KCNIP4 - potassium voltage-gated channel interacting protein 4 Gene

中文名称：钾电压门控通道相互作用蛋白 4

种属: Homo sapiens

同用名: CALP; KCHIP4

关于 KCNIP4

功能概要

该基因编码电压门控钾 (Kv) 通道相互作用蛋白 (KCNIP) 家族的成员，属于 EF 手超家族的恢复蛋白分支。 KCNIP 家族的成员是小的钙结合蛋白。它们都具有 EF-hand-like 结构域，并且在 N 端彼此不同。它们是原生 Kv4 通道复合体的组成部分。它们可以调节 A 型电流，从而调节神经元兴奋性，以响应细胞内钙的变化。该蛋白质成员还与早老素相互作用。已经为该基因鉴定了编码不同同种型的多个选择性剪接的转录物变体。[RefSeq 提供，2008 年 7 月]

This gene encodes a member of the family of voltage-gated potassium (Kv) channel-interacting proteins (KCNIPs), which belong to the recoverin branch of the EF-hand superfamily. Members of the KCNIP family are small calcium binding proteins. They all have EF-hand-like domains, and differ from each other in the N-terminus. They are integral subunit components of native Kv4 channel complexes. They may regulate A-type currents, and hence neuronal excitability, in response to changes in intracellular calcium. This protein member also interacts with presenilin. Multiple alternatively spliced transcript variants encoding distinct isoforms have been identified for this gene. [provided by RefSeq, Jul 2008]