2. Gene
  3. Hpgd - 15-hydroxyprostaglandin dehydrogenase Gene

Hpgd - 15-hydroxyprostaglandin dehydrogenase Gene

  • 基因
  • 蛋白
  • 相关产品
  • 直系同源

中文名称：15-羟基前列腺素脱氢酶

种属: Rattus norvegicus

基因 ID: 79242 | 基因类型: protein coding

关于 Hpgd

Primary_assembly 16: 33,986,266-34,024,228 reverse strand.mRatBN7.2:CM026989.1

This gene has 1 transcript (splice variant), 204 orthologues and is associated with 16 phenotypes. Biased expression in Lung (RPKM 31.9), Kidney (RPKM 262.4) and 5 other tissues.

功能概要

该基因编码的蛋白可启动 15-羟基前列腺素脱氢酶 (NAD+) 活性和相同的蛋白质结合活性。参与多个过程，包括血管相关平滑肌细胞增殖的正调节；前列腺素代谢过程；和凝血酶激活受体信号通路。位于细胞质和细胞外空间。用于研究癌症。消化性溃疡病的生物标志物。该基因的人类直系同源物与结肠癌和原发性肥大性骨关节病有关。与人 HPGD（15-羟基前列腺素脱氢酶）同源。 [由基因组资源联盟提供，2022 年 4 月]

Enables 15-hydroxyprostaglandin dehydrogenase (NAD+) activity and identical protein binding activity. Involved in several processes, including positive regulation of vascular associated smooth muscle cell proliferation; prostaglandin metabolic process; and thrombin-activated receptor signaling pathway. Located in cytoplasm and extracellular space. Used to study carcinoma. Biomarker of peptic ulcer disease. Human ortholog(s) of this gene implicated in colon carcinoma and primary hypertrophic osteoarthropathy. Orthologous to human HPGD (15-hydroxyprostaglandin dehydrogenase). [provided by Alliance of Genome Resources, Apr 2022]

Hpgd 基因产物(1)

mRNA Protein Name
NM_024390.3 NP_077366.2 15-hydroxyprostaglandin dehydrogenase [NAD(+)]
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables 15-hydroxyprostaglandin dehydrogenase (NAD+) activity IDA
IDA: 通过直接分析推断
9099857 RGD
enables identical protein binding IPI
IPI: 通过物理相互作用推断
2251293 RGD
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in female pregnancy IEP
IEP: 通过表达模式推断
3338612 RGD
involved in kidney development IEP
IEP: 通过表达模式推断
24647712 RGD
involved in positive regulation of apoptotic process IDA
IDA: 通过直接分析推断
22580984 RGD
involved in positive regulation of vascular associated smooth muscle cell proliferation IMP
IMP: 通过突变表型推断
24657469 RGD
involved in prostaglandin metabolic process IDA
IDA: 通过直接分析推断
18058808 RGD
involved in response to estradiol IEP
IEP: 通过表达模式推断
3478736 RGD
involved in response to ethanol IDA
IDA: 通过直接分析推断
6574558 RGD
involved in response to lipopolysaccharide IEP
IEP: 通过表达模式推断
12399253 RGD
involved in thrombin-activated receptor signaling pathway IEP
IEP: 通过表达模式推断
19383433 RGD
细胞组分 GO 注释 逻辑证据 参考文献 来源
located in extracellular space IDA
IDA: 通过直接分析推断
24647712 RGD
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

Hpgd 蛋白结构

ADH_SDR_c_like

ADH_SDR_c_like: cd05323 (5 - 253)

  • 0
  • 100
  • 200
  • 266 a.a.
蛋白主名 其他名称

15-hydroxyprostaglandin dehydrogenase [NAD(+)]

15-PGDH

NAD-dependent 15-hydroxyprostaglandin dehydrogenase

PGDH

eicosanoid/docosanoid dehydrogenase

hydroxyprostaglandin dehydrogenase 15 (NAD)

prostaglandin dehydrogenase 1

相关产品

Pre-clinical Phase
生物活性分子 (16)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-108259 HQL-79 Inhibitor 99.89% 否
HY-110167 TFC 007 Inhibitor 98.01% 否
HY-12791 hPGDS-IN-1 Inhibitor 99.92% 否
HY-10439 HPGDS inhibitor 1 Inhibitor 99.04% 否
HY-109134 Pizuglanstat Inhibitor 99.70% 否
HY-139972 PROTAC(H-PGDS)-7 99.42% 否
HY-126134 HPGDS inhibitor 2 Inhibitor 99.72% 否
HY-146662 HPGDS inhibitor 3 Inhibitor / 否
HY-157577 PROTAC(H-PGDS)-8 Degrader / 否
HY-RS06338 HPGD Human Pre-designed siRNA Set A Pre-designed Sets / 否
HY-RS06339 Hpgd Mouse Pre-designed siRNA Set A Pre-designed Sets / 否
HY-RS06340 Hpgd Rat Pre-designed siRNA Set A Pre-designed Sets / 否
HY-RS06341 HPGDS Human Pre-designed siRNA Set A Pre-designed Sets / 否
HY-109134A Pizuglanstat hydrate Inhibitor / 否
HY-120581 ML388 Inhibitor / 否
HY-139171 F092 Inhibitor 99.79% 否

直系同源

种属 基因名 来源 基因 ID
Homo sapiens Hpgd NCBI NCBI:3248
Mus musculus Hpgd NCBI NCBI:15446
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