TUBA4A - tubulin alpha 4a Gene

中文名称：微管蛋白α4a

种属: Homo sapiens

同用名: ALS22; TUBA1; H2-ALPHA

基因 ID: 7277 | 基因类型: protein coding

关于 TUBA4A

Cytogenetic location: 2q35 Genomic coordinates (GRCh38): 2:219,249,710-219,254,740 (from NCBI)

This gene has 10 transcripts (splice variants), 441 orthologues, 23 paralogues and is associated with 1 phenotype. Broad expression in skin (RPKM 72.2), brain (RPKM 48.6) and 20 other tissues.

功能概要

真核细胞骨架的微管执行重要且多样的功能，由 alpha 和 beta 微管蛋白的异二聚体组成。编码这些微管成分的基因是微管蛋白超家族的一部分，该超家族由六个不同的家族组成。来自 alpha、beta 和 gamma 微管蛋白家族的基因存在于所有真核生物中。 α 和β 微管蛋白代表微管的主要成分，而γ 微管蛋白在微管组装的成核过程中起着关键作用。存在多个 α 和 β 微管蛋白基因，它们在物种之间高度保守。该基因编码的α微管蛋白是大鼠睾丸特异性α微管蛋白的高度保守同系物。已发现该基因编码不同亚型的可变剪接转录物变体。[RefSeq 提供，2013 年 6 月]

Microtubules of the eukaryotic Cytoskeleton perform essential and diverse functions and are composed of a heterodimer of alpha and beta tubulin. The genes encoding these microtubule constituents are part of the tubulin superfamily, which is composed of six distinct families. Genes from the alpha, beta and gamma tubulin families are found in all eukaryotes. The alpha and beta tubulins represent the major components of microtubules, while gamma tubulin plays a critical role in the nucleation of microtubule assembly. There are multiple alpha and beta tubulin genes and they are highly conserved among and between species. This gene encodes an alpha tubulin that is a highly conserved homolog of a rat testis-specific alpha tubulin. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jun 2013]

TUBA4A 基因产物(2)

mRNA	Protein	Name
NM_001278552.2	NP_001265481.1	tubulin alpha-4A chain isoform 2
NM_006000.3	NP_005991.1	tubulin alpha-4A chain isoform 1

基因本体论

分子功能
细胞组分

分子功能 GO 注释	逻辑证据	参考文献	来源
enables protein binding	IPI IPI: 通过物理相互作用推断	16455083	GOA
enables protein kinase binding	IPI IPI: 通过物理相互作用推断	24327345	GOA

细胞组分 GO 注释	逻辑证据	参考文献	来源
located in cytoskeleton	IDA IDA: 通过直接分析推断	24327345	GOA
located in microtubule	IDA IDA: 通过直接分析推断	21525035	GOA

EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

TUBA4A 蛋白结构

Tubulin

Tubulin_C

0
100
200
300
400
448 a.a.

蛋白主名

其他名称

tubulin alpha-4A chain

tubulin H2-alpha

TUBA4A 蛋白互作信息

分类	蛋白名称	蛋白编号	互作蛋白	互作蛋白种属	互作蛋白编号	实验方法	参考文献
种属内	TUBA4A	P68366	TCP11L2	Homo sapiens	Q8N4U5	Anti Tag CoIP	33961781
种属内	TUBA4A	P68366	TCP11L2	Homo sapiens	Q8N4U5	Anti Tag CoIP	28514442
种属内	TUBA4A	P68366	TCP11L2	Homo sapiens	Q8N4U5	Validated Y2H	32296183
种属内	TUBA4A	P68366	POC5	Homo sapiens	Q8NA72	Anti Tag CoIP	30845169
种属内	TUBA4A	P68366	POC5	Homo sapiens	Q8NA72	Confocal	30845169
种属内	TUBA4A	P68366	CLIP1	Homo sapiens	P30622	Affinity Chrom	16455083
种属内	TUBA4A	P68366	CLIP1	Homo sapiens	P30622	Saturation Binding	16455083

种属间: 跨种属相互作用 种属内: 同种属相互作用

关联疾病

疾病名称

别名

Amyotrophic Lateral Sclerosis 22 With Or Without Frontotemporal Dementia

ALS22	Amyotrophic Lateral Sclerosis 22, With Or Without Frontotemporal Dementia
Amyotrophic Lateral Sclerosis 22 Without Frontotemporal Dementia

Amyotrophic Lateral Sclerosis Type 22

Als 22	Amyotrohpic Lateral Sclerosis 22 With Or Without Frontotemporal Dementia
Amyotrophic Lateral Sclerosis 22

Joubert Syndrome 8

JBTS8

Joubert Syndrome, Type 8

Spondylometaphyseal Dysplasia, Axial

Axial Spondylometaphyseal Dysplasia	SMDAX
Axial Smd	Smd Axial
Smd, Axial	Spondylometaphyseal Dysplasia Axial Type
Dysplasia, Spondylometaphyseal, Axial

