1. Gene
  2. UBE2L3 - ubiquitin conjugating enzyme E2 L3 Gene

UBE2L3 - ubiquitin conjugating enzyme E2 L3 Gene

中文名称:泛素结合酶 E2 L3

种属: Homo sapiens

同用名: E2-F1; L-UBC; UBCH7; UbcM4

基因 ID: 7332 | 基因类型: protein coding

关于 UBE2L3

Cytogenetic location: 22q11.21 Genomic coordinates (GRCh38): 22:21,549,447-21,624,034 (from NCBI)

This gene has 5 transcripts (splice variants), 159 orthologues, 12 paralogues and is associated with 1 phenotype. Ubiquitous expression in brain (RPKM 19.5), urinary bladder (RPKM 19.0) and 25 other tissues.

功能概要

用泛素修饰蛋白质是靶向异常或短寿命蛋白质进行降解的重要细胞机制。泛素化至少涉及三类酶:泛素激活酶 (E1s) 、泛素结合酶 (E2s) 和泛素蛋白连接酶 (E3s) 。该基因编码 E2 泛素结合酶家族的成员。证明该酶在体外参与 p53、c-Fos 和 NF-kB 前体 p105 的泛素化。已发现该基因的几种可变剪接转录物变体。[RefSeq 提供,2009 年 9 月]

The modification of proteins with ubiquitin is an important cellular mechanism for targeting abnormal or short-lived proteins for degradation. Ubiquitination involves at least three classes of enzymes: ubiquitin-activating Enzymes (E1s), ubiquitin-conjugating Enzymes (E2s) and ubiquitin-protein ligases (E3s). This gene encodes a member of the E2 ubiquitin-conjugating Enzyme family. This Enzyme is demonstrated to participate in the ubiquitination of p53, c-Fos, and the NF-kB precursor p105 in vitro. Several alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Sep 2009]

UBE2L3 基因产物(3)

mRNA Protein Name
NM_001256355.1 NP_001243284.1 ubiquitin-conjugating enzyme E2 L3 isoform 4
NM_001256356.2 NP_001243285.1 ubiquitin-conjugating enzyme E2 L3 isoform 3
NM_003347.4 NP_003338.1 ubiquitin-conjugating enzyme E2 L3 isoform 1
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables protein binding IPI
IPI: 通过物理相互作用推断
9990509 GOA
enables transcription coactivator activity IDA
IDA: 通过直接分析推断
15367689 GOA
enables ubiquitin conjugating enzyme activity IDA
IDA: 通过直接分析推断
20061386 GOA
enables ubiquitin protein ligase binding IPI
IPI: 通过物理相互作用推断
11278816 GOA
enables ubiquitin-protein transferase activator activity IGI
IGI: 通过遗传相互作用推断
12628165 GOA
enables ubiquitin-protein transferase activity IDA
IDA: 通过直接分析推断
14765125 GOA
enables ubiquitin-protein transferase activity IMP
IMP: 通过突变表型推断
10888878 GOA
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in cell cycle phase transition IMP
IMP: 通过突变表型推断
18946090 GOA
involved in cell population proliferation IMP
IMP: 通过突变表型推断
18946090 GOA
involved in cellular response to glucocorticoid stimulus IDA
IDA: 通过直接分析推断
17003263 GOA
involved in cellular response to steroid hormone stimulus IMP
IMP: 通过突变表型推断
15367689 GOA
involved in positive regulation of protein ubiquitination IGI
IGI: 通过遗传相互作用推断
12628165 GOA
involved in positive regulation of ubiquitin-protein transferase activity IGI
IGI: 通过遗传相互作用推断
12628165 GOA
involved in protein K11-linked ubiquitination IDA
IDA: 通过直接分析推断
20061386 GOA
involved in protein polyubiquitination IDA
IDA: 通过直接分析推断
10888878 GOA
involved in protein ubiquitination IDA
IDA: 通过直接分析推断
9990509 GOA
involved in regulation of DNA-templated transcription IDA
IDA: 通过直接分析推断
17003263 GOA
involved in regulation of DNA-templated transcription IMP
IMP: 通过突变表型推断
15367689 GOA
细胞组分 GO 注释 逻辑证据 参考文献 来源
located in cytoplasm IDA
IDA: 通过直接分析推断
9990509 GOA
located in nucleus IDA
IDA: 通过直接分析推断
11278816 GOA
EXP:通过实验结果推断 IDA:通过直接分析推断 IPI:通过物理相互作用推断 IMP:通过突变表型推断 IGI:通过遗传相互作用推断 IEP:通过表达模式推断

