ZBTB17 - zinc finger and BTB domain containing 17 Gene

中文名称：含锌指和 BTB 域 17

种属: Homo sapiens

同用名: MIZ-1; ZNF60; ZNF151; pHZ-67

基因 ID: 7709 | 基因类型: protein coding

关于 ZBTB17

Cytogenetic location: 1p36.13 Genomic coordinates (GRCh38): 1:15,941,869-15,976,101 (from NCBI)

This gene has 16 transcripts (splice variants), 208 orthologues and 51 paralogues. Ubiquitous expression in bone marrow (RPKM 10.4), testis (RPKM 10.3) and 25 other tissues.

功能概要

该基因编码参与 c-Myc 调节的锌指蛋白。符号 MIZ1 也与 PIAS2 有关，PIAS2 是位于 18 号染色体上的不同基因。[RefSeq 提供，2008 年 7 月]

This gene encodes a zinc finger protein involved in the regulation of c-Myc. The symbol MIZ1 has also been associated with PIAS2 which is a different gene located on chromosome 18. [provided by RefSeq, Jul 2008]

ZBTB17 基因产物(6)

mRNA	Protein	Name
NM_001242884.2	NP_001229813.1	zinc finger and BTB domain-containing protein 17 isoform 1
NM_001287603.2	NP_001274532.1	zinc finger and BTB domain-containing protein 17 isoform 3
NM_001287604.2	NP_001274533.1	zinc finger and BTB domain-containing protein 17 isoform 4
NM_001324137.2	NP_001311066.1	zinc finger and BTB domain-containing protein 17 isoform 4
NM_001324138.2	NP_001311067.1	zinc finger and BTB domain-containing protein 17 isoform 5
NM_003443.3	NP_003434.2	zinc finger and BTB domain-containing protein 17 isoform 2

基因本体论

分子功能
生物过程
细胞组分

分子功能 GO 注释	逻辑证据	参考文献	来源
enables DNA-binding transcription activator activity, RNA polymerase II-specific	IDA IDA: 通过直接分析推断	9312026	GOA
enables DNA-binding transcription activator activity, RNA polymerase II-specific	IMP IMP: 通过突变表型推断	9312026	GOA
enables DNA-binding transcription factor activity	IDA IDA: 通过直接分析推断	12244100	GOA
enables DNA-binding transcription factor binding	IPI IPI: 通过物理相互作用推断	19160485	GOA
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding	IMP IMP: 通过突变表型推断	9312026	GOA
enables core promoter sequence-specific DNA binding	IDA IDA: 通过直接分析推断	19160485	GOA
enables protein binding	IPI IPI: 通过物理相互作用推断	9308237	GOA
enables transcription coactivator binding	IPI IPI: 通过物理相互作用推断	19160485	GOA

生物过程 GO 注释	逻辑证据	参考文献	来源
acts upstream of negative effect G1 to G0 transition	IDA IDA: 通过直接分析推断	19160485	GOA
involved in negative regulation of cell population proliferation	IDA IDA: 通过直接分析推断	19160485	GOA
involved in positive regulation of transcription by RNA polymerase II	IDA IDA: 通过直接分析推断	9312026	GOA
involved in positive regulation of transcription by RNA polymerase II	IMP IMP: 通过突变表型推断	19160485	GOA

细胞组分 GO 注释	逻辑证据	参考文献	来源
part of protein-DNA complex	IMP IMP: 通过突变表型推断	19160485	GOA
part of protein-containing complex	IDA IDA: 通过直接分析推断	19160485	GOA

EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

ZBTB17 蛋白结构

BTB

zf-H2C2_2

zf-C2H2_6

zf-H2C2_2

zf-C2H2_4

0
200
400
600
803 a.a.

蛋白主名

其他名称

zinc finger and BTB domain-containing protein 17

Myc-interacting Zn finger protein-1

重组 ZBTB17 蛋白

目录号	产品名	蛋白编号	纯度
HY-P71437	ZBTB17 Protein, Human (His)	Q13105 (M1-A188)	≥95%

关联疾病

疾病名称

别名

Dilated Cardiomyopathy

Familial Dilated Cardiomyopathy	Primary Dilated Cardiomyopathy
Idiopathic Dilated Cardiomyopathy	Congestive Cardiomyopathy
Idiopathic Dilation Cardiomyopathy	Primary Familial Dilated Cardiomyopathy
Cardiomyopathy, Dilated	DCM
Cardiomyopathy, Familial Dilated	Dilated Cardiomyopathy, Familial
Hypokinetic Dilated Cardiomyopathy, Familial	Familial Idiopathic Cardiomyopathy
Fdc	Cardiomyopathy, Familial Idiopathic
Idiopathic Cardiomegaly	Dilated Congestive Cardiomyopathy
Chronic Dilated Cardiomyopathy	Ccm - [Congestive Cardiomyopathy]
Cocm - [Congestive Cardiomyopathy]	Dcm - [Dilated Cardiomyopathy]
Dilated-Hypokinetic Cardiomyopathy	Congestive Idiopathic Cardiomyopathy
Primary Idiopathic Dilated Cardiomyopathy

疾病名称	别名
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Cat. No.	产品名	作用方式	纯度	是否罕见病
HY-RS15965	ZBTB17 Human Pre-designed siRNA Set A	Pre-designed Sets	/	否

直系同源

种属	基因名	来源	基因 ID
Canis familiaris	ZBTB17	VGNC	VGNC:48525
Mus musculus	ZBTB17	MGD	MGI:107410
Rattus norvegicus	ZBTB17	RGD	RGD:1307143
Bos taurus	ZBTB17	VGNC	VGNC:52849
Macaca mulatta	ZBTB17	VGNC	VGNC:78849
Felis catus	ZBTB17	VGNC	VGNC:67163
Others	ZBTB17	NCBI

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