C8A - complement C8 alpha chain Gene

中文名称：补充 C8 α 链

种属: Homo sapiens

基因 ID: 731 | 基因类型: protein coding

关于 C8A

Cytogenetic location: 1p32.2 Genomic coordinates (GRCh38): 1:56,854,797-56,918,223 (from NCBI)

This gene has 15 transcripts (splice variants), 188 orthologues, 39 paralogues and is associated with 2 phenotypes. Restricted expression toward liver (RPKM 74.5).

功能概要

C8 是补体系统的一个组成部分，包含三种多肽：α、β 和γ。该基因编码 C8 的 α 亚基。 C8 参与膜攻击复合体 (MAC) 的形成。 MAC 在细菌膜上组装形成一个孔，从而破坏细菌膜组织。该基因的突变会导致补体 C8 α-γ 缺陷。[RefSeq 提供，2008 年 11 月]

C8 is a component of the Complement System and contains three polypeptides, alpha, beta and gamma. This gene encodes the alpha subunit of C8. C8 participates in the formation of the membrane attack complex (MAC). The MAC assembles on Bacterial membranes to form a pore, permitting disruption of Bacterial membrane organization. Mutations in this gene cause complement C8 alpha-gamma deficiency. [provided by RefSeq, Nov 2008]

C8A 基因产物(1)

mRNA	Protein	Name
NM_000562.3	NP_000553.1	complement component C8 alpha chain preproprotein

基因本体论

分子功能
生物过程
细胞组分

分子功能 GO 注释	逻辑证据	参考文献	来源
enables protein binding	IPI IPI: 通过物理相互作用推断	32296183	GOA

生物过程 GO 注释	逻辑证据	参考文献	来源
acts upstream of or within complement activation	IDA IDA: 通过直接分析推断	12413696	GOA

细胞组分 GO 注释	逻辑证据	参考文献	来源
part of membrane attack complex	IDA IDA: 通过直接分析推断	12413696	GOA
part of membrane attack complex	IPI IPI: 通过物理相互作用推断	30552328	GOA

EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

C8A 蛋白结构

Ldl_recept_a

MACPF

TSP_1

0
100
200
300
400
500
584 a.a.

蛋白主名

其他名称

complement component C8 alpha chain

complement component 8 alpha subunit

C8A 蛋白互作信息

分类	蛋白名称	蛋白编号	互作蛋白	互作蛋白种属	互作蛋白编号	实验方法	参考文献
种属内	C8A	P07357	GPR152	Homo sapiens	Q8TDT2	Y2H Array	32296183
种属内	C8A	P07357	GPR152	Homo sapiens	Q8TDT2	Validated Y2H	32296183
种属内	C8A	P07357	GPR152	Homo sapiens	Q8TDT2	Y2H Prey Pooling	32296183
种属内	C8A	P07357	GOLT1A	Homo sapiens	Q6ZVE7	Y2H Array	32296183
种属内	C8A	P07357	GOLT1A	Homo sapiens	Q6ZVE7	Y2H Prey Pooling	32296183
种属内	C8A	P07357	GOLT1A	Homo sapiens	Q6ZVE7	Validated Y2H	32296183
种属内	C8A	P07357	SLC10A1	Homo sapiens	Q14973	Validated Y2H	32296183
种属内	C8A	P07357	SLC10A1	Homo sapiens	Q14973	Y2H Array	32296183
种属内	C8A	P07357	SLC10A1	Homo sapiens	Q14973	Y2H Prey Pooling	32296183
种属内	C8A	P07357	SLC7A1	Homo sapiens	P30825	Y2H Prey Pooling	32296183
种属内	C8A	P07357	SLC7A1	Homo sapiens	P30825	Validated Y2H	32296183
种属内	C8A	P07357	SLC7A1	Homo sapiens	P30825	Y2H Array	32296183
种属内	C8A	P07357	MMGT1	Homo sapiens	Q8N4V1	Y2H Array	32296183
种属内	C8A	P07357	MMGT1	Homo sapiens	Q8N4V1	Validated Y2H	32296183
种属内	C8A	P07357	MMGT1	Homo sapiens	Q8N4V1	Y2H Prey Pooling	32296183

种属间: 跨种属相互作用 种属内: 同种属相互作用

关联疾病

疾病名称

别名

Complement Component 8 Deficiency, Type I

C8 Alpha-Gamma Deficiency	Type I Complement Component 8 Deficiency
C8D1	C8 Deficiency Type I
Complement Component 8 Deficiency Type I	C8 Deficiency, Type I
C8ag Deficiency	Complement Component 8 Deficiency Type 1
C81 Deficiency	Complement Component 8 Deficiency, 1
Complement Component 8 Deficiency, Type 1