UBE2L3 蛋白结构

UQ_con

UQ_con: Ubiquitin-conjugating enzyme (6 - 142)

  • 0
  • 100
  • 154 a.a.
蛋白主名 其他名称

ubiquitin-conjugating enzyme E2 L3

E2 ubiquitin-conjugating enzyme L3

UBE2L3 蛋白互作信息

分类
蛋白名称 蛋白编号 互作蛋白 互作蛋白种属 互作蛋白编号 实验方法 参考文献
种属内
UBE2L3 P68036 RNF182 Homo sapiens Q8N6D2
Y2H Prey Pooling
32296183
种属内
UBE2L3 P68036 RNF182 Homo sapiens Q8N6D2
Validated Y2H
32296183
种属内
UBE2L3 P68036 RNF182 Homo sapiens Q8N6D2
Y2H Array
32296183
种属内
UBE2L3 P68036 MID1 Homo sapiens O15344
Y2H Prey Pooling
32296183
种属内
UBE2L3 P68036 MID1 Homo sapiens O15344
Y2H Array
32296183
种属内
UBE2L3 P68036 RBCK1 Homo sapiens Q9BYM8
Y2H Array
19549727
种属内
UBE2L3 P68036 RBCK1 Homo sapiens Q9BYM8
Y2H Prey Pooling
32296183
种属内
UBE2L3 P68036 RBCK1 Homo sapiens Q9BYM8
Validated Y2H
32296183
种属内
UBE2L3 P68036 RBCK1 Homo sapiens Q9BYM8
Y2H Array
32296183
种属内
UBE2L3 P68036 RNF144A Homo sapiens P50876
Y2H Prey Pooling
32296183
种属内
UBE2L3 P68036 RNF144A Homo sapiens P50876
Y2H Array
32296183
种属内
UBE2L3 P68036 RNF19B Homo sapiens Q6ZMZ0
Anti Bait CoIP
16709802
种属内
UBE2L3 P68036 ARIH2 Homo sapiens O95376
Anti Tag CoIP
33961781
种属内
UBE2L3 P68036 RNF216 Homo sapiens Q9NWF9
Y2H Prey Pooling
32296183
种属内
UBE2L3 P68036 RNF216 Homo sapiens Q9NWF9
Validated Y2H
32296183
种属内
UBE2L3 P68036 RNF216 Homo sapiens Q9NWF9
Y2H Array
32296183
种属间: 跨种属相互作用 种属内: 同种属相互作用

重组 UBE2L3 蛋白

目录号 产品名 蛋白编号 纯度
HY-P79451 UbcH7/UBE2L3 Protein, Human P68036-1 (M1-D154) ≥95%

关联疾病

疾病名称 别名
Papilloma

Papillomatosis

Systemic Lupus Erythematosus

Lupus Nephritis

SLE

Disseminated Lupus Erythematosus

Systemic Lupus Erythematosus, Susceptibility To

Lupus Erythematosus, Systemic

Lupus Nephritis, Susceptibility To

Libman-Sacks Disease

Systemic Lupus Erythematosus Susceptibility To

Sle - Lupus Erythematosus, Systemic

Le Syndrome

Lupus

Lupus Erythematosus Systemic

Lupus Erythematosus, Systemic, Susceptibility To

Lupus Vulgaris

Lupus Erythematosus, Discoid

Lupus Erythematosus

Systemic Lupus Erythematosus Nos

Sle - [Systemic Lupus Erythematosus]

Machado-Joseph Disease

SCA3

MJD

Spinocerebellar Ataxia 3

Azorean Disease

Spinocerebellar Ataxia Type 3

Spinocerebellar Atrophy

Azorean Neurologic Disease

Spinopontine Atrophy

Nigrospinodentatal Degeneration

Spinocerebellar Atrophy Iii

Spinocerebellar Atrophy Type 3

Azorean Ataxia

Azorean Disease Of The Nervous System

Machado Disease

Nigro-Spino-Dentatal Degeneration With Nuclear Ophthalmoplegia

Disease, Machado-Joseph

Ataxia, Spinocerebellar

Angelman Syndrome

AS

Happy Puppet Syndrome

Happy Puppet Syndrome, Formerly

Puppetlike Syndrome

Glycogen Storage Disease Iv

Gsd Iv

Glycogen Branching Enzyme Deficiency

Andersen Disease

Amylopectinosis

Glycogen Storage Disease Type Iv

GSD4

Brancher Deficiency

Glycogen Storage Disease, Type Iv

Glycogen Storage Disease Due To Glycogen Branching Enzyme Deficiency, Congenital Neuromuscular Form

