CSRP3 - cysteine and glycine rich protein 3 Gene

中文名称：富半胱氨酸和甘氨酸的蛋白质 3

种属: Homo sapiens

同用名: CLP; MLP; CRP3; LMO4; CMD1M; CMH12

基因 ID: 8048 | 基因类型: protein coding

关于 CSRP3

Cytogenetic location: 11p15.1 Genomic coordinates (GRCh38): 11:19,182,030-19,201,983 (from NCBI)

This gene has 6 transcripts (splice variants), 201 orthologues, 2 paralogues and is associated with 4 phenotypes. Restricted expression toward heart (RPKM 715.6).

功能概要

该基因编码 LIM 域蛋白的 CSRP 家族成员，可能参与对发育和细胞分化很重要的调节过程。在该蛋白质中发现的 LIM/双锌指基序存在于一组在基因调控、细胞生长和体细胞分化中具有关键功能的蛋白质中。该基因的突变被认为会导致人类肥厚型心肌病 (HCM) 和扩张型心肌病 (DCM) 的遗传形式。已经发现该基因具有不同 5' UTR 但编码相同蛋白质的选择性剪接转录变体。[RefSeq 提供，2008 年 7 月]

This gene encodes a member of the CSRP family of LIM domain proteins, which may be involved in regulatory processes important for development and cellular differentiation. The LIM/double zinc-finger motif found in this protein is found in a group of proteins with critical functions in gene regulation, cell growth, and somatic differentiation. Mutations in this gene are thought to cause heritable forms of hypertrophic cardiomyopathy (HCM) and dilated cardiomyopathy (DCM) in humans. Alternatively spliced transcript variants with different 5' UTR, but encoding the same protein, have been found for this gene. [provided by RefSeq, Jul 2008]

CSRP3 基因产物(2)

mRNA	Protein	Name
NM_001369404.1	NP_001356333.1	cysteine and glycine-rich protein 3 isoform 2
NM_003476.5	NP_003467.1	cysteine and glycine-rich protein 3 isoform 1

CSRP3 蛋白结构

LIM

0
100
194 a.a.

蛋白主名

其他名称

cysteine and glycine-rich protein 3

LIM domain only 4

CSRP3 蛋白互作信息

分类	蛋白名称	蛋白编号	互作蛋白	互作蛋白种属	互作蛋白编号	实验方法	参考文献
种属内	CSRP3	P50461	CFL2	Homo sapiens	Q9Y281	Far-WB	24860983
种属内	CSRP3	P50461	GNB2	Homo sapiens	P62879	Anti Tag CoIP	33961781
种属内	CSRP3	P50461	ACTN2	Homo sapiens	P35609	Pull Down	24860983
种属内	CSRP3	P50461	TCAP	Homo sapiens	O15273	Y2H	15582318
种属内	CSRP3	P50461	ACTN2	Homo sapiens	P35609	Anti Bait CoIP	15205937
种属内	CSRP3	P50461	TCAP	Homo sapiens	O15273	Pull Down	15582318
种属内	CSRP3	P50461	SMPDL3B	Homo sapiens	Q92485	Anti Tag CoIP	33961781
种属内	CSRP3	P50461	NRAP	Homo sapiens	Q86VF7	Filter Binding	15205937
种属内	CSRP3	P50461	CSRP3	Homo sapiens	P50461	Far-WB	24860983
种属内	CSRP3	P50461	NME2	Homo sapiens	P22392	Anti Tag CoIP	33961781
种属内	CSRP3	P50461	XPNPEP1	Homo sapiens	Q9NQW7	Anti Tag CoIP	33961781
种属内	CSRP3	P50461	RIN3	Homo sapiens	Q8TB24	Y2H Array	25814554
种属内	CSRP3	P50461	MYOD1	Homo sapiens	P15172	Far-WB	24860983
种属内	CSRP3	P50461	TCAP	Homo sapiens	O15273	Pull Down	24860983

种属间: 跨种属相互作用 种属内: 同种属相互作用

关联疾病

疾病名称

别名

Cardiomyopathy, Familial Hypertrophic, 12

Hypertrophic Cardiomyopathy 12	CMH12
Cardiomyopathy, Hypertrophic, 12	Cardiomyopathy Familial Hypertrophic 12
Cardiomyopathy, Familial Hypertrophic 12	Cardiomyopathy, Hypertrophic, Familial, Type 12

Cardiomyopathy, Dilated, 1m

Dilated Cardiomyopathy 1m	CMD1M
Cardiomyopathy, Dilated 1m	Cardiomyopathy, Dilated, Type 1m

