1. Gene
  2. RNF112 - ring finger protein 112 Gene

RNF112 - ring finger protein 112 Gene

中文名称:无名指蛋白 112

种属: Homo sapiens

同用名: BFP; ZNF179

基因 ID: 7732 | 基因类型: protein coding

关于 RNF112

Cytogenetic location: 17p11.2 Genomic coordinates (GRCh38): 17:19,411,232-19,417,276 (from NCBI)

This gene has 5 transcripts (splice variants), 129 orthologues and 10 paralogues. Biased expression in brain (RPKM 6.0), prostate (RPKM 2.1) and 11 other tissues.

功能概要

该基因编码 RING 指蛋白转录因子家族的成员。该蛋白质主要在大脑中表达。该基因位于 17 号染色体上的 Smith-Magenis 综合征区域内。[RefSeq 提供,2008 年 7 月]

This gene encodes a member of the RING finger protein family of transcription factors. The protein is primarily expressed in brain. The gene is located within the Smith-Magenis syndrome region on chromosome 17. [provided by RefSeq, Jul 2008]

RNF112 基因产物(1)

mRNA Protein Name
NM_007148.5 NP_009079.2 RING finger protein 112
基因本体论
  • 分子功能
  • 生物过程
分子功能 GO 注释 逻辑证据 参考文献 来源
enables protein binding IPI
IPI: 通过物理相互作用推断
32814053 GOA
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in neuron differentiation IDA
IDA: 通过直接分析推断
28684796 GOA
involved in regulation of cell cycle IDA
IDA: 通过直接分析推断
28684796 GOA
EXP:通过实验结果推断 IDA:通过直接分析推断 IPI:通过物理相互作用推断 IMP:通过突变表型推断 IGI:通过遗传相互作用推断 IEP:通过表达模式推断

RNF112 蛋白结构

zf-C3HC4

zf-C3HC4: Zinc finger, C3HC4 type (RING finger) (57 - 97)

GBP

GBP: Guanylate-binding protein, N-terminal domain (163 - 328)

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  • 500
  • 631 a.a.
蛋白主名 其他名称

RING finger protein 112

brain finger protein

RNF112 蛋白互作信息

分类
蛋白名称 蛋白编号 互作蛋白 互作蛋白种属 互作蛋白编号 实验方法 参考文献
种属内
RNF112 Q9ULX5 PSEN1 Homo sapiens P49768-2
Validated Y2H
32814053
种属内
RNF112 Q9ULX5 PSEN1 Homo sapiens P49768-2
Y2H Array
32814053
种属内
RNF112 Q9ULX5 PSEN1 Homo sapiens P49768-2
Y2H Pooling
32814053
种属内
RNF112 Q9ULX5 PARK7 Homo sapiens Q99497
Validated Y2H
32814053
种属内
RNF112 Q9ULX5 PARK7 Homo sapiens Q99497
Y2H Array
32814053
种属内
RNF112 Q9ULX5 PARK7 Homo sapiens Q99497
Y2H Pooling
32814053
种属内
RNF112 Q9ULX5 MECP2 Homo sapiens P51608
Validated Y2H
32814053
种属内
RNF112 Q9ULX5 MECP2 Homo sapiens P51608
Y2H Pooling
32814053
种属内
RNF112 Q9ULX5 MECP2 Homo sapiens P51608
Y2H Array
32814053
种属内
RNF112 Q9ULX5 APP Homo sapiens P05067-2
Validated Y2H
32814053
种属内
RNF112 Q9ULX5 APP Homo sapiens P05067-2
Y2H Pooling
32814053
种属内
RNF112 Q9ULX5 APP Homo sapiens P05067-2
Y2H Array
32814053
种属内
RNF112 Q9ULX5 PRKN Homo sapiens O60260-5
Y2H Array
32814053
种属内
RNF112 Q9ULX5 PRKN Homo sapiens O60260-5
Y2H Pooling
32814053
种属内
RNF112 Q9ULX5 PRKN Homo sapiens O60260-5
Validated Y2H
32814053
种属内
RNF112 Q9ULX5 ELAVL4 Homo sapiens P26378-2
Validated Y2H
32814053
种属内
RNF112 Q9ULX5 ELAVL4 Homo sapiens P26378-2
Y2H Pooling
32814053
种属内
RNF112 Q9ULX5 ELAVL4 Homo sapiens P26378-2
Y2H Array
32814053
种属内
RNF112 Q9ULX5 DCTN1 Homo sapiens Q14203-5
Validated Y2H
32814053
种属内
RNF112 Q9ULX5 DCTN1 Homo sapiens Q14203-5
Y2H Array
32814053
种属内
RNF112 Q9ULX5 DCTN1 Homo sapiens Q14203-5
Y2H Pooling
32814053
种属内
RNF112 Q9ULX5 RNF11 Homo sapiens Q9Y3C5
Validated Y2H
32814053
种属内
RNF112 Q9ULX5 RNF11 Homo sapiens Q9Y3C5
Y2H Pooling
32814053
种属内
RNF112 Q9ULX5 RNF11 Homo sapiens Q9Y3C5
Y2H Array
32814053
种属内
RNF112 Q9ULX5 PMP22 Homo sapiens A0A6Q8PF08
Y2H Pooling
32814053
种属内
RNF112 Q9ULX5 PMP22 Homo sapiens A0A6Q8PF08
Validated Y2H
32814053
种属内
RNF112 Q9ULX5 PMP22 Homo sapiens A0A6Q8PF08
Y2H Array
32814053
种属内
RNF112 Q9ULX5 A2M Homo sapiens P01023
Validated Y2H
32814053
种属内
RNF112 Q9ULX5 A2M Homo sapiens P01023
Y2H Pooling
32814053
种属内
RNF112 Q9ULX5 A2M Homo sapiens P01023
Y2H Array
32814053
种属内
RNF112 Q9ULX5 NDUFV2 Homo sapiens P19404
Y2H Array
32814053
种属内
RNF112 Q9ULX5 NDUFV2 Homo sapiens P19404
Validated Y2H
32814053
种属内
RNF112 Q9ULX5 NDUFV2 Homo sapiens P19404
Y2H Pooling
32814053
种属内
RNF112 Q9ULX5 UCHL1 Homo sapiens P09936
Y2H Array
32814053
种属内
RNF112 Q9ULX5 UCHL1 Homo sapiens P09936
Y2H Pooling
32814053
种属内
RNF112 Q9ULX5 UCHL1 Homo sapiens P09936
Validated Y2H
32814053
种属内
RNF112 Q9ULX5 PHYH Homo sapiens O14832
Validated Y2H
32814053
种属内
RNF112 Q9ULX5 PHYH Homo sapiens O14832
Y2H Array
32814053
种属内
RNF112 Q9ULX5 PHYH Homo sapiens O14832
Y2H Pooling
32814053
种属内
RNF112 Q9ULX5 GRN Homo sapiens P28799
Validated Y2H
32814053
种属内
RNF112 Q9ULX5 GRN Homo sapiens P28799
Y2H Pooling
32814053
种属内
RNF112 Q9ULX5 GRN Homo sapiens P28799
Y2H Array
32814053
种属内
RNF112 Q9ULX5 OPTN Homo sapiens Q96CV9
Y2H Pooling
32814053
种属内
RNF112 Q9ULX5 OPTN Homo sapiens Q96CV9
Validated Y2H
32814053
种属内
RNF112 Q9ULX5 OPTN Homo sapiens Q96CV9
Y2H Array
32814053
种属内
RNF112 Q9ULX5 PRPH Homo sapiens P41219
Validated Y2H
32814053
种属内
RNF112 Q9ULX5 PRPH Homo sapiens P41219
Y2H Array
32814053
种属内
RNF112 Q9ULX5 PRPH Homo sapiens P41219
Y2H Pooling
32814053
种属内
RNF112 Q9ULX5 DBH Homo sapiens P09172
Validated Y2H
32814053
种属内
RNF112 Q9ULX5 DBH Homo sapiens P09172
Y2H Array
32814053
种属内
RNF112 Q9ULX5 DBH Homo sapiens P09172
Y2H Pooling
32814053
种属间: 跨种属相互作用 种属内: 同种属相互作用

