DUSP26 - dual specificity phosphatase 26 Gene

中文名称：双特异性磷酸酶 26

种属: Homo sapiens

同用名: LDP4; MKP8; NEAP; DSP-4; LDP-4; MKP-8; NATA1; SKRP3; DUSP24

关于 DUSP26

功能概要

该基因编码酪氨酸磷酸酶蛋白家族的一个成员，并通过使酪氨酸以及丝氨酸和苏氨酸残基去磷酸化而表现出双重特异性。根据细胞环境，该基因被描述为肿瘤抑制基因和致癌基因。这种蛋白质可以调节神经元增殖，并通过其使 p53 肿瘤抑制因子去磷酸化的能力参与胶质母细胞瘤的进展。可变剪接导致多个转录本变体。[RefSeq 提供，2015 年 2 月]

This gene encodes a member of the tyrosine Phosphatase family of proteins and exhibits dual specificity by dephosphorylating tyrosine as well as serine and threonine residues. This gene has been described as both a tumor suppressor and an oncogene depending on the cellular context. This protein may regulate neuronal proliferation and has been implicated in the progression of glioblastoma through its ability to dephosphorylate the p53 tumor suppressor. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Feb 2015]