PTP4A2 - protein tyrosine phosphatase 4A2 Gene

中文名称：蛋白酪氨酸磷酸酶 4A2

种属: Homo sapiens

同用名: HH13; OV-1; PRL2; HH7-2; PRL-2; PTP4A; HU-PP-1; PTPCAAX2; ptp-IV1a; ptp-IV1b

关于 PTP4A2

功能概要

该基因编码的蛋白质属于蛋白酪氨酸磷酸酶 (PTP) 家族的一小类。 PTP 是细胞信号分子，在各种细胞过程中发挥调节作用。此类 PTP 包含蛋白酪氨酸磷酸酶催化结构域和特征性 C 末端异戊二烯基化基序。该 PTP 已被证明主要通过其 C 末端异戊二烯化与质膜和内体膜相关联。发现此 PTP 与 Rab 香叶基香叶基转移酶 II (β GGT II) 的 β 亚基相互作用，因此可能作为 GGT II 活性的调节剂发挥作用。该基因在哺乳动物细胞中的过度表达赋予了转化的表型，这表明它在肿瘤发生中的作用。已经描述了选择性剪接的转录物变体。相关假基因存在于 11、12 和 17 号染色体上。[RefSeq 提供，2010 年 8 月]

The protein encoded by this gene belongs to a small class of the protein tyrosine Phosphatase (PTP) family. PTPs are cell signaling molecules that play regulatory roles in a variety of cellular processes. PTPs in this class contain a protein tyrosine Phosphatase catalytic domain and a characteristic C-terminal prenylation motif. This PTP has been shown to primarily associate with plasmic and endosomal membrane through its C-terminal prenylation. This PTP was found to interact with the beta-subunit of Rab geranylgeranyltransferase II (beta GGT II), and thus may function as a regulator of GGT II activity. Overexpression of this gene in mammalian cells conferred a transformed phenotype, which suggested its role in tumorigenesis. Alternatively spliced transcript variants have been described. Related pseudogenes exist on chromosomes 11, 12 and 17. [provided by RefSeq, Aug 2010]