VDAC2 - voltage dependent anion channel 2 Gene

中文名称：电压依赖性阴离子通道 2

种属: Homo sapiens

同用名: POR

基因 ID: 7417 | 基因类型: protein coding

关于 VDAC2

Cytogenetic location: 10q22.2 Genomic coordinates (GRCh38): 10:75,210,170-75,231,448 (from NCBI)

This gene has 14 transcripts (splice variants), 237 orthologues and 2 paralogues. Ubiquitous expression in heart (RPKM 81.3), esophagus (RPKM 66.2) and 25 other tissues.

功能概要

该基因编码电压依赖性阴离子通道成孔蛋白家族的成员，这些蛋白被认为是代谢物扩散穿过线粒体外膜的主要途径。编码的蛋白质也被认为通过调节 BCL2 拮抗剂/杀手 1 蛋白活性参与线粒体凋亡途径。已在 1、2、12 和 21 号染色体上鉴定出假基因，可变剪接导致多个转录本变体。[RefSeq 提供，2010 年 5 月]

This gene encodes a member of the voltage-dependent anion channel pore-forming family of proteins that are considered the main pathway for metabolite diffusion across the mitochondrial outer membrane. The encoded protein is also thought to be involved in the mitochondrial apoptotic pathway via regulation of BCL2-antagonist/killer 1 protein activity. Pseudogenes have been identified on chromosomes 1, 2, 12 and 21, and alternative splicing results in multiple transcript variants. [provided by RefSeq, May 2010]

VDAC2 基因产物(8)

mRNA	Protein	Name
NM_001184783.3	NP_001171712.1	voltage-dependent anion-selective channel protein 2 isoform 1
NM_001184823.2	NP_001171752.1	voltage-dependent anion-selective channel protein 2 isoform 2
NM_001324087.2	NP_001311016.1	voltage-dependent anion-selective channel protein 2 isoform 3
NM_001324088.2	NP_001311017.1	voltage-dependent anion-selective channel protein 2 isoform 2
NM_001324089.2	NP_001311018.1	voltage-dependent anion-selective channel protein 2 isoform 3
NM_001324090.2	NP_001311019.1	voltage-dependent anion-selective channel protein 2 isoform 3
NM_001391963.1	NP_001378892.1	voltage-dependent anion-selective channel protein 2 isoform 2
NM_003375.5	NP_003366.2	voltage-dependent anion-selective channel protein 2 isoform 2

基因本体论

分子功能
生物过程
细胞组分

分子功能 GO 注释	逻辑证据	参考文献	来源
enables ceramide binding	IDA IDA: 通过直接分析推断	31015432	GOA
enables cholesterol binding	IDA IDA: 通过直接分析推断	31015432	GOA
enables phosphatidylcholine binding	IDA IDA: 通过直接分析推断	31015432	GOA
enables phospholipid scramblase activity	IDA IDA: 通过直接分析推断	38065946	GOA
enables protein binding	IPI IPI: 通过物理相互作用推断	15082785	GOA
enables voltage-gated monoatomic anion channel activity	IDA IDA: 通过直接分析推断	8420959	GOA

生物过程 GO 注释	逻辑证据	参考文献	来源
involved in binding of sperm to zona pellucida	IMP IMP: 通过突变表型推断	23355646	GOA
involved in mitochondrial outer membrane permeabilization	IMP IMP: 通过突变表型推断	31015432	GOA
involved in mitochondrial transmembrane transport	IDA IDA: 通过直接分析推断	38065946	GOA
involved in monoatomic anion transport	IDA IDA: 通过直接分析推断	8420959	GOA
involved in phospholipid translocation	IDA IDA: 通过直接分析推断	38065946	GOA

细胞组分 GO 注释	逻辑证据	参考文献	来源
located in acrosomal vesicle	IDA IDA: 通过直接分析推断	23355646	GOA
located in membrane	IDA IDA: 通过直接分析推断	27641616	GOA
located in membrane raft	IDA IDA: 通过直接分析推断	25204797	GOA
located in mitochondrial membrane	IDA IDA: 通过直接分析推断	31015432	GOA
located in mitochondrial nucleoid	IDA IDA: 通过直接分析推断	18063578	GOA
located in mitochondrial outer membrane	IDA IDA: 通过直接分析推断	7539795	GOA

EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

VDAC2 蛋白结构

Porin_3

0
100
200
294 a.a.

蛋白主名

其他名称

voltage-dependent anion-selective channel protein 2

epididymis secretory sperm binding protein

VDAC2 蛋白互作信息

分类	蛋白名称	蛋白编号	互作蛋白	互作蛋白种属	互作蛋白编号	实验方法	参考文献
种属内	VDAC2	P45880	KIF1B	Homo sapiens	O60333-2	Validated Y2H	32814053
种属内	VDAC2	P45880	KIF1B	Homo sapiens	O60333-2	Y2H Pooling	32814053
种属内	VDAC2	P45880	KIF1B	Homo sapiens	O60333-2	Y2H Array	32814053
种属内	VDAC2	P45880	BAG6	Homo sapiens	P46379-2	Y2H Array	32814053
种属内	VDAC2	P45880	BAG6	Homo sapiens	P46379-2	Y2H Pooling	32814053
种属内	VDAC2	P45880	BAG6	Homo sapiens	P46379-2	Validated Y2H	32814053
种属内	VDAC2	P45880	CTSD	Homo sapiens	P07339	Validated Y2H	32814053
种属内	VDAC2	P45880	CTSD	Homo sapiens	P07339	Y2H Array	32814053
种属内	VDAC2	P45880	CTSD	Homo sapiens	P07339	Y2H Pooling	32814053
种属内	VDAC2	P45880	APBB2	Homo sapiens	Q92870-2	Validated Y2H	32814053
种属内	VDAC2	P45880	APBB2	Homo sapiens	Q92870-2	Y2H Pooling	32814053
种属内	VDAC2	P45880	APBB2	Homo sapiens	Q92870-2	Y2H Array	32814053
种属内	VDAC2	P45880	HSPB1	Homo sapiens	P04792	Y2H Pooling	32814053
种属内	VDAC2	P45880	HSPB1	Homo sapiens	P04792	Validated Y2H	32814053
种属内	VDAC2	P45880	HSPB1	Homo sapiens	P04792	Y2H Array	32814053
种属内	VDAC2	P45880	VDAC3	Homo sapiens	Q9Y277	Crosslink	30021884
种属内	VDAC2	P45880	CCT5	Homo sapiens	P48643	Y2H Pooling	32814053
种属内	VDAC2	P45880	CCT5	Homo sapiens	P48643	Validated Y2H	32814053
种属内	VDAC2	P45880	CCT5	Homo sapiens	P48643	Y2H Array	32814053
种属内	VDAC2	P45880	TPPP	Homo sapiens	O94811	Y2H Array	32814053
种属内	VDAC2	P45880	TPPP	Homo sapiens	O94811	Y2H Pooling	32814053
种属内	VDAC2	P45880	TPPP	Homo sapiens	O94811	Validated Y2H	32814053
种属内	VDAC2	P45880	RNF11	Homo sapiens	Q9Y3C5	Y2H Pooling	32814053
种属内	VDAC2	P45880	RNF11	Homo sapiens	Q9Y3C5	Validated Y2H	32814053
种属内	VDAC2	P45880	RNF11	Homo sapiens	Q9Y3C5	Y2H Array	32814053
种属内	VDAC2	P45880	NEFL	Homo sapiens	P07196	Validated Y2H	32814053
种属内	VDAC2	P45880	NEFL	Homo sapiens	P07196	Y2H Array	32814053
种属内	VDAC2	P45880	NEFL	Homo sapiens	P07196	Y2H Pooling	32814053
种属内	VDAC2	P45880	PMP22	Homo sapiens	A0A6Q8PF08	Y2H Pooling	32814053
种属内	VDAC2	P45880	PMP22	Homo sapiens	A0A6Q8PF08	Validated Y2H	32814053
种属内	VDAC2	P45880	PMP22	Homo sapiens	A0A6Q8PF08	Y2H Array	32814053
种属内	VDAC2	P45880	EEF1D	Homo sapiens	P29692-2	Y2H Array	32814053
种属内	VDAC2	P45880	EEF1D	Homo sapiens	P29692-2	Validated Y2H	32814053
种属内	VDAC2	P45880	EEF1D	Homo sapiens	P29692-2	Y2H Pooling	32814053
种属内	VDAC2	P45880	FAM162A	Homo sapiens	Q96A26	Anti Bait CoIP	15082785
种属内	VDAC2	P45880	ICAM5	Homo sapiens	Q9UMF0	Validated Y2H	32814053
种属内	VDAC2	P45880	ICAM5	Homo sapiens	Q9UMF0	Y2H Pooling	32814053
种属内	VDAC2	P45880	ICAM5	Homo sapiens	Q9UMF0	Y2H Array	32814053
种属内	VDAC2	P45880	TTR	Homo sapiens	P02766	Validated Y2H	32814053
种属内	VDAC2	P45880	TTR	Homo sapiens	P02766	Y2H Array	32814053
种属内	VDAC2	P45880	TTR	Homo sapiens	P02766	Y2H Pooling	32814053
种属内	VDAC2	P45880	WFS1	Homo sapiens	O76024	Validated Y2H	32814053
种属内	VDAC2	P45880	WFS1	Homo sapiens	O76024	Y2H Array	32814053
种属内	VDAC2	P45880	WFS1	Homo sapiens	O76024	Y2H Pooling	32814053
种属内	VDAC2	P45880	GRN	Homo sapiens	P28799	Y2H Pooling	32814053
种属内	VDAC2	P45880	GRN	Homo sapiens	P28799	Validated Y2H	32814053
种属内	VDAC2	P45880	GRN	Homo sapiens	P28799	Y2H Array	32814053
种属内	VDAC2	P45880	NDUFV1	Homo sapiens	P49821	Y2H Pooling	32814053
种属内	VDAC2	P45880	NDUFV1	Homo sapiens	P49821	Validated Y2H	32814053
种属内	VDAC2	P45880	NDUFV1	Homo sapiens	P49821	Y2H Array	32814053
种属内	VDAC2	P45880	PRPS1	Homo sapiens	P60891	Validated Y2H	32814053
种属内	VDAC2	P45880	PRPS1	Homo sapiens	P60891	Y2H Array	32814053
种属内	VDAC2	P45880	PRPS1	Homo sapiens	P60891	Y2H Pooling	32814053
种属内	VDAC2	P45880	PEX1	Homo sapiens	O43933	Y2H Array	32814053
种属内	VDAC2	P45880	PEX1	Homo sapiens	O43933	Y2H Pooling	32814053
种属内	VDAC2	P45880	PEX1	Homo sapiens	O43933	Validated Y2H	32814053