关联疾病

疾病名称 别名
Smith-Magenis Syndrome

SMS

Chromosome 17p11.2 Deletion Syndrome

17p11.2 Microdeletion Syndrome

17p11.2 Monosomy

Chromosome 17p Deletion Syndrome

Del(17)

P11.2

17p- Syndrome

Deletion 17p Syndrome

Partial Monosomy 17p

Bilateral Generalized Polymicrogyria

Bilateral Generalised Polymicrogyria

Acute Diarrhea
Miller Fisher Syndrome

Cranial Variant Of Gbs

Fisher'S Syndrome

Miller-Fisher Variant Of Guillain-Barre Syndrome

Miller-Fisher Syndrome

Cranial Variant Of Guillain-Barré Syndrome

Cranial Variant Of Guillain-Barre Syndrome

Fisher Syndrome

Gummatous Syphilis
Bilateral Frontal Polymicrogyria
Myopathy, Centronuclear, 1

Autosomal Dominant Centronuclear Myopathy

CNM1

Centronuclear Myopathy 1

Ad-Cnm

Myopathy, Centronuclear, Autosomal Dominant

Myotubular Myopathy, Autosomal Dominant

Centronuclear Myopathy, Autosomal, Modifier Of

Autosomal Dominant Myotubular Myopathy

Dnm2-Related Centronuclear Myopathy

Centronuclear Myopathy Autosomal Dominant

Myopathies, Structural, Congenital

Myopathy, Centronuclear, Type 1

Yaws

Frambesia

Frambesia Tropica

Bouba

Frambosie

Polypapilloma Tropicum

Thymosis

Endemic Treponematoses

Treponema Pertenue Infection

Pian

Framboesia

Framboesia Tropica

Castellani

Infection By Treponema Pertenue

Parangi

Framboesioma

Chancre Of Yaws

Primary Framboesia

Initial Lesions Of Yaws

Mother Yaw

Initial Framboesia

Loeys-Dietz Syndrome 2

LDS2

Aat3

Marfan Syndrome Type 2

Aortic Aneurysm, Familial Thoracic 3

Marfan Syndrome Type Ii

Loeys-Dietz Syndrome Type 2

Mfs2

Marfan Syndrome, Type Ii, Formerly

Familial Throacic Aortic Aneurysm 3

Familial Aortic Aneurysm Thoracic Type 3

Taad2

Thoracic Aortic Aneurysms And Dissection 2

Aneurysm, Aortic, Thoracic, Familial, Type 3

Loeys-Dietz Syndrome, Type 2

疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

直系同源

种属 基因名 来源 基因 ID
Mus musculus RNF112 MGD MGI:106611
Canis familiaris RNF112 VGNC VGNC:45622
Rattus norvegicus RNF112 RGD RGD:3986
Macaca mulatta RNF112 VGNC VGNC:76724
Bos taurus RNF112 VGNC VGNC:34011
Felis catus RNF112 VGNC VGNC:64664