1. Gene
  2. CENPW - centromere protein W Gene

CENPW - centromere protein W Gene

中文名称:着丝粒蛋白 W

种属: Homo sapiens

同用名: CUG2; CENP-W; C6orf173

基因 ID: 387103 | 基因类型: protein coding

关于 CENPW

Cytogenetic location: 6q22.32 Genomic coordinates (GRCh38): 6:126,340,115-126,483,320 (from NCBI)

This gene has 3 transcripts (splice variants) and 124 orthologues. Broad expression in bone marrow (RPKM 2.8), testis (RPKM 2.0) and 20 other tissues.

功能概要

预测可实现 DNA 结合活性和蛋白质异二聚化活性。参与染色体分离;着丝粒组装;和有丝分裂细胞周期。位于着丝粒和核质中。 [由基因组资源联盟提供,2022 年 4 月]

Predicted to enable DNA binding activity and protein heterodimerization activity. Involved in chromosome segregation; kinetochore assembly; and mitotic cell cycle. Located in kinetochore and nucleoplasm. [provided by Alliance of Genome Resources, Apr 2022]

CENPW 基因产物(3)

mRNA Protein Name
NM_001012507.4 NP_001012525.1 centromere protein W isoform b
NM_001286524.2 NP_001273453.1 centromere protein W isoform a
NM_001286525.2 NP_001273454.1 centromere protein W isoform c
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables protein binding IPI
IPI: 通过物理相互作用推断
19070575 GOA
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in chromosome organization IMP
IMP: 通过突变表型推断
21695110 GOA
involved in chromosome segregation IMP
IMP: 通过突变表型推断
21695110 GOA
involved in kinetochore assembly IMP
IMP: 通过突变表型推断
21695110 GOA
involved in mitotic cell cycle IMP
IMP: 通过突变表型推断
21695110 GOA
细胞组分 GO 注释 逻辑证据 参考文献 来源
located in chromosome, centromeric region IDA
IDA: 通过直接分析推断
19533040 GOA
part of inner kinetochore IPI
IPI: 通过物理相互作用推断
36085283 GOA
located in kinetochore IDA
IDA: 通过直接分析推断
21695110 GOA
EXP:通过实验结果推断 IDA:通过直接分析推断 IPI:通过物理相互作用推断 IMP:通过突变表型推断 IGI:通过遗传相互作用推断 IEP:通过表达模式推断

CENPW 蛋白结构

CENP-W

CENP-W: CENP-W protein (1 - 88)

  • 0
  • 88 a.a.
蛋白主名 其他名称

centromere protein W

cancer-up-regulated gene 2 protein

CENPW 蛋白互作信息

分类
蛋白名称 蛋白编号 互作蛋白 互作蛋白种属 互作蛋白编号 实验方法 参考文献
种属内
CENPW Q5EE01 CENPT Homo sapiens Q96BT3 19533040
种属内
CENPW Q5EE01 CENPT Homo sapiens Q96BT3 33961781
种属内
CENPW Q5EE01 CENPT Homo sapiens Q96BT3
Y2H
19533040
种属内
CENPW Q5EE01 CENPT Homo sapiens Q96BT3
GMS
22304917
种属内
CENPW Q5EE01 CENPT Homo sapiens Q96BT3 19533040
种属间: 跨种属相互作用 种属内: 同种属相互作用

关联疾病

疾病名称 别名
Acromesomelic Dysplasia 2b

Fibular Hypoplasia And Complex Brachydactyly

Du Pan Syndrome

AMD2B

Dupans

Acromesomelic Dysplasia-2b

Fibular Aplasia-Complex Brachydactyly Syndrome

疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

直系同源

种属 基因名 来源 基因 ID
Felis catus CENPW VGNC VGNC:60763
Mus musculus CENPW MGD MGI:1913561
Rattus norvegicus CENPW RGD RGD:1593465
Canis familiaris CENPW VGNC VGNC:39114
Bos taurus CENPW VGNC VGNC:27187
Macaca mulatta CENPW VGNC VGNC:71071