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  2. ATG9A - autophagy related 9A Gene

ATG9A - autophagy related 9A Gene

中文名称:自噬相关 9A

种属: Homo sapiens

同用名: mATG9; APG9L1; MGD3208

基因 ID: 79065 | 基因类型: protein coding

关于 ATG9A

Cytogenetic location: 2q35 Genomic coordinates (GRCh38): 2:219,219,380-219,229,636 (from NCBI)

This gene has 21 transcripts (splice variants), 206 orthologues and 1 paralogue. Broad expression in testis (RPKM 45.2), brain (RPKM 19.5) and 25 other tissues.

功能概要

在自噬体组装的上游或内部起作用。位于核内体;吞噬细胞组装位点;和跨高尔基网络。 [由基因组资源联盟提供,2022 年 4 月]

Acts upstream of or within autophagosome assembly. Located in endosome; phagophore assembly site; and trans-Golgi network. [provided by Alliance of Genome Resources, Apr 2022]

ATG9A 基因产物(2)

mRNA Protein Name
NM_001077198.3 NP_001070666.1 autophagy-related protein 9A
NM_024085.5 NP_076990.4 autophagy-related protein 9A
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables phospholipid scramblase activity IDA
IDA: 通过直接分析推断
33106659 GOA
enables protein binding IPI
IPI: 通过物理相互作用推断
19893488 GOA
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in autophagosome assembly IDA
IDA: 通过直接分析推断
29437695 GOA
acts upstream of or within autophagosome assembly IMP
IMP: 通过突变表型推断
15755735 GOA
involved in autophagosome assembly IMP
IMP: 通过突变表型推断
29180427 GOA
细胞组分 GO 注释 逻辑证据 参考文献 来源
located in Golgi apparatus IDA
IDA: 通过直接分析推断
34432599 GOA
located in Golgi membrane IDA
IDA: 通过直接分析推断
27663665 GOA
NOT located in autophagosome membrane IDA
IDA: 通过直接分析推断
22456507 GOA
located in endoplasmic reticulum membrane IDA
IDA: 通过直接分析推断
27316455 GOA
located in endosome IDA
IDA: 通过直接分析推断
23093945 GOA
located in late endosome IDA
IDA: 通过直接分析推断
22456507 GOA
located in mitochondrion IDA
IDA: 通过直接分析推断
34432599 GOA
located in phagophore assembly site IDA
IDA: 通过直接分析推断
22456507 GOA
located in recycling endosome IDA
IDA: 通过直接分析推断
22456507 GOA
located in recycling endosome membrane IDA
IDA: 通过直接分析推断
29437695 GOA
located in trans-Golgi network IDA
IDA: 通过直接分析推断
22456507 GOA
EXP:通过实验结果推断 IDA:通过直接分析推断 IPI:通过物理相互作用推断 IMP:通过突变表型推断 IGI:通过遗传相互作用推断 IEP:通过表达模式推断

ATG9A 蛋白结构

APG9

APG9: Autophagy protein Apg9 (174 - 532)

  • 0
  • 200
  • 400
  • 600
  • 839 a.a.
蛋白主名 其他名称

autophagy-related protein 9A

APG9 autophagy 9-like 1

ATG9A 蛋白互作信息

分类
蛋白名称 蛋白编号 互作蛋白 互作蛋白种属 互作蛋白编号 实验方法 参考文献
Intra ATG9A Q7Z3C6 KRTAP4-2 Homo sapiens Q9BYR5
Validated Y2H
25416956
Intra ATG9A Q7Z3C6 KRTAP4-2 Homo sapiens Q9BYR5
Y2H Prey Pooling
25416956
Intra ATG9A Q7Z3C6 UBE3A Homo sapiens Q05086-2
Y2H Array
25416956
Intra ATG9A Q7Z3C6 UBE3A Homo sapiens Q05086-2
Y2H Prey Pooling
25416956
Intra ATG9A Q7Z3C6 AP2M1 Homo sapiens Q96CW1
FPS
33436498
Intra ATG9A Q7Z3C6 AP2M1 Homo sapiens Q96CW1
Pull Down
24603492
Intra ATG9A Q7Z3C6 REL Homo sapiens Q04864
Validated Y2H
25416956
Intra ATG9A Q7Z3C6 TBK1 Homo sapiens Q9UHD2
Anti Tag CoIP
21903422
Intra ATG9A Q7Z3C6 KRTAP5-9 Homo sapiens P26371
Y2H Prey Pooling
25416956
Intra ATG9A Q7Z3C6 SUPT20H Homo sapiens Q8NEM7-2
Y2H
19893488
Intra ATG9A Q7Z3C6 SUPT20H Homo sapiens Q8NEM7-2
Anti Bait CoIP
19893488
Intra ATG9A Q7Z3C6 NOTCH2NLA Homo sapiens Q7Z3S9
Y2H Prey Pooling
25416956
Intra ATG9A Q7Z3C6 KRT31 Homo sapiens Q15323
Y2H Prey Pooling
25416956
Intra ATG9A Q7Z3C6 KRT31 Homo sapiens Q15323
Y2H Array
25416956
种属间: 跨种属相互作用 种属内: 同种属相互作用

关联疾病

疾病名称 别名
Spastic Paraplegia 52, Autosomal Recessive

SPG52

Hereditary Spastic Paraplegia 52

Cpsq6

Cerebral Palsy, Spastic Quadriplegic, 6, Formerly

Cpsq6, Formerly

Autosomal Recessive Spastic Paraplegia 52

Spastic Quadriplegic Cerebral Palsy 6

Cerebral Palsy, Spastic Quadriplegic 6

Spastic Paraplegia 50, Autosomal Recessive

Hereditary Spastic Paraplegia 50

SPG50

Ap-4 Deficiency Syndrome

Ap-4-Associated Hereditary Spastic Paraplegia

Adaptor Protein Complex 4 Deficiency

Cerebral Palsy, Spastic Quadriplegic, 3, Formerly

Cpsq3, Formerly

Autosomal Recessive Spastic Paraplegia 50

Cpsq3

Spastic Quadriplegic Cerebral Palsy 3

Ap-4 Deficiency

Ap-4-Associated Hsp

Paraplegia, Spastic, Autosomal Recessive, Type 50

Spastic Paraplegia-50, Autosomal Recessive

Hereditary Spastic Paraplegia

Familial Spastic Paraplegia

Hereditary Spastic Paraparesis

Strumpell-Lorrain Disease

Familial Spastic Paraparesis

Hsp

Spg

Strümpell-Lorrain Disease

Spastic Paraplegia, Hereditary

French Settlement Disease

Strumpell-Lorrain Syndrome

Fsp

Spastic Paraplegia, Familial

Spastic Paraplegia Hereditary

Spastic Paraplegia 3, Autosomal Dominant

Spastic Paraparesis

Hereditary Spastic Paralysis

Familial Spastic Paralysis

Hereditary Spastic Ataxia

疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

直系同源

种属 基因名 来源 基因 ID
Felis catus ATG9A VGNC VGNC:80143
Macaca mulatta ATG9A VGNC VGNC:81180
Canis familiaris ATG9A VGNC VGNC:38228
Rattus norvegicus ATG9A RGD RGD:1310450
Mus musculus ATG9A MGD MGI:2138446
Bos taurus ATG9A VGNC VGNC:26262