Gbe1 Deficiency

Glycogenosis Iv

Cirrhosis, Familial, With Deposition Of Abnormal Glycogen

Glycogen Storage Disease Type 4

Glycogenosis 4

Potassium-Sensitive Periodic Paralysis, Ventricular Ectopy, And Dysmorphic Features

Andersen'S Disease

Glycogen Storage Disease Due To Glycogen Branching Enzyme Deficiency, Childhood Neuromuscular Form

Glycogen Storage Disease Due To Glycogen Branching Enzyme Deficiency, Fatal Perinatal Neuromuscular Form

Brancher Deficiency Glycogenosis

Branching-Transferase Deficiency Glycogenosis

Deficiency Of 1,4-Alpha-Glucan Branching Enzyme

Andersen-Tawil Syndrome

Gsd 4

Andersen Cardiodysrhythmic Periodic Paralysis

Lqt7

Long Qt Syndrome 7

Periodic Paralysis, Potassium-Sensitive Cardiodysrhythmic Type

Andersen Glycogenosis

Branching Enzyme Deficiency

Glycogenosis, Type Iv

Gsd Type Iv

Type Iv Glycogenosis

Gbe Deficiency, Childhood Neuromuscular Form

Gsd Due To Glycogen Branching Enzyme Deficiency, Childhood Neuromuscular Form

Gsd Type 4, Childhood Neuromuscular Form

Gsdiv, Childhood Neuromuscular Form

Glycogen Storage Disease Type 4, Childhood Neuromuscular Form

Glycogen Storage Disease Type Iv, Childhood Neuromuscular Form

Glycogenosis Due To Glycogen Branching Enzyme Deficiency, Childhood Neuromuscular Form

Glycogenosis Type 4, Childhood Neuromuscular Form

Glycogenosis Type Iv, Childhood Neuromuscular Form

Glycogen Storage Disease Due To Glycogen Branching Enzyme Deficiency, Adult Neuromuscular Form

Gbe Deficiency, Adult Neuromuscular Form

Gsd Due To Glycogen Branching Enzyme Deficiency, Adult Neuromuscular Form

Gsd Type 4, Adult Neuromuscular Form

Gsdiv, Adult Neuromuscular Form

Glycogen Storage Disease Type 4, Adult Neuromuscular Form

Glycogen Storage Disease Type Iv, Adult Neuromuscular Form

Glycogenosis Due To Glycogen Branching Enzyme Deficiency, Adult Neuromuscular Form

Glycogenosis Type 4, Adult Neuromuscular Form

Glycogenosis Type Iv, Adult Neuromuscular Form

Gbe Deficiency, Congenital Neuromuscular Form

Gsd Due To Glycogen Branching Enzyme Deficiency, Congenital Neuromuscular Form

Gsd Type 4, Congenital Neuromuscular Form

Gsdiv, Congenital Neuromuscular Form

Glycogen Storage Disease Type 4, Congenital Neuromuscular Form

Glycogen Storage Disease Type Iv, Congenital Neuromuscular Form

Glycogenosis Due To Glycogen Branching Enzyme Deficiency, Congenital Neuromuscular Form

Glycogenosis Type 4, Congenital Neuromuscular Form

Glycogenosis Type Iv, Congenital Neuromuscular Form

Glycogen Storage Disease Due To Glycogen Branching Enzyme Deficiency, Childhood Combined Hepatic And Myopathic Form

Gbe Deficiency, Childhood Combined Hepatic And Myopathic Form

Gsd Due To Glycogen Branching Enzyme Deficiency, Childhood Combined Hepatic And Myopathic Form

Gsd Type 4, Childhood Combined Hepatic And Myopathic Form

Gsdiv, Childhood Combined Hepatic And Myopathic Form

Glycogen Storage Disease Type 4, Childhood Combined Hepatic And Myopathic Form

Glycogen Storage Disease Type Iv, Childhood Combined Hepatic And Myopathic Form

Glycogenosis Due To Glycogen Branching Enzyme Deficiency, Childhood Combined Hepatic And Myopathic Form

