FAM83D - family with sequence similarity 83 member D Gene

中文名称：具有序列相似性的家族 83 成员 D

种属: Homo sapiens

同用名: CHICA; C20orf129; dJ616B8.3

基因 ID: 81610 | 基因类型: protein coding

关于 FAM83D

Cytogenetic location: 20q11.23 Genomic coordinates (GRCh38): 20:38,926,417-38,953,106 (from NCBI)

This gene has 2 transcripts (splice variants), 209 orthologues and 7 paralogues. Biased expression in esophagus (RPKM 30.9), urinary bladder (RPKM 8.3) and 13 other tissues.

功能概要

启用驱动蛋白结合活动；微管结合活性；和蛋白激酶结合活性。参与多个过程，包括细胞周期 G1/S 相变的正调控；蛋白质定位到有丝分裂纺锤体；和细胞内信号转导的调节。位于胞质溶胶中；细胞间桥；和有丝分裂纺锤体极。 [由基因组资源联盟提供，2022 年 4 月]

Enables Kinesin binding activity; microtubule binding activity; and protein kinase binding activity. Involved in several processes, including positive regulation of cell cycle G1/S phase transition; protein localization to mitotic spindle; and regulation of intracellular signal transduction. Located in cytosol; intercellular bridge; and mitotic spindle pole. [provided by Alliance of Genome Resources, Apr 2022]

FAM83D 基因产物(1)

mRNA	Protein	Name
NM_030919.3	NP_112181.3	protein FAM83D

基因本体论

分子功能
生物过程
细胞组分

分子功能 GO 注释	逻辑证据	参考文献	来源
enables kinesin binding	IPI IPI: 通过物理相互作用推断	18485706	GOA
enables microtubule binding	IDA IDA: 通过直接分析推断	18485706	GOA
enables protein binding	IPI IPI: 通过物理相互作用推断	21900206	GOA
enables protein kinase binding	IPI IPI: 通过物理相互作用推断	24736947	GOA

生物过程 GO 注释	逻辑证据	参考文献	来源
involved in cell migration	IDA IDA: 通过直接分析推断	24344117	GOA
involved in cell population proliferation	IDA IDA: 通过直接分析推断	24344117	GOA
involved in epithelial to mesenchymal transition	IDA IDA: 通过直接分析推断	24344117	GOA
involved in metaphase chromosome alignment	IMP IMP: 通过突变表型推断	18485706	GOA
involved in positive regulation of cell cycle G1/S phase transition	IMP IMP: 通过突变表型推断	25646692	GOA
involved in protein localization to mitotic spindle	IMP IMP: 通过突变表型推断	18485706	GOA
involved in regulation of ERK1 and ERK2 cascade	IMP IMP: 通过突变表型推断	24736947	GOA
involved in regulation of TOR signaling	IDA IDA: 通过直接分析推断	24344117	GOA
involved in regulation of protein catabolic process	IDA IDA: 通过直接分析推断	24344117	GOA

细胞组分 GO 注释	逻辑证据	参考文献	来源
located in cytoplasm	IDA IDA: 通过直接分析推断	18445686	GOA
located in mitotic spindle pole	IDA IDA: 通过直接分析推断	15561729	GOA
located in spindle	IDA IDA: 通过直接分析推断	18445686	GOA

EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

FAM83D 蛋白结构

DUF1669

0
100
200
300
400
500
615 a.a.

蛋白主名

其他名称

protein FAM83D

spindle protein CHICA

FAM83D 蛋白互作信息

分类	蛋白名称	蛋白编号	互作蛋白	互作蛋白种属	互作蛋白编号	实验方法	参考文献
Intra	FAM83D	Q9H4H8	CSNK1A1	Homo sapiens	P48729	Anti Tag CoIP	29789297
Intra	FAM83D	Q9H4H8	HMMR	Homo sapiens	O75330	Anti Tag CoIP	29789297

种属间: 跨种属相互作用 种属内: 同种属相互作用

关联疾病

疾病名称

别名

Amelogenesis Imperfecta, Type Iiia

Ai3	Adhcai
Amelogenesis Imperfecta Type 3	AI3A
Amelogenesis Imperfecta, Type Iii	Amelogenesis Imperfecta, Hypocalcification Type, Autosomal Dominant
Amelogenesis Imperfecta Type 3a	Amelogenesis Imperfecta Hypomineralization Type
Amelogenesis Imperfecta Type Iii	Hypocalcified Amelogenesis Imperfecta
Amelogenesis Imperfecta, Type 3	Amelogenesis Imperfecta, Hypomineralization Type
Autosomal Dominant Amelogenesis Imperfecta Hypocalcification Type	Amelogenesis Imperfecta 3a
Amelogenesis Imperfecta Hypocalcification Type Autosomal Dominant

Filippi Syndrome

Scott Craniodigital Syndrome With Mental Retardation	Type 1 Syndactyly-Microcