2. Gene
  3. CLIP1 - CAP-Gly domain containing linker protein 1 Gene

CLIP1 - CAP-Gly domain containing linker protein 1 Gene

  • 基因
  • 蛋白
  • 疾病
  • 相关产品
  • 直系同源

中文名称：含 CAP-Gly 结构域的接头蛋白 1

种属: Homo sapiens

同用名: RSN; CLIP; CYLN1; CLIP170; CLIP-170

基因 ID: 6249 | 基因类型: protein coding

关于 CLIP1

Cytogenetic location: 12q24.31 Genomic coordinates (GRCh38): 12:122,271,469-122,422,956 (from NCBI)

This gene has 20 transcripts (splice variants), 318 orthologues, 4 paralogues and is associated with 79 phenotypes. Ubiquitous expression in thyroid (RPKM 36.8), esophagus (RPKM 33.7) and 25 other tissues.

功能概要

由该基因编码的蛋白质将内吞囊泡与微管连接起来。该基因在霍奇金病的 Reed-Sternberg 细胞中高度表达。已发现该基因编码不同亚型的几种转录变体。[RefSeq 提供，2011 年 10 月]

The protein encoded by this gene links endocytic vesicles to microtubules. This gene is highly expressed in Reed-Sternberg cells of Hodgkin disease. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2011]

CLIP1 基因产物(4)

mRNA Protein Name
NM_001247997.2 NP_001234926.1 CAP-Gly domain-containing linker protein 1 isoform c
NM_001389291.1 NP_001376220.1 CAP-Gly domain-containing linker protein 1 isoform d
NM_002956.3 NP_002947.1 CAP-Gly domain-containing linker protein 1 isoform a
NM_198240.3 NP_937883.1 CAP-Gly domain-containing linker protein 1 isoform b
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables identical protein binding IPI
IPI: 通过物理相互作用推断
17828275 GOA
enables microtubule binding IDA
IDA: 通过直接分析推断
17889670 GOA
enables microtubule plus-end binding IDA
IDA: 通过直接分析推断
12433698 GOA
enables protein binding IPI
IPI: 通过物理相互作用推断
11940666 GOA
enables tubulin binding IDA
IDA: 通过直接分析推断
17889670 GOA
enables zinc ion binding IDA
IDA: 通过直接分析推断
17828275 GOA
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in microtubule bundle formation IMP
IMP: 通过突变表型推断
17889670 GOA
involved in positive regulation of microtubule polymerization IMP
IMP: 通过突变表型推断
15262990 GOA
细胞组分 GO 注释 逻辑证据 参考文献 来源
located in centrosome IDA
IDA: 通过直接分析推断
21399614 GOA
colocalizes with macropinosome IDA
IDA: 通过直接分析推断
12433698 GOA
located in microtubule IMP
IMP: 通过突变表型推断
19004523 GOA
located in microtubule cytoskeleton IMP
IMP: 通过突变表型推断
17889670 GOA
colocalizes with microtubule plus-end IDA
IDA: 通过直接分析推断
12433698 GOA
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

CLIP1 蛋白结构

CAP_GLY

CAP_GLY: CAP-Gly domain (60 - 124)

CAP_GLY

CAP_GLY: CAP-Gly domain (214 - 278)

  • 0
  • 300
  • 600
  • 900
  • 1200
  • 1438 a.a.
蛋白主名 其他名称

CAP-Gly domain-containing linker protein 1

cytoplasmic linker protein 1

CLIP1 蛋白互作信息

分类
蛋白名称 蛋白编号 互作蛋白 互作蛋白种属 互作蛋白编号 实验方法 参考文献
种属内
CLIP1 P30622 MAPRE1 Homo sapiens Q15691
Chromatography
16455083
种属内
CLIP1 P30622 REL Homo sapiens Q04864-2
Validated Y2H
32296183
种属内
CLIP1 P30622 REL Homo sapiens Q04864-2
Y2H Array
32296183
种属内
CLIP1 P30622 REL Homo sapiens Q04864-2
Y2H Prey Pooling
32296183
种属内
CLIP1 P30622 TUBA4A Homo sapiens P68366
Pull Down
16455083
种属间: 跨种属相互作用 种属内: 同种属相互作用