Tinea Favosa

Favus

Myopathy, Myofibrillar, 6

Myofibrillar Myopathy 6	MFM6
Myopathy, Myofibrillar, Bag3-Related	Bag3-Related Myofibrillar Myopathy
Muscular Dystrophy, Selcen Type	Mfm Bag3-Related
Muscular Dystrophy Selcen Type	Myopathy Myofibrillar Bag3-Related

Frontotemporal Dementia

Pallidopontonigral Degeneration	Frontotemporal Lobar Degeneration
Semantic Dementia	FTD
Frontotemporal Lobe Dementia	Multiple System Tauopathy With Presenile Dementia
Dementia, Frontotemporal	Frontotemporal Dementia With Parkinsonism
Mstd	Frontotemporal Lobar Degeneration With Tau Inclusions
Ftld With Tau Inclusions	Dementia, Frontotemporal, With Parkinsonism
Fldem	Ftdp17
Disinhibition-Dementia-Parkinsonism-Amyotrophy Complex	Ddpac
Wilhelmsen-Lynch Disease	Wld
Ppnd	Dementia, Frontotemporal, With Or Without Parkinsonism
Semantic Primary Progressive Aphasia	Semantic Variant Ppa
Wilhemsen-Lynch Disease	Frontotemporal Dementia-Amyotrophic Lateral Sclerosis
Frontotemporal Dementia And Parkinsonism Linked To Chromosome 17	Ftd-Als
Ftld	Pick Complex
Pick Disease Of The Brain	Frontotemporal Dementia With Parkinsonism-17
Grn-Related Frontotemporal Dementia	Frontotemporal Dementia With Motor Neuron Disease
Dementia In Fronto-Temporal Lobar Degeneration	Ftd - [Frontotemporal Dementia]
Temple Dementia	Frontal Lobe Dementia

Lissencephaly

Pachygyria	Broad Gyri Of Cerebrum
Large Gyri Of Cerebrum	Macrogyria

Muscular Dystrophy, Congenital, Due To Integrin Alpha-7 Deficiency

Congenital Muscular Dystrophy Due To Integrin Alpha-7 Deficiency	Muscular Dystrophy, Congenital, Due To Itga7 Deficiency
Congenital Muscular Dystrophy With Integrin Alpha-7 Deficiency	Congenital Muscular Dystrophy With Itga7 Deficiency
Congenital Myopathy Due To Integrin Alpha-7 Deficiency	Myopathy, Congenital, Due To Integrin Alpha-7 Deficiency
Muscular Dystrophy Congenital Due To Integrin Alpha-7 Deficiency	MDCI
Dystrophy, Muscular, Congenital, Due To Integrin Alpha-7 Deficiency

Neuronopathy, Distal Hereditary Motor, Type Iib

HMN2B	Hmn Iib
Neuropathy, Distal Hereditary Motor, Type Iib	Dhmn2b
Distal Hereditary Motor Neuropathy Type 2b	Distal Hereditary Motor Neuropathy Type Iib
Neuronopathy, Distal Hereditary Motor, Type 2b	Neuronopathy, Distal Hereditary Motor, 2b
Dhmn Ii	Neuropathy, Motor, Distal, Hereditary, Type 2b

Charcot-Marie-Tooth Disease, Axonal, Type 2e

Charcot-Marie-Tooth Disease Type 2	CMT2E
CMT2S	CMT2Y
Charcot-Marie-Tooth Disease Type 2e	Charcot-Marie-Tooth Disease Type 2y
Charcot-Marie-Tooth Disease Axonal Type 2s	Charcot-Marie-Tooth Disease, Axonal, Type 2s
Charcot-Marie-Tooth Disease, Type 2e	Hereditary Motor And Sensory Neuropathy Type 2
Charcot-Marie-Tooth Neuropathy, Type 2s	Charcot-Marie-Tooth Disease, Axonal, Autosomal Recessive, Type 2s
Charcot-Marie-Tooth Disease, Axonal, Type 2y	Charcot-Marie-Tooth Disease, Axonal, Autosomal Dominant, Type 2y
Charcot-Marie-Tooth Neuropathy, Type 2y	Charcot-Marie-Tooth Disease, Type 2y
Autosomal Dominant Charcot-Marie-Tooth Disease Type 2e	Charcot-Marie-Tooth Neuropathy Type 2e
Autosomal Dominant Charcot-Marie-Tooth Disease Type 2 Due To Vcp Mutation	Cmt2 Due To Vcp Mutation
Charcot-Marie-Tooth Disease Type 2s	Autosomal Dominant Charcot-Marie-Tooth Disease Type 2
Autosomal Dominant Axonal Charcot-Marie-Tooth Disease	Cmt2
Charcot-Marie-Tooth Neuropathy, Type 2e	Hereditary Motor And Sensory Neuropathy Guadalajara Neuronal Type
Hereditary Motor And Sensory Neuropathy Okinawa Type	Autosomal Dominant Axonal Charcot-Marie-Tooth Type 2y
Charcot-Marie-Tooth Neuropathy Type 2y	Autosomal Recessive Axonal Charcot-Marie-Tooth Type 2s
Charcot-Marie-Tooth Neuropathy Type 2s	Charcot-Marie-Tooth Type 2
Autosomal Dominant Charcot-Marie-Tooth Disease Type 2y	Charcot-Marie-Tooth Disease 2e
Charcot-Marie-Tooth Disease Axonal Type 2e	Charcot-Marie-Tooth Disease Neuronal Type 2e
Charcot-Marie-Tooth Disease 2s	Charcot-Marie-Tooth Neuropathy Axonal Type 2s
Charcot-Marie-Tooth Disease 2y	Charcot-Marie-Tooth Disease, Type 2
Hereditary Motor And Sensory-Neuropathy Type Ii

