Brpf1 - bromodomain and PHD finger containing, 1 Gene

中文名称：含溴结构域和 PHD 手指，1

种属: Mus musculus

同用名: Brpf2; 4833438B11Rik; 4930540D11Rik

关于 Brpf1

功能概要

预测该基因编码的蛋白可启动乙酰转移酶激活剂活性和组蛋白结合活性。参与组蛋白 H3-K23 乙酰化。作用于普通骨髓祖细胞增殖的上游或内部；调节成纤维细胞增殖；和管形态发生。预测位于胞质溶胶中；核;和质膜。预计是 MOZ/MORF 组蛋白乙酰转移酶复合物的一部分。以多种结构表达，包括消化系统；中枢神经系统;早孕;泌尿生殖系统；和感觉器官。用于研究综合征性智力障碍。与人类 BRPF1 同源（溴结构域和 PHD 指包含 1）。 [由基因组资源联盟提供，2022 年 4 月]

Predicted to enable acetyltransferase activator activity and histone binding activity. Involved in histone H3-K23 acetylation. Acts upstream of or within common myeloid progenitor cell proliferation; regulation of fibroblast proliferation; and tube morphogenesis. Predicted to be located in cytosol; nucleus; and plasma membrane. Predicted to be part of MOZ/MORF Histone Acetyltransferase complex. Is expressed in several structures, including alimentary system; central nervous system; early conceptus; genitourinary system; and sensory organ. Used to study syndromic intellectual disability. Orthologous to human BRPF1 (bromodomain and PHD finger containing 1). [provided by Alliance of Genome Resources, Apr 2022]