2. Gene
  3. TOM1L1 - target of myb1 like 1 membrane trafficking protein Gene

TOM1L1 - target of myb1 like 1 membrane trafficking protein Gene

  • 基因
  • 蛋白
  • 疾病
  • 相关产品
  • 直系同源

中文名称：myb1 的目标样 1 膜运输蛋白

种属: Homo sapiens

同用名: SRCASM

基因 ID: 10040 | 基因类型: protein coding

关于 TOM1L1

Cytogenetic location: 17q22 Genomic coordinates (GRCh38): 17:54,900,852-54,961,956 (from NCBI)

This gene has 23 transcripts (splice variants), 152 orthologues and 10 paralogues. Broad expression in duodenum (RPKM 37.8), thyroid (RPKM 25.7) and 24 other tissues.

功能概要

启用网格蛋白结合活性和蛋白激酶结合活性。参与有丝分裂核分裂的负调控；蛋白质磷酸化的正调节；和信号转导。位于胞质溶胶和核内体中。 [由基因组资源联盟提供，2022 年 4 月]

Enables clathrin binding activity and protein kinase binding activity. Involved in negative regulation of mitotic nuclear division; positive regulation of protein phosphorylation; and signal transduction. Located in cytosol and endosome. [provided by Alliance of Genome Resources, Apr 2022]

TOM1L1 基因产物(5)

mRNA Protein Name
NM_001321173.2 NP_001308102.1 TOM1-like protein 1 isoform 2
NM_001321174.2 NP_001308103.1 TOM1-like protein 1 isoform 3
NM_001321175.2 NP_001308104.1 TOM1-like protein 1 isoform 3
NM_001321176.2 NP_001308105.1 TOM1-like protein 1 isoform 3
NM_005486.3 NP_005477.2 TOM1-like protein 1 isoform 1
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables clathrin binding IDA
IDA: 通过直接分析推断
16412388 GOA
enables protein binding IPI
IPI: 通过物理相互作用推断
15611048 GOA
enables protein kinase binding IPI
IPI: 通过物理相互作用推断
16479011 GOA
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in activation of protein kinase activity IDA
IDA: 通过直接分析推断
16479011 GOA
involved in negative regulation of mitotic nuclear division IDA
IDA: 通过直接分析推断
16479011 GOA
involved in positive regulation of protein autophosphorylation IDA
IDA: 通过直接分析推断
16479011 GOA
NOT involved in regulation of DNA biosynthetic process IDA
IDA: 通过直接分析推断
16479011 GOA
involved in signal transduction IDA
IDA: 通过直接分析推断
16479011 GOA
细胞组分 GO 注释 逻辑证据 参考文献 来源
located in cytoplasm IDA
IDA: 通过直接分析推断
16412388 GOA
located in cytosol IDA
IDA: 通过直接分析推断
15611048 GOA
located in endosome IDA
IDA: 通过直接分析推断
15611048 GOA
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

TOM1L1 蛋白结构

VHS

VHS: VHS domain (12 - 150)

GAT

GAT: GAT domain (199 - 292)

  • 0
  • 100
  • 200
  • 300
  • 400
  • 476 a.a.
蛋白主名 其他名称

TOM1-like protein 1

src-activating and signaling molecule protein

TOM1L1 蛋白互作信息

分类
蛋白名称 蛋白编号 互作蛋白 互作蛋白种属 互作蛋白编号 实验方法 参考文献
种属内
TOM1L1 O75674 EGFR Homo sapiens P00533
Anti Bait CoIP
19798056
种属内
TOM1L1 O75674 VAV2 Homo sapiens P52735
Y2H
18654987
种属内
TOM1L1 O75674 CLTC Homo sapiens Q00610
Pull Down
19798056
种属内
TOM1L1 O75674 GRB2 Homo sapiens P62993
Pull Down
19798056
种属内
TOM1L1 O75674 GRB2 Homo sapiens P62993
Anti Bait CoIP
19798056
种属内
TOM1L1 O75674 TOM1 Homo sapiens O60784
Pull Down
19798056
种属间: 跨种属相互作用 种属内: 同种属相互作用

关联疾病

疾病名称 别名
Nodular Basal Cell Carcinoma

Basal Cell Carcinoma, Nodular

Circumscribed Solid Basal Cell Carcinoma

Skin Nodulo-Ulcerative Basal Cell Carcinoma

Skin Solid Basal Cell Carcinoma

Skin Nodular Basal Cell Carcinoma

Skin Nodular Solid Basal Cell Carcinoma

Nodulo-Ulcerative Basal Cell Carcinoma

Circumscribed Solid Basal Cell Carcinoma Of Skin
疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

相关产品

Pre-clinical Phase
生物活性分子 (1)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-RS14877 TOM1L1 Human Pre-designed siRNA Set A Pre-designed Sets / 否

直系同源

种属 基因名 来源 基因 ID
Bos taurus TOM1L1 VGNC VGNC:36218
Canis familiaris TOM1L1 VGNC VGNC:47708
Rattus norvegicus TOM1L1 RGD RGD:1562626
Mus musculus TOM1L1 MGD MGI:1919193
Felis catus TOM1L1 VGNC VGNC:97667
Macaca mulatta TOM1L1 VGNC VGNC:78616
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