Frontotemporal Dementia And/Or Amyotrophic Lateral Sclerosis 1

FTDALS1	Frontotemporal Dementia And/Or Motor Neuron Disease
Ftdmnd	Amyotrophic Lateral Sclerosis And/Or Frontotemporal Dementia
Alsftd	Frontotemporal Dementia And/Or Amyotrophic Lateral Sclerosis
Frontotemporal Dementia And/Or Amyotrophic Lateral Sclerosis-1	Frontotemporal Dementia With Motor Neuron Disease
Ftdals	Ftd-Als
Ftd-Mnd	Frontotemporal Dementia With Amyotrophic Lateral Sclerosis
Amyotrophic Lateral Sclerosis With Frontotemporal Dementia 1	Amyotrophic Lateral Sclerosis/Frontotemporal Dementia
Dementia, Frontotemporal, And/Or Amyotrophic Lateral Sclerosis	Amyotrophic Lateral Sclerosis And/Or Frontotemporal Dementia 1
Frontotemporal Lobar Degeneration	Grn-Related Frontotemporal Dementia

Amyotrophic Lateral Sclerosis 1

Amyotrophic Lateral Sclerosis	ALS
Lou Gehrig Disease	Amyotrophic Lateral Sclerosis Type 1
Charcot Disease	ALS1
Amyotrophic Lateral Sclerosis, Susceptibility To	Fals
Lou Gehrig'S Disease	Mnd
Motor Neuron Disease	Familial Amyotrophic Lateral Sclerosis
Amyotrophic Lateral Sclerosis 1, Familial	Amyotrophic Lateral Sclerosis 1, Autosomal Dominant
Motor Neuron Disease, Bulbar	Motor Neurone Disease
Amyotrophic Lateral Sclerosis With Dementia	Dementia With Amyotrophic Lateral Sclerosis
Motor Neuron Disease, Amyotrophic Lateral Sclerosis	Sclerosis, Lateral, Amyotrophic
Sclerosis, Lateral, Amyotrophic, Type 1	Amyotrophic Sclerosis
Als - [Amyotrophic Lateral Sclerosis]	Wasting Palsy
Amyotrophic Paralysis	Amyotrophy Lateral Sclerosis
Wasting Paralysis	Spinal Progressive Amyotrophy
Progressive Atrophic Paralysis

Hereditary Spastic Paraplegia

Familial Spastic Paraplegia	Hereditary Spastic Paraparesis
Strumpell-Lorrain Disease	Familial Spastic Paraparesis
Hsp	Spg
Strümpell-Lorrain Disease	Spastic Paraplegia, Hereditary
French Settlement Disease	Strumpell-Lorrain Syndrome
Fsp	Spastic Paraplegia, Familial
Spastic Paraplegia Hereditary	Spastic Paraplegia 3, Autosomal Dominant
Spastic Paraparesis	Hereditary Spastic Paralysis
Familial Spastic Paralysis	Hereditary Spastic Ataxia

疾病名称	别名
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Cat. No.	产品名	作用方式	纯度	是否罕见病
HY-RS15248	TUBA4A Human Pre-designed siRNA Set A	Pre-designed Sets	/	否

直系同源

种属	基因名	来源	基因 ID
Mus musculus	TUBA4A	MGD	MGI:1095410
Macaca mulatta	TUBA4A	VGNC	VGNC:78673
Rattus norvegicus	TUBA4A	RGD	RGD:1359623
Bos taurus	TUBA4A	VGNC	VGNC:49986
Canis familiaris	TUBA4A	VGNC	VGNC:55011
Felis catus	TUBA4A	VGNC	VGNC:80395

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MedChemExpress (MCE) 只为有资质的科研机构、医药企业基于科学研究或药证申报的用途提供医药研发服务，不为任何个人或者非科研性质的、非用于药证申报使用等其他用途提供服务。

站点地图隐私声明

沪ICP备15051369号-4

上海工商

沪公网安备31011502019417

沪(浦)应急管危经许[2021]201709(QFYS)

营业执照（三证合一）

TUBA4A - tubulin alpha 4a Gene

关于 TUBA4A

功能概要

TUBA4A 基因产物(2)

TUBA4A 蛋白结构

TUBA4A 蛋白互作信息

关联疾病

直系同源

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TUBA4A - tubulin alpha 4a Gene

关于 TUBA4A

功能概要

TUBA4A 基因产物(2)

TUBA4A 蛋白结构

TUBA4A 蛋白互作信息

关联疾病

相关产品

直系同源

热门区域

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C

F

G

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Q

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