Immunodeficiency Due To A Late Component Of Complement Deficiency

Immunodeficiency Due To C5 To C9 Component Complement Deficiency

Terminal Complement Pathway Deficiency

Complement Component 8 Deficiency

C8 Deficiency

Bartter Syndrome, Type 4a, Neonatal, With Sensorineural Deafness

Bsnd	Sensorineural Deafness With Mild Renal Dysfunction
Bartter Disease Type 4a	BARTS4A
Bartter Syndrome, Type 4a	Bartter Syndrome Type 4
Bartter Syndrome, Neonatal, With Sensorineural Deafness	Bartter Syndrome With Sensorineural Deafness
Bartter Syndrome Type 4a	Neonatal Bartter Syndrome With Sensorineural Deafness
Bartter Syndrome Type Iv	Bartter Syndrome With Sensorineural Hearing Loss
Bartter Syndrome 4a, Neonatal, With Sensorineural Deafness	Hyperprostanglandin E Syndrome 4
Hypokalemic Alkalosis With Hypercalciuria Antenatal 4	Infantile Bartter Syndrome With Sensorineural Deafness

Hemolytic Uremic Syndrome, Atypical 1

Atypical Hemolytic-Uremic Syndrome	Hemolytic Uremic Syndrome, Atypical, Susceptibility To, 1
Atypical Hemolytic Uremic Syndrome	Hemolytic Uremic Syndrome, Atypical, Susceptibility To
Ahus	AHUS1
Hemolytic-Uremic Syndrome	Ahus 1
Ahus, Susceptibility To, 1	Hemolytic Uremic Syndrome, Atypical
Non-Shiga-Like Toxin-Associated Hus	Non-Stx-Hus
Nonenteropathic Hus	Atypical Hus
Shiga Toxin-Associated Hemolytic Uremic Syndrome	D+ Hus
Ehec-Hus	Hemolytic Uremic Syndrome Associated With Shiga Toxin-Producing Escherichia Coli
Hemolytic Uremic Syndrome With Diarrhea	Stec-Hus
Shiga-Like Toxin-Associated Hus	Stx-Hus
Typical Hus	Typical Hemolytic Uremic Syndrome
Atypical Hemolytic Uremic Syndrome With Anti-Factor H Antibodies	Atypical Hus With Anti-Factor H Antibodies
Ahus With Anti-Factor H Antibodies	Ahus With Neutralizing Autoantibodies Against Factor H
Hemolytic Uremic Syndrome Atypical 1	Atypical Hemolytic Uremic Syndrome With H Factor Anomaly
D Hus	Hemolytic-Uremic Syndrome Without Diarrhea
Hemolytic-Uremic Syndrome, Atypical, Type 1	Hemolytic Uremic Syndrome, Typical

疾病名称	别名
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Cat. No.	产品名	作用方式	纯度	是否罕见病
HY-RS01755	C8A Human Pre-designed siRNA Set A	Pre-designed Sets	/	否

直系同源

种属	基因名	来源	基因 ID
Bos taurus	C8A	VGNC	VGNC:26644
Macaca mulatta	C8A	VGNC	VGNC:70479
Mus musculus	C8A	MGD	MGI:2668347
Felis catus	C8A	VGNC	VGNC:60235
Canis familiaris	C8A	VGNC	VGNC:38600
Rattus norvegicus	C8A	RGD	RGD:1308355
Macaca fascicularis	C8A	NCBI	NCBI:102133722
Others	C8A	NCBI

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MedChemExpress (MCE) 只为有资质的科研机构、医药企业基于科学研究或药证申报的用途提供医药研发服务，不为任何个人或者非科研性质的、非用于药证申报使用等其他用途提供服务。

站点地图隐私声明

沪ICP备15051369号-4

上海工商

沪公网安备31011502019417

沪(浦)应急管危经许[2021]201709(QFYS)

营业执照（三证合一）

C8A - complement C8 alpha chain Gene

关于 C8A

功能概要

C8A 基因产物(1)

C8A 蛋白结构

C8A 蛋白互作信息

关联疾病

直系同源

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C8A - complement C8 alpha chain Gene

关于 C8A

功能概要

C8A 基因产物(1)

C8A 蛋白结构

C8A 蛋白互作信息

关联疾病

相关产品

直系同源

热门区域

A

B

C

F

G

H

J

L

N

Q

S

T

X

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