CLIP1 抗体

目录号 产品名 应用 反应物种
HY-P83065 CLIP170 Antibody (YA2810) WB, IHC-F, IHC-P, ICC/IF, IP Human

关联疾病

疾病名称 别名
Autosomal Recessive Non-Syndromic Intellectual Disability

Ar-Nsid

Ns-Arid
Perry Syndrome

Parkinsonism With Alveolar Hypoventilation And Mental Depression

PERRYS
Neuronopathy, Distal Hereditary Motor, Type Viib

HMN7B

Hmn Viib

Dhmn7b

Neuropathy, Distal Hereditary Motor, Type Viib

Distal Hereditary Motor Neuronopathy Type 7b

Distal Hereditary Motor Neuropathy Type Viib

Neuronopathy, Distal Hereditary Motor, Type 7b

Neuropathy, Distal Hereditary Motor, With Vocal Cord Paralysis, Type Viib

Lower Motor Neuron Disease, Dynactin Type

Distal Spinal Muscular Atrophy With Vocal Cord Paralysis Type 7b

Harper-Young Myopathy

Neuronopathy, Distal Hereditary Motor, 7b

Distal Hereditary Motor Neuropathy With Vocal Cord Paralysis Type Viib

Lower Motor Neuron Disease Dynactin Type

Plmnd

Progressive Lower Motor Neuron Disease

Neuropathy, Motor, Distal, Hereditary, Type Viib
Distal Hereditary Motor Neuronopathy Type 7

Dhmn7

Dhmnvpy

Distal Spinal Muscular Atrophy With Vocal Cord Paralysis
Lissencephaly

Pachygyria

Broad Gyri Of Cerebrum

Large Gyri Of Cerebrum

Macrogyria
Alacrima, Achalasia, And Mental Retardation Syndrome

AAMR

Alacrima, Achalasia, And Intellectual Disability Syndrome

Alacrima, Achalasia, And Impaired Intellectual Development Syndrome

Intellectual Disability
Lissencephaly 1

LIS1

Classic Lissencephaly

Ils

Subcortical Laminar Heterotopia

Lissencephaly Due To Lis1 Mutation

Lissencephaly Sequence, Isolated

Lissencephaly, Classic

Pafah1b1-Related Lissencephaly

Classical Lissencephaly

Lissencephaly Type 1

Lissencephaly-1

Subcortical Band Heterotopia

Double Cortex

Lissencephaly Classic

Lissencephaly Sequence Isolated

Isolated Lissencephaly Sequence

Type 1 Lissencephaly

Lissencephaly Syndrome Type 1

SBH

Sclh

Lissencephaly, Type 1

Type I Lissencephaly
Congenital Nervous System Abnormality

Congenital Neurologic Anomaly

Congenital Nervous System Disorder
疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

相关产品

Pre-clinical Phase
生物活性分子 (1)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-RS02810 CLIP1 Human Pre-designed siRNA Set A Pre-designed Sets / 否

直系同源

种属 基因名 来源 基因 ID
Rattus norvegicus CLIP1 RGD RGD:67404
Canis familiaris CLIP1 VGNC VGNC:39343
Felis catus CLIP1 VGNC VGNC:60961
Bos taurus CLIP1 VGNC VGNC:27444
Macaca mulatta CLIP1 VGNC VGNC:71166
Mus musculus CLIP1 MGD MGI:1928401
Others CLIP1 NCBI
嗨！很高兴为您提供帮助！

尊敬的 MCE 客户您好，
请您选择所在区域，我们将转接对应客服为您服务！

热门区域

A

B

C

F

G

H

J

L

N

Q

S

T

X

Y

Z

热 A B C F G H J L N Q S T X Y Z