1. Gene
  2. PEAK1 - pseudopodium enriched atypical kinase 1 Gene

PEAK1 - pseudopodium enriched atypical kinase 1 Gene

中文名称:伪足富非典型激酶 1

种属: Homo sapiens

同用名: SGK269

基因 ID: 79834 | 基因类型: protein coding

关于 PEAK1

Cytogenetic location: 15q24.3 Genomic coordinates (GRCh38): 15:77,100,654-77,420,914 (from NCBI)

This gene has 13 transcripts (splice variants), 217 orthologues and 3 paralogues. Ubiquitous expression in spleen (RPKM 15.5), lung (RPKM 8.0) and 23 other tissues.

功能概要

该基因编码一种非受体酪氨酸激酶,它是新激酶家族三 (NFK3) 家族的成员。在迁移细胞中,编码的蛋白质与肌动蛋白细胞骨架和粘着斑相关,并促进发展粘着斑伸长。该蛋白可能在细胞迁移、增殖和癌症转移的调节中发挥作用。[RefSeq 提供,2014 年 3 月]

This gene encodes a non-receptor tyrosine kinase that is a member of the new kinase family three (NFK3) family. In migrating cells, the encoded protein is associated with the actin Cytoskeleton and focal adhesions and promotes developing focal adhesion elongation. This protein may play a role in the regulation of cell migration, proliferation and Cancer metastasis. [provided by RefSeq, Mar 2014]

PEAK1 基因产物(5)

mRNA Protein Name
NM_001385026.1 NP_001371955.1 inactive tyrosine-protein kinase PEAK1 isoform a
NM_001385027.1 NP_001371956.1 inactive tyrosine-protein kinase PEAK1 isoform b
NM_001387085.1 NP_001374014.1 inactive tyrosine-protein kinase PEAK1 isoform a
NM_001387086.1 NP_001374015.1 inactive tyrosine-protein kinase PEAK1 isoform a
NM_024776.5 NP_079052.2 inactive tyrosine-protein kinase PEAK1 isoform a
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
NOT enables ATP binding IDA
IDA: 通过直接分析推断
24107129 GOA
enables identical protein binding IDA
IDA: 通过直接分析推断
29212708 GOA
enables non-membrane spanning protein tyrosine kinase activity IDA
IDA: 通过直接分析推断
20534451 GOA
enables protein binding IPI
IPI: 通过物理相互作用推断
20534451 GOA
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in cell migration IDA
IDA: 通过直接分析推断
20534451 GOA
involved in cell migration IMP
IMP: 通过突变表型推断
23105102 GOA
involved in focal adhesion assembly IMP
IMP: 通过突变表型推断
23105102 GOA
involved in protein autophosphorylation IDA
IDA: 通过直接分析推断
20534451 GOA
involved in regulation of focal adhesion assembly IDA
IDA: 通过直接分析推断
23105102 GOA
involved in substrate adhesion-dependent cell spreading IDA
IDA: 通过直接分析推断
20534451 GOA
细胞组分 GO 注释 逻辑证据 参考文献 来源
located in actin cytoskeleton IDA
IDA: 通过直接分析推断
20534451 GOA
located in focal adhesion IDA
IDA: 通过直接分析推断
20534451 GOA
EXP:通过实验结果推断 IDA:通过直接分析推断 IPI:通过物理相互作用推断 IMP:通过突变表型推断 IGI:通过遗传相互作用推断 IEP:通过表达模式推断

PEAK1 蛋白结构

Pkinase

Pkinase: Protein kinase domain (1456 - 1659)

  • 0
  • 300
  • 600
  • 900
  • 1200
  • 1500
  • 1746 a.a.
蛋白主名 其他名称

inactive tyrosine-protein kinase PEAK1

NKF3 kinase family member

PEAK1 蛋白互作信息

分类
蛋白名称 蛋白编号 互作蛋白 互作蛋白种属 互作蛋白编号 实验方法 参考文献
种属内
PEAK1 Q9H792 BCAR1 Homo sapiens P56945 20534451
种属间: 跨种属相互作用 种属内: 同种属相互作用

直系同源

种属 基因名 来源 基因 ID
Felis catus PEAK1 VGNC VGNC:64107
Rattus norvegicus PEAK1 RGD RGD:1312026
Canis familiaris PEAK1 VGNC VGNC:44407
Mus musculus PEAK1 MGD MGI:2442366
Macaca mulatta PEAK1 VGNC VGNC:84419
Bos taurus PEAK1 VGNC VGNC:32733
Others PEAK1 NCBI