Glycogenosis Type 4, Childhood Combined Hepatic And Myopathic Form

Glycogenosis Type Iv, Childhood Combined Hepatic And Myopathic Form

Gbe Deficiency, Fatal Perinatal Neuromuscular Form

Gsd Due To Glycogen Branching Enzyme Deficiency, Fatal Perinatal Neuromuscular Form

Gsd Type 4, Fatal Perinatal Neuromuscular Form

Gsdiv, Fatal Perinatal Neuromuscular Form

Glycogen Storage Disease Type 4, Fatal Perinatal Neuromuscular Form

Glycogen Storage Disease Type Iv, Fatal Perinatal Neuromuscular Form

Glycogenosis Due To Glycogen Branching Enzyme Deficiency, Fatal Perinatal Neuromuscular Form

Glycogenosis Type 4, Fatal Perinatal Neuromuscular Form

Glycogenosis Type Iv, Fatal Perinatal Neuromuscular Form

Glycogen Storage Disease Due To Glycogen Branching Enzyme Deficiency, Non Progressive Hepatic Form

Gbe Deficiency, Non Progressive Hepatic Form

Gsd Due To Glycogen Branching Enzyme Deficiency, Non Progressive Hepatic Form

Gsd Type 4, Non Progressive Hepatic Form

Gsdiv, Non Progressive Hepatic Form

Glycogen Storage Disease Type 4, Non Progressive Hepatic Form

Glycogen Storage Disease Type Iv, Non Progressive Hepatic Form

Glycogenosis Due To Glycogen Branching Enzyme Deficiency, Non Progressive Hepatic Form

Glycogenosis Type 4, Non Progressive Hepatic Form

Glycogenosis Type Iv, Non Progressive Hepatic Form

Glycogen Storage Disease Due To Glycogen Branching Enzyme Deficiency, Progressive Hepatic Form

Gbe Deficiency, Progressive Hepatic Form

Gsd Due To Glycogen Branching Enzyme Deficiency, Progressive Hepatic Form

Gsd Type 4, Progressive Hepatic Form

Gsdiv, Progressive Hepatic Form

Glycogen Storage Disease Type 4, Progressive Hepatic Form

Glycogen Storage Disease Type Iv, Progressive Hepatic Form

Glycogenosis Due To Glycogen Branching Enzyme Deficiency, Progressive Hepatic Form

Glycogenosis Type 4, Progressive Hepatic Form

Glycogenosis Type Iv, Progressive Hepatic Form

Glycogen Storage Disease 4

Gsd-Iv

Storage Disease, Glycogen, Type Iv

Parkinson Disease, Late-Onset

Parkinson Disease

Parkinson'S Disease

PD

PARK

Parkinson Disease, Susceptibility To

Late Onset Parkinson'S Disease

Late Onset Parkinson Disease

Paralysis Agitans

Primary Parkinsonism

Idiopathic Parkinson Disease

Parkinson'S

Parkinson Disease, Late-Onset, Susceptibility To

Parkinson Disease, Age Of Onset, Modifier

Lewy Body Parkinson Disease

Idiopathic Parkinson'S Disease

Pd - [Parkinson Disease]

Parkinson Disease Nos

Parkinson, Nos

Primary Parkinson Disease

Celiac Disease 1

Celiac Disease

Coeliac Disease

Celiac Sprue

Celiac Disease, Susceptibility To

Gluten-Sensitive Enteropathy

Nontropical Sprue

Sprue

CELIAC1

Celiac Disease, Susceptibility To, 1

Celiac Sprue 1

Celiac Sprue, Susceptibility To, 1

Gluten-Sensitive Enteropathy 1

Gluten-Sensitive Enteropathy, Susceptibility To, 1

Idiopathic Steatorrhea

Cœliac Disease

Gluten Intolerance

Gluten-Induced Enteropathy

Gluten Enteropathy

Celiac Disease, Susceptibility To, Type 1

Childhood Celiac Disease

Coeliac Rickets

Gee Disease

Gee-Herter Disease

Heubner-Herter Disease

Idiopathic Steatorrhoea

Thaysen'S Disease

Herter Gee Syndrome

疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

直系同源

种属 基因名 来源 基因 ID
Rattus norvegicus UBE2L3 RGD RGD:1308361
Bos taurus UBE2L3 VGNC VGNC:53927
Mus musculus UBE2L3 MGD MGI:109240
Others UBE2L3 NCBI