutilating Palmoplantar Keratoderma With Periorificial Keratotic Plaques

Olmsted Syndrome	Mutilating Palmoplantar Hyperkeratosis With Periorificial Keratotic Plaques
Palmoplantar And Periorificial Keratoderma	Olms

Oculoectodermal Syndrome

Aplasia Cutis Congenita With Epibulbar Dermoids	Toriello-Lacassie-Droste Syndrome
Oculoectodermal Syndrome, Somatic	OES
Aplasia Cutis Congenita-Epibulbar Dermoids Syndrome	Oculo-Ectodermal Syndrome
Toriello Lacassie Droste Syndrome

Darier-White Disease

Keratosis Follicularis	Darier Disease
Darier'S Disease	DAR
DD	Darier White Disease
Darier Disease Acral Hemorrhagic Type	Darier Disease Segmental
Darier Disease, Acral Hemorrhagic Type	Darier Disease, Segmental

Epilepsy

Epilepsy Syndrome	Epileptic Syndrome
Epilepsies	Symptomatic Epilepsies
Post Traumatic Epilepsy	Traumatic Epilepsy
Traumatic Epileptic	Epilepsy Due To Hippocampal Sclerosis
Epilepsy With Ammon'S Horn Sclerosis	Epilepsy Due To Cortical Dysplasia
Epilepsy Due To Neuronal Migration Disorders

Immunodeficiency 10

Immune Dysfunction With T-Cell Inactivation Due To Calcium Entry Defect 2	Combined Immunodeficiency Due To Stim1 Deficiency
IMD10	Stim1 Deficiency
Cid Due To Stim1 Deficiency	Immune Dysfunction, With T-Cell Inactivation Due To Calcium Entry Defect 2
Immunodeficiency, Type 10

T Cell And Nk Cell Immunodeficiency

Photosensitive Epilepsy

Pse	Photogenic Epilepsy
Photoparoxysmal Response	Reflex Epilepsy, Photosensitive
Photoparoxysmal Response 1

Autosomal Dominant Polycystic Kidney Disease

Polycystic Kidney Disease, Adult Type	Adpkd
Polycystic Kidney Diseases	Polycystic Kidney, Autosomal Dominant
Congenital Biliary Ectasias	Polycystic Kidney And Hepatic Disease 1
Polycystic Kidney Disease, Autosomal Dominant	Kidney, Polycystic, Disease, Autosomal Dominant
Adult Polycystic Kidney Disease	Polycystic Kidney, Adult Type
Apckd - [Autosomal Polycystic Kidney Disease]

疾病名称	别名
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

目录号	产品名	作用方式	纯度	Phase
HY-162584	TRPC4/5-IN-2	Inhibitor	/	Phase 2

Cat. No.	产品名	作用方式	纯度	是否罕见病
HY-101507	Zerencotrep	Inhibitor	99.40%	否
HY-12949	ML204	Inhibitor	99.08%	否
HY-133168	Englerin A	Activator	99.50%	否
HY-122051	AC1903	Inhibitor	99.80%	否
HY-112302	HC-070	Antagonist	99.73%	否
HY-12949A	ML204 hydrochloride	Inhibitor	99.74%	否
HY-132813	Evifacotrep	Antagonist	99.55%	否
HY-144429	TRPC5-IN-4	Inhibitor	/	否
HY-146155	TRPC4/5-IN-1	Inhibitor	/	否
HY-162090	TRPC antagonist 1	Antagonist	/	否
HY-RS15106	TRPC4 Human Pre-designed siRNA Set A	Pre-designed Sets	/	否
HY-RS15107	TRPC4AP Human Pre-designed siRNA Set A	Pre-designed Sets	/	否
HY-110379	M084 hydrochloride	Inhibitor	/	否

直系同源

种属	基因名	来源	基因 ID
Bos taurus	TRPC4	VGNC	VGNC:36383
Mus musculus	TRPC4	MGD	MGI:109525
Canis familiaris	TRPC4	VGNC	VGNC:47868
Macaca mulatta	TRPC4	VGNC	VGNC:106307
Rattus norvegicus	TRPC4	RGD	RGD:621276
Felis catus	TRPC4	VGNC	VGNC:66583
Others	TRPC4	NCBI

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上海工商

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沪(浦)应急管危经许[2021]201709(QFYS)

营业执照（三证合一）

TRPC4 - transient receptor potential cation channel subfamily C member 4 Gene

关于 TRPC4

功能概要

TRPC4 基因产物(9)

TRPC4 蛋白结构

TRPC4 蛋白互作信息

关联疾病

直系同源

热门区域

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TRPC4 - transient receptor potential cation channel subfamily C member 4 Gene

关于 TRPC4

功能概要

TRPC4 基因产物(9)

TRPC4 蛋白结构

TRPC4 蛋白互作信息

关联疾病

相关产品

直系同源

热门区域

A

B

C

F

G

H

J

L

N

Q

S

T

X

Y

Z