1. Gene
  2. VAV2 - vav guanine nucleotide exchange factor 2 Gene

VAV2 - vav guanine nucleotide exchange factor 2 Gene

中文名称:vav 鸟嘌呤核苷酸交换因子 2

种属: Homo sapiens

同用名: VAV-2

基因 ID: 7410 | 基因类型: protein coding

关于 VAV2

Cytogenetic location: 9q34.2 Genomic coordinates (GRCh38): 9:133,761,894-133,992,324 (from NCBI)

This gene has 5 transcripts (splice variants), 209 orthologues and 22 paralogues. Ubiquitous expression in adrenal (RPKM 10.2), small intestine (RPKM 8.2) and 25 other tissues.

功能概要

VAV2 是癌基因 VAV 鸟嘌呤核苷酸交换因子家族的第二个成员。与仅在造血细胞中表达的 VAV1 不同,VAV2 转录本存在于大多数组织中。已发现该基因编码不同亚型的可变剪接转录物变体。[RefSeq 提供,2008 年 8 月]

VAV2 is the second member of the VAV guanine nucleotide exchange factor family of oncogenes. Unlike VAV1, which is expressed exclusively in hematopoietic cells, VAV2 transcripts were found in most tissues. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Aug 2008]

VAV2 基因产物(3)

mRNA Protein Name
NM_001134398.2 NP_001127870.1 guanine nucleotide exchange factor VAV2 isoform 1
NM_001411028.1 NP_001397957.1 guanine nucleotide exchange factor VAV2 isoform 3
NM_003371.4 NP_003362.2 guanine nucleotide exchange factor VAV2 isoform 2
基因本体论
  • 分子功能
  • 生物过程
分子功能 GO 注释 逻辑证据 参考文献 来源
enables guanyl-nucleotide exchange factor activity EXP
EXP: 通过实验结果推断
8990121 GOA
enables phosphotyrosine residue binding IPI
IPI: 通过物理相互作用推断
20624904 GOA
enables protein binding IPI
IPI: 通过物理相互作用推断
11390470 GOA
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in regulation of GTPase activity IGI
IGI: 通过遗传相互作用推断
22467863 GOA
NOT involved in regulation of cell size IGI
IGI: 通过遗传相互作用推断
22467863 GOA
involved in regulation of cell size IGI
IGI: 通过遗传相互作用推断
22467863 GOA
EXP:通过实验结果推断 IDA:通过直接分析推断 IPI:通过物理相互作用推断 IMP:通过突变表型推断 IGI:通过遗传相互作用推断 IEP:通过表达模式推断

VAV2 蛋白结构

CAMSAP_CH

CAMSAP_CH: CAMSAP CH domain (19 - 103)

RhoGEF

RhoGEF: RhoGEF domain (202 - 375)

PH

PH: PH domain (408 - 511)

C1_1

C1_1: Phorbol esters/diacylglycerol binding domain (C1 domain) (524 - 571)

SH3_2

SH3_2: Variant SH3 domain (591 - 650)

SH2

SH2: SH2 domain (673 - 747)

SH3_2

SH3_2: Variant SH3 domain (826 - 874)

  • 0
  • 200
  • 400
  • 600
  • 800
  • 878 a.a.
蛋白主名 其他名称

guanine nucleotide exchange factor VAV2

vav 2 oncogene

VAV2 蛋白互作信息

分类
蛋白名称 蛋白编号 互作蛋白 互作蛋白种属 互作蛋白编号 实验方法 参考文献
Intra VAV2 P52735 NEK3 Homo sapiens P51956
CoIP
15618286
Intra VAV2 P52735 GAB1 Homo sapiens Q13480
FPS
24728074
Intra VAV2 P52735 CAV1 Homo sapiens Q03135
Anti Bait CoIP
20808760
Intra VAV2 P52735 ERBB2 Homo sapiens P04626
Protein Array
16273093
Intra VAV2 P52735 TOM1L1 Homo sapiens O75674
Anti Tag CoIP
18654987
Intra VAV2 P52735 SH3BP2 Homo sapiens P78314
Pull Down
11390470
Intra VAV2 P52735 SH3BP2 Homo sapiens P78314
Y2H
15345594
Intra VAV2 P52735 SH3BP2 Homo sapiens P78314
Pull Down
15345594
Intra VAV2 P52735 SH3BP2 Homo sapiens P78314
Anti Tag CoIP
15345594
种属间: 跨种属相互作用 种属内: 同种属相互作用

直系同源

种属 基因名 来源 基因 ID
Macaca mulatta VAV2 VGNC VGNC:78758
Felis catus VAV2 VGNC VGNC:66926
Mus musculus VAV2 MGD MGI:102718
Rattus norvegicus VAV2 RGD RGD:1306285
Canis familiaris VAV2 VGNC VGNC:58344
Bos taurus VAV2 VGNC VGNC:36773