2. Gene
  3. VRK1 - VRK serine/threonine kinase 1 Gene

VRK1 - VRK serine/threonine kinase 1 Gene

  • 基因
  • 蛋白
  • 疾病
  • 相关产品
  • 直系同源

中文名称：VRK 丝氨酸/苏氨酸激酶 1

种属: Homo sapiens

同用名: PCH1; PCH1A

基因 ID: 7443 | 基因类型: protein coding

关于 VRK1

Cytogenetic location: 14q32.2 Genomic coordinates (GRCh38): 14:96,797,382-96,881,609 (from NCBI)

This gene has 63 transcripts (splice variants), 290 orthologues, 12 paralogues and is associated with 4 phenotypes. Broad expression in bone marrow (RPKM 15.9), testis (RPKM 12.9) and 23 other tissues.

功能概要

该基因编码丝氨酸/苏氨酸蛋白激酶的牛痘相关激酶 (VRK) 家族成员。该基因在人体组织中广泛表达，并在活跃分裂的细胞中表达增加，例如睾丸、胸腺、胎肝和癌中的细胞。其蛋白质定位于细胞核，已被证明可促进转录活性 p53 分子的稳定性和核积累，并在体外磷酸化 p53 的 Thr18 并减少 p53 泛素化。因此，该基因可能调节细胞增殖。这种蛋白质还磷酸化组蛋白、酪蛋白和转录因子 ATF2 (激活转录因子 2) 和 c-Jun。[RefSeq 提供，2008 年 7 月]

This gene encodes a member of the vaccinia-related kinase (VRK) family of serine/threonine protein kinases. This gene is widely expressed in human tissues and has increased expression in actively dividing cells, such as those in testis, thymus, fetal liver, and carcinomas. Its protein localizes to the nucleus and has been shown to promote the stability and nuclear accumulation of a transcriptionally active p53 molecule and, in vitro, to phosphorylate Thr18 of p53 and reduce p53 ubiquitination. This gene, therefore, may regulate cell proliferation. This protein also phosphorylates histone, casein, and the transcription factors ATF2 (activating transcription factor 2) and c-Jun. [provided by RefSeq, Jul 2008]

VRK1 基因产物(3)

mRNA Protein Name
NM_001411051.1 NP_001397980.1 serine/threonine-protein kinase VRK1 isoform 2
NM_001411053.1 NP_001397982.1 serine/threonine-protein kinase VRK1 isoform 3
NM_003384.3 NP_003375.1 serine/threonine-protein kinase VRK1 isoform 1

VRK1 蛋白结构

Pkinase

Pkinase: Protein kinase domain (39 - 278)

  • 0
  • 100
  • 200
  • 300
  • 396 a.a.
蛋白主名 其他名称

serine/threonine-protein kinase VRK1

vaccinia related kinase 1

VRK1 蛋白互作信息

分类
蛋白名称 蛋白编号 互作蛋白 互作蛋白种属 互作蛋白编号 实验方法 参考文献
种属内
VRK1 Q99986 ATF2 Homo sapiens P15336
Protein Kinase Assay
15105425
种属内
VRK1 Q99986 RAN Homo sapiens P62826
Anti Bait CoIP
18617507
种属内
VRK1 Q99986 RAN Homo sapiens P62826
Pull Down
18617507
种属内
VRK1 Q99986 TP53 Homo sapiens P04637
Pull Down
24492002
种属内
VRK1 Q99986 TP53 Homo sapiens P04637
Anti Bait CoIP
24492002
种属内
VRK1 Q99986 TP53 Homo sapiens P04637
Protein Kinase Assay
29340707
种属内
VRK1 Q99986 TP53 Homo sapiens P04637
Anti Tag CoIP
24492002
种属内
VRK1 Q99986 RNF8 Homo sapiens O76064
Anti Tag CoIP
26869104
种属内
VRK1 Q99986 TP53BP1 Homo sapiens Q12888
Phosphotransferase
22621922
种属内
VRK1 Q99986 TP53BP1 Homo sapiens Q12888
Anti Bait CoIP
22621922
种属内
VRK1 Q99986 KAT5 Homo sapiens Q92993
Anti Bait CoIP
33076429
种属内
VRK1 Q99986 KAT5 Homo sapiens Q92993
Pull Down
33076429
种属内
VRK1 Q99986 KAT5 Homo sapiens Q92993
Anti Tag CoIP
33076429
种属内
VRK1 Q99986 KAT5 Homo sapiens Q92993
Protein Kinase Assay
33076429
种属内
VRK1 Q99986 H2AX Homo sapiens P16104
Anti Bait CoIP
25923214
种属内
VRK1 Q99986 SOX2 Homo sapiens P48431
Pull Down
27334688
种属内
VRK1 Q99986 SOX2 Homo sapiens P48431
Confocal
27334688
种属内
VRK1 Q99986 AURKB Homo sapiens Q96GD4
Pull Down
29340707
种属内
VRK1 Q99986 AURKB Homo sapiens Q96GD4
Confocal
29340707
种属内
VRK1 Q99986 AURKB Homo sapiens Q96GD4
Protein Kinase Assay
29340707
种属内
VRK1 Q99986 AURKB Homo sapiens Q96GD4
Anti Bait CoIP
29340707
种属内
VRK1 Q99986 AURKB Homo sapiens Q96GD4
Anti Tag CoIP
29340707
种属内
VRK1 Q99986 PLK3 Homo sapiens Q9H4B4
Pull Down
19103756
种属内
VRK1 Q99986 PLK3 Homo sapiens Q9H4B4
Confocal
19103756
种属内
VRK1 Q99986 PLK3 Homo sapiens Q9H4B4
Anti Bait CoIP
19103756
种属内
VRK1 Q99986 PLK3 Homo sapiens Q9H4B4
Anti Tag CoIP
19103756
种属内
VRK1 Q99986 COIL Homo sapiens P38432
Pull Down
21920476
种属内
VRK1 Q99986 COIL Homo sapiens P38432
Confocal
21920476
种属内
VRK1 Q99986 COIL Homo sapiens P38432
Anti Bait CoIP
21920476
种属内
VRK1 Q99986 COIL Homo sapiens P38432
Protein Kinase Assay
21920476
种属间: 跨种属相互作用 种属内: 同种属相互作用

重组 VRK1 蛋白

目录号 产品名 蛋白编号 纯度
HY-P77504 VRK1 Protein, Human (sf9) Q99986 (N-G&P, M1-K396) ≥95%

关联疾病

疾病名称 别名
Pontocerebellar Hypoplasia, Type 1a

Pontocerebellar Hypoplasia Type 1a

PCH1A

Pontocerebellar Hypoplasia With Infantile Spinal Muscular Atrophy

Pontocerebellar Hypoplasia With Anterior Horn Cell Disease

Pch1

Pontocerebellar Hypoplasia 1a

Hypoplasia, Pontocerebellar, Type 1a

Pontocerebellar Hypoplasia Type 1
Microcephaly-Complex Motor And Sensory Axonal Neuropathy Syndrome
Pontocerebellar Hypoplasia, Type 1e

Pontocerebellar Hypoplasia Type 1

PCH1E

Norman Disease

Pch1

Pontocerebellar Hypoplasia With Anterior Horn Cell Disease

Pontocerebellar Hypoplasia With Infantile Spinal Muscular Atrophy

Pontocerebellar Hypoplasia Type 1e

Pontocerebellar Hypoplasia 1e

Doid:0112322

Doid:0112330
Spinal Muscular Atrophy

Sma

5q Sma

Proximal Sma

Sma-Associated Sma

Spinal Amyotrophies

Spinal Amyotrophy

Spinal Muscle Degeneration

Spinal Muscle Wasting

Muscular Atrophy Spinal

Atrophy, Muscular, Spinal

Hereditary Motor Neuronopathy

Progressive Muscular Atrophy

Sma - [Spinal Muscular Atrophy]
Vaccinia
Pontocerebellar Hypoplasia, Type 1b

Pontocerebellar Hypoplasia Type 1b

PCH1B

Pontocerebellar Hypoplasia 1b

Hypoplasia, Pontocerebellar, Type 1b
Pontocerebellar Hypoplasia

Pch

Congenital Pontocerebellar Hypoplasia

Opch

Hypoplasia, Pontocerebellar

Pontoneocerebellar Hypoplasia

Nonsyndromic Pontocerebellar Hypoplasia
Charcot-Marie-Tooth Hereditary Neuropathy

Distal Spinal Muscular Atrophy

Distal Hereditary Motor Neuropathy

Dhmn

Hereditary Motor/Sensory Neuropathy

Hmsn

Dsma

Distal Hereditary Motor Neuropathies

Spinal Muscular Atrophy Distal

Neuropathy, Motor, Distal, Hereditary

Charcot-Marie-Tooth Disease
Juvenile Amyotrophic Lateral Sclerosis

Jals

Juvenile Charcot Disease

Juvenile Lou Gehrig Disease

Amyotrophic Lateral Sclerosis, Juvenile
Non-Syndromic Pontocerebellar Hypoplasia

Pontoneocerebellar Hypoplasia

Pch

Pontoneocerebellar Atrophy
Muscular Atrophy

Muscle Wasting

Amyotrophia

Wasting - Muscle

Skeletal Muscle Atrophy
Hereditary Breast Ovarian Cancer Syndrome

Hereditary Breast And Ovarian Cancer Syndrome

Brca1- And Brca2-Associated Hereditary Breast And Ovarian Cancer

Breast And/Or Ovarian Cancer

Breast And Ovarian Cancer Syndrome

Hboc Syndrome

Hereditary Breast And Ovarian Cancer

Brca1- Brca2-Associated Hboc
Congenital Contractures

Congenital Contracture
Motor Neuron Disease

Anterior Horn Cell Disease

Motor Neuron Diseases

Mnd - [Motor Neurone Disease]

Lou Gehrig Disease

Creeping Palsy

Creeping Paralysis

Bulbar Motor Neuron Disease

Bulbar Syndrome

Anterior Horn Cell Disorder

Hereditary Motor Neuron Disease
Epidermolysis Bullosa, Junctional 1b, Severe

Epidermolysis Bullosa, Junctional, Herlitz Type

Epidermolysis Bullosa Letalis

JEB1B

Epidermolysis Bullosa Junctionalis, Herlitz Type

Jeb-Herlitz Type

Herlitz-Pearson-Type Epidermolysis Bullosa

Junctional Epidermolysis Bullosa Herlitz Type

Jeb-H

Junctional Epidermolysis Bullosa Generalisata Gravis

Junctional Epidermolysis Bullosa, Herlitz-Pearson Type

Epidermolysis Bullosa, Junctional, Generalized Severe

Epidermolysis Bullosa, Junctional, Herlitz-Pearson Type

Herlitz Type Epidermolysis Bullosa Junctionalis

Severe Generalized Junctional Epidermolysis Bullosa

Junctional Epidermolysis Bullosa, Herlitz Type

Severe Generalized Jeb

Epidermolysis Letalis

Junctional Epidermolysis Bullosa Gravis

Junctional Epidermolysis Bullosa Herlitz-Pearson Type

Herlitz Disease
Microcephaly

Microencephaly

Microcephalus

Microcephalic

Nanocephaly

Congenital Microcephaly

Brain Hypoplasia

Brain Nondevelopment

Cephalic Hypoplasia

Undeveloped Cerebrum

Undeveloped Brain

Micrencephalon

Micrencephaly
Joubert Syndrome 1

Joubert Syndrome

Jbts

Cerebellooculorenal Syndrome 1

JBTS1

Joubert-Boltshauser Syndrome

Cerebelloparenchymal Disorder Iv

Cpd4

Cors1

Joubert Syndrome And Related Disorders

Jsrd

Familial Aplasia Of The Vermis

Joubert Syndrome Related Disorders

Js

Cerebellar Vermis Agenesis

Cerebelloparenchymal Disorder 4

Agenesis Of Cerebellar Vermis

Cerebello-Oculo-Renal Syndrome

Cors

Joubert-Bolthauser Syndrome

Cpd Iv

Classic Joubert Syndrome

Joubert Syndrome Type A

Pure Joubert Syndrome

Cerebello-Oculo-Renal Syndrome 1

Joubert Syndrome-1

Joubert Syndrome, Type 1

Joubert'S Syndrome
Congenital Nervous System Abnormality

Congenital Neurologic Anomaly

Congenital Nervous System Disorder
疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

相关产品

Pre-clinical Phase
生物活性分子 (3)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-126542 VRK-IN-1 Inhibitor 99.47% 否
HY-158975 VRK1/CK1-IN-1 Inhibitor 98.69% 否
HY-RS15702 VRK1 Human Pre-designed siRNA Set A Pre-designed Sets / 否

直系同源

种属 基因名 来源 基因 ID
Felis catus VRK1 VGNC VGNC:80780
Canis familiaris VRK1 VGNC VGNC:48302
Bos taurus VRK1 VGNC VGNC:36834
Mus musculus VRK1 MGD MGI:1261847
Macaca mulatta VRK1 VGNC VGNC:81603
Rattus norvegicus VRK1 RGD RGD:1306069
Others VRK1 NCBI
嗨！很高兴为您提供帮助！

尊敬的 MCE 客户您好，
请您选择所在区域，我们将转接对应客服为您服务！

热门区域

A

B

C

F

G

H

J

L

N

Q

S

T

X

Y

Z

热 A B C F G H J L N Q S T X Y Z