1. Gene
  2. UCHL3 - ubiquitin C-terminal hydrolase L3 Gene

UCHL3 - ubiquitin C-terminal hydrolase L3 Gene

中文名称:泛素 C 端水解酶 L3

种属: Homo sapiens

同用名: UCH-L3

基因 ID: 7347 | 基因类型: protein coding

关于 UCHL3

Cytogenetic location: 13q22.2 Genomic coordinates (GRCh38): 13:75,549,502-75,606,020 (from NCBI)

This gene has 6 transcripts (splice variants), 216 orthologues and 3 paralogues. Ubiquitous expression in thyroid (RPKM 5.1), testis (RPKM 4.9) and 25 other tissues.

功能概要

该基因编码的蛋白质是去泛素化酶家族的成员。该家族的成员是催化从多肽中去除泛素的蛋白酶,根据催化机制分为五类。这种蛋白质可以水解泛素化蛋白质的泛素基-N-ε 酰胺键,为另一个催化循环再生泛素。可变剪接导致编码不同蛋白质亚型的多个转录变体。[RefSeq 提供,2012 年 8 月]

The protein encoded by this gene is a member of the deubiquitinating Enzyme family. Members of this family are proteases that catalyze the removal of ubiquitin from polypeptides and are divided into five classes, depending on the mechanism of catalysis. This protein may hydrolyze the ubiquitinyl-N-epsilon amide bond of ubiquitinated proteins to regenerate ubiquitin for another catalytic cycle. Alternative splicing results in multiple transcript variants that encode different protein isoforms. [provided by RefSeq, Aug 2012]

UCHL3 基因产物(2)

mRNA Protein Name
NM_001270952.2 NP_001257881.1 ubiquitin carboxyl-terminal hydrolase isozyme L3 isoform 1
NM_006002.5 NP_005993.1 ubiquitin carboxyl-terminal hydrolase isozyme L3 isoform 2

UCHL3 蛋白结构

Peptidase_C12

Peptidase_C12: Ubiquitin carboxyl-terminal hydrolase, family 1 (5 - 215)

  • 0
  • 100
  • 200
  • 230 a.a.
蛋白主名 其他名称

ubiquitin carboxyl-terminal hydrolase isozyme L3

testicular tissue protein Li 221

重组 UCHL3 蛋白

目录号 产品名 蛋白编号 纯度
HY-P71115 UCHL3 Protein, Human (His) P15374 (M1-A230) ≥95%

关联疾病

疾病名称 别名
Autosomal Dominant Cerebellar Ataxia

Spinocerebellar Ataxia

Adca

Pierre Marie Cerebellar Ataxia

Ataxia, Spinocerebellar

Sca

Autosomal Dominant Spinocerebellar Ataxia

Spinocerebellar Ataxias

疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

直系同源

种属 基因名 来源 基因 ID
Macaca mulatta UCHL3 VGNC VGNC:78706
Bos taurus UCHL3 VGNC VGNC:36632
Rattus norvegicus UCHL3 RGD RGD:1561196
Mus musculus UCHL3 MGD MGI:1355274
Felis catus UCHL3 VGNC VGNC:66796
Canis familiaris UCHL3 VGNC VGNC:48104
Others UCHL3 NCBI