Dilated Cardiomyopathy

Familial Dilated Cardiomyopathy	Primary Dilated Cardiomyopathy
Idiopathic Dilated Cardiomyopathy	Congestive Cardiomyopathy
Idiopathic Dilation Cardiomyopathy	Primary Familial Dilated Cardiomyopathy
Cardiomyopathy, Dilated	DCM
Cardiomyopathy, Familial Dilated	Dilated Cardiomyopathy, Familial
Hypokinetic Dilated Cardiomyopathy, Familial	Familial Idiopathic Cardiomyopathy
Fdc	Cardiomyopathy, Familial Idiopathic
Idiopathic Cardiomegaly	Dilated Congestive Cardiomyopathy
Chronic Dilated Cardiomyopathy	Ccm - [Congestive Cardiomyopathy]
Cocm - [Congestive Cardiomyopathy]	Dcm - [Dilated Cardiomyopathy]
Dilated-Hypokinetic Cardiomyopathy	Congestive Idiopathic Cardiomyopathy
Primary Idiopathic Dilated Cardiomyopathy

Familial Isolated Dilated Cardiomyopathy

Familial Or Idiopathic Dilated Cardiomyopathy

Hypertrophic Cardiomyopathy

Hypertrophic Obstructive Cardiomyopathy	Cardiomyopathy, Hypertrophic
Cardiomyopathy Hypertrophic Obstructive	Cardiomyopathy, Hypertrophic, Familial
Idiopathic Myocardial Hypertrophy	Idiopathic Hypertrophic Cardiomyopathy
Obstructive Idiopathic Hypertrophic Cardiomyopathy	Obstructive Cardiomyopathy
Idiopathic Hypertrophic Subaortic Stenosis	Muscular Subaortic Stenosis
Hypertrophic Obstructive Subaortic Stenosis

Endocardial Fibroelastosis

Endomyocardial Fibroelastosis	Elastomyofibrosis
EFE	Efe - [Endocardial Fibroelastosis]
Primary Endocardial Fibroelastosis	Fibroelastosis Cordis
Fetal Endocarditis	Fibroelastosis
Congenital Endocardial Fibroelastosis	Congenital Valvular Endocarditis

Limb-Girdle Muscular Dystrophy

Lgmd	Limb Girdle Muscular Dystrophy
Muscular Dystrophies, Limb-Girdle	Erb'S Muscular Dystrophy
Leyden-Mbius Muscular Dystrophy	Limb-Girdle Syndrome
Myopathic Limb-Girdle Syndrome	Limb Girdle
Muscular Dystrophy Limb-Girdle	Dystrophy, Muscular, Limb-Girdle
Lgmd - [Limb-Girdle Muscular Dystrophy]	Limb Girdle Muscle Dystrophy
Limb-Girdle Myopathy

Cardiomyopathy, Familial Hypertrophic, 7

Hypertrophic Cardiomyopathy 7	CMH7
Cardiomyopathy, Familial Hypertrophic 7	Cardiomyopathy, Hypertrophic, 7
Cardiomyopathy, Hypertrophic, Familial, Type 7

Autosomal Recessive Limb-Girdle Muscular Dystrophy Type 2g

Lgmd2g	Limb-Girdle Muscular Dystrophy Due To Telethonin Deficiency
Muscular Dystrophy, Limb-Girdle, Type 2g

Intrinsic Cardiomyopathy

Heart Disease

Heart Failure	Congenital Heart Disease
Heart Diseases	Congenital Heart Defects
Congenital Heart Defect	Heart Malformation
Congenital Anomaly Of Heart	Heart Defect
Heart-Congenital Defect	Congenital Heart Disorder
Heart Defects Congenital	Heart Defects, Congenital
Heart Defects	Heart Disease, Congenital
Disease, Heart, Congenital	Congestive Heart Failure

Familial Isolated Hypoparathyroidism

Fih

Left Ventricular Noncompaction

Noncompaction Cardiomyopathy	Left Ventricular Hypertrabeculation
Lvnc	Spongy Myocardium
Isolated Noncompaction Of The Ventricular Myocardium	Left Ventricular Myocardial Noncompaction Cardiomyopathy
Fetal Myocardium	Honeycomb Myocardium
Hypertrabeculation Syndrome	Left Ventricular Non-Compaction
Lvht	Non-Compaction Of The Left Ventricular Myocardium
Ventricular Noncompaction, Left	Non-Compaction Cardiomyopathy

Muscular Dystrophy

Muscular Dystrophies	Congenital Md
Congenital Muscular Dystrophy	Cmd
Mdc	Dystrophy, Muscular
Gower'S Muscular Dystrophy	Progressive Musclular Dystrophy
Pseudohypertrophic Atrophy	Pseudohypertrophic Muscle Paralysis
Pseudohypertrophic Muscular Atrophy	Pseudohypertrophic Muscular Dystrophy
Pseudohypertrophic Paralysis	Pseudomuscular Hypertrophy

Myofibrillar Myopathy

Desmin Related Myopathy	Myotilinopathy
Myopathy, Myofibrillar	Alpha Beta Crystallinopathy
Desmin Storage Myopathy	Desminopathy
Filaminopathy	Protein Surplus Myopathy
Zaspopathy	Myofibrillar Myopathies
Myopathy, Myofibrillar, Desmin-Related	Myopathy, Desmin Storage
Mfm - [Myofibrillar Myopathy]

Restrictive Cardiomyopathy

Familial Restrictive Cardiomyopathy	Cardiomyopathy, Restrictive
Cardiomyopathy, Constrictive	Primary Restrictive Cardiomyopathy
Rcm	Cardiomyopathy Restrictive

Cardiomyopathy, Familial Hypertrophic, 1

Asymmetric Septal Hypertrophy	Familial Hypertrophic Cardiomyopathy
Hypertrophic Cardiomyopathy 1	CMH1
Hypertrophic Cardiomyopathy 19	CMH
Ventricular Hypertrophy, Hereditary	Ash
Hypertrophic Subaortic Stenosis, Idiopathic	Cardiomyopathy, Familial Hypertrophic
Cardiomyopathy, Hypertrophic, 1, Digenic	Cardiomyopathy, Familial Hypertrophic 1
Hcm	Hereditary Ventricular Hypertrophy
Idiopathic Hypertrophic Subaortic Stenosis	Hypertrophic Cardiomyopathy
Cardiomyopathy, Hypertrophic, Familial	Cardiomyopathy, Hypertrophic, 1
Familial Asymmetric Septal Hypertrophy	Heritable Hypertrophic Cardiomyopathy
Fhc	Cardiomyopathy, Hypertrophic, Familial, Type 1

Lipoprotein Quantitative Trait Locus

Coronary Artery Disease	Coronary Artery Anomaly
Coronary Artery Disease, Susceptibility To	Myocardial Ischemia
Congenital Anomaly Of Coronary Artery	Coronary Arteriosclerosis
Coronary Disease	Coronary Heart Disease
Coronary Artery Disorder	LPAQTL
Lpa Deficiency, Congenital	Coronary Artery Abnormality
Coronary Artery Anomaly, Congenital	Chd
Coronary Syndrome	Congenital Malformations Of Coronary Vessels
Malformation Of Coronary Vessels	Congenital Coronary Artery Anomaly
Congenital Coronary Artery Deformity	Congenital Coronary Artery Disorder
Abnormal Coronary Artery	Congenital Coronary Artery Malposition
Congenital Coronary Disease	Congenital Anomaly Of Coronary Arteries

Brugada Syndrome

Sudden Unexpected Nocturnal Death Syndrome	Sudden Unexplained Nocturnal Death Syndrome
Bangungut	Brugada Type Idiopathic Ventricular Fibrillation
Pokkuri Death Syndrome	Sunds
Idiopathic Ventricular Fibrillation, Brugada Type	Sudden Unexplained Death
Dream Disease	Right Bundle Branch Block, St Segment Elevation, And Sudden Death Syndrome
Sudden Unexplained Death Syndrome	Suds
Sunds - [Sudden Unexplained Nocturnal Death Syndrome]

Familial Atrial Fibrillation

Atrial Fibrillation, Familial	Atfb
Atrial Fibrillation Autosomal Dominant	Autosomal Dominant Atrial Fibrillation
Auricular Fibrillation	Atrial Fibrillation
Atrial Fibrillation, Familial, 1

疾病名称	别名
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Cat. No.	产品名	作用方式	纯度	是否罕见病
HY-RS03260	CSRP3 Human Pre-designed siRNA Set A	Pre-designed Sets	/	否

直系同源

种属	基因名	来源	基因 ID
Rattus norvegicus	CSRP3	RGD	RGD:71092
Mus musculus	CSRP3	MGD	MGI:1330824
Felis catus	CSRP3	VGNC	VGNC:61234
Macaca mulatta	CSRP3	VGNC	VGNC:71529
Bos taurus	CSRP3	VGNC	VGNC:27775
Canis familiaris	CSRP3	VGNC	VGNC:39676

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