2. Gene
  3. CENPT - centromere protein T Gene

CENPT - centromere protein T Gene

  • 基因
  • 蛋白
  • 疾病
  • 相关产品
  • 直系同源

中文名称：着丝粒蛋白 T

种属: Homo sapiens

同用名: SSMGA; CENP-T; C16orf56

基因 ID: 80152 | 基因类型: protein coding

关于 CENPT

Cytogenetic location: 16q22.1 Genomic coordinates (GRCh38): 16:67,828,157-67,847,693 (from NCBI)

This gene has 35 transcripts (splice variants), 176 orthologues and is associated with 1 phenotype. Ubiquitous expression in skin (RPKM 26.3), testis (RPKM 20.1) and 25 other tissues.

功能概要

着丝粒是一个专门的染色质结构域，存在于整个细胞周期中，它作为一个平台，在有丝分裂期间发生着丝粒的瞬时组装。所有活性着丝粒的特点是存在长阵列的核小体，其中 CENPA (MIM 117139) 取代了组蛋白 H3 (参见 MIM 601128) 。 CENPT 是着丝粒组装所需的附加因子 (Foltz 等人，2006 [PubMed 16622419]) 。[OMIM 提供，2008 年 3 月]

The centromere is a specialized chromatin domain, present throughout the cell cycle, that acts as a platform on which the transient assembly of the kinetochore occurs during mitosis. All active centromeres are characterized by the presence of long arrays of nucleosomes in which CENPA (MIM 117139) replaces histone H3 (see MIM 601128). CENPT is an additional factor required for centromere assembly (Foltz et al., 2006 [PubMed 16622419]).[supplied by OMIM, Mar 2008]

CENPT 基因产物(1)

mRNA Protein Name
NM_025082.4 NP_079358.3 centromere protein T
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables protein binding IPI
IPI: 通过物理相互作用推断
19070575 GOA
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in chromosome organization IMP
IMP: 通过突变表型推断
21695110 GOA
involved in chromosome segregation IMP
IMP: 通过突变表型推断
21529714 GOA
involved in kinetochore assembly IMP
IMP: 通过突变表型推断
21529714 GOA
involved in mitotic cell cycle IMP
IMP: 通过突变表型推断
21695110 GOA
细胞组分 GO 注释 逻辑证据 参考文献 来源
located in chromosome, centromeric region IDA
IDA: 通过直接分析推断
21695110 GOA
part of inner kinetochore IPI
IPI: 通过物理相互作用推断
36085283 GOA
located in kinetochore IDA
IDA: 通过直接分析推断
21529714 GOA
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

CENPT 蛋白结构

CENP-T_C

CENP-T_C: Centromere kinetochore component CENP-T histone fold (25 - 514)

  • 0
  • 100
  • 200
  • 300
  • 400
  • 500
  • 561 a.a.
蛋白主名 其他名称

centromere protein T

interphase centromere complex protein 22

CENPT 蛋白互作信息

分类
蛋白名称 蛋白编号 互作蛋白 互作蛋白种属 互作蛋白编号 实验方法 参考文献
种属内
CENPT Q96BT3 CENPW Homo sapiens Q5EE01
Pull Down
19533040
种属间: 跨种属相互作用 种属内: 同种属相互作用

关联疾病

疾病名称 别名
Short Stature And Microcephaly With Genital Anomalies

SSMGA
Methylmalonic Aciduria And Homocystinuria, Cblx Type

Mental Retardation, X-Linked 3

Methylmalonic Acidemia With Homocystinuria, Type Cblx

MAHCX

Intellectual Developmental Disorder, X-Linked 3

Xlid3

Mrx3

Methylmalonic Acidemia And Homocysteinemia Cblx Type

Combined Defect In Adenosylcobalamin And Methylcobalamin Synthesis, Type Cblx

Methylmalonic Aciduria With Homocystinuria, Type Cblx

Methylmalonic Acidemia And Homocysteinemia, Cblx Type

Methylmalonic Aciduria And Homocysteinemia, Cblx Type

Methylmalonic Aciduria And Homocysteinemia , Cblx Type

Mental Retardation, X-Linked, Type 3
Microcephaly

Microencephaly

Microcephalus

Microcephalic

Nanocephaly

Congenital Microcephaly

Brain Hypoplasia

Brain Nondevelopment

Cephalic Hypoplasia

Undeveloped Cerebrum

Undeveloped Brain

Micrencephalon

Micrencephaly
疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

相关产品

Pre-clinical Phase
生物活性分子 (1)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-RS02491 CENPT Human Pre-designed siRNA Set A Pre-designed Sets / 否

直系同源

种属 基因名 来源 基因 ID
Mus musculus CENPT MGD MGI:2443939
Rattus norvegicus CENPT RGD RGD:1309383
Macaca mulatta CENPT VGNC VGNC:71103
Felis catus CENPT VGNC VGNC:60761
Bos taurus CENPT VGNC VGNC:27185
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