种属间: 跨种属相互作用 种属内: 同种属相互作用

关联疾病

疾病名称

别名

3-Methylglutaconic Aciduria, Type Iii

Optic Atrophy	3-Methylglutaconic Aciduria Type 3
Costeff Syndrome	Mga3
Costeff Optic Atrophy Syndrome	Optic Atrophy Plus Syndrome
Infantile Optic Atrophy With Chorea And Spastic Paraplegia	3-Methylglutaconic Aciduria Type Iii
Autosomal Recessive Optic Atrophy Plus Syndrome	Autosomal Recessive Optic Atrophy Type 3
Opa3 Defect	MGCA3
Mga, Type Iii	Iraqi Jewish Optic Atrophy Plus
Mga Type Iii	Optic Atrophy, Infantile, With Chorea And Spastic Paraplegia
Iraqi-Jewish 'Optic Atrophy Plus'	Optic Atrophy 3, Autosomal Recessive
Opa3, Autosomal Recessive	Opa3-Related 3-Methylglutaconic Aciduria
Iraqi-Jewish Optic Atrophy Plus	Atrophy Of Optic Disc
3-Alpha Methylglutaconic Aciduria Type Iii	Optic Atrophy 3
Optic Atrophy Infantile With Chorea And Spastic Paraplegia	Autosomal Recessive Opa3
Autosomal Recessive Optic Atrophy 3	3-Methylglutaconic Aciduria 3
3-Alpha-Methylglutaconic Aciduria Type 3	Optic Atrophy 3 Autosomal Recessive
Atrophy, Optic	Atrophy, Optic, Plus Syndrome
Optic Nerve Atrophy	Primary Optic Atrophy
Oa - [Optic Atrophy]	Second Cranial Nerve Atrophy
Second Cranium Nerve Atrophy

疾病名称	别名
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Cat. No.	产品名	作用方式	纯度	是否罕见病
HY-15763	Erastin		99.76%	否
HY-128777	WEHI-9625	Inhibitor	99.46%	否
HY-RS15630	VDAC2 Human Pre-designed siRNA Set A	Pre-designed Sets	/	否

直系同源

种属	基因名	来源	基因 ID
Mus musculus	VDAC2	MGD	MGI:106915
Rattus norvegicus	VDAC2	RGD	RGD:621576
Bos taurus	VDAC2	VGNC	VGNC:36783
Macaca mulatta	VDAC2	VGNC	VGNC:78763
Canis familiaris	VDAC2	VGNC	VGNC:48247
Felis catus	VDAC2	VGNC	VGNC:97682

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MedChemExpress (MCE) 只为有资质的科研机构、医药企业基于科学研究或药证申报的用途提供医药研发服务，不为任何个人或者非科研性质的、非用于药证申报使用等其他用途提供服务。

站点地图隐私声明

沪ICP备15051369号-4

上海工商

沪公网安备31011502019417

沪(浦)应急管危经许[2021]201709(QFYS)

营业执照（三证合一）

VDAC2 - voltage dependent anion channel 2 Gene

关于 VDAC2

功能概要

VDAC2 基因产物(8)

VDAC2 蛋白结构

VDAC2 蛋白互作信息

关联疾病

直系同源

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VDAC2 - voltage dependent anion channel 2 Gene

关于 VDAC2

功能概要

VDAC2 基因产物(8)

VDAC2 蛋白结构

VDAC2 蛋白互作信息

关联疾病

相关产品

直系同源

热门区域

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C

F

G

H

J

L

N

Q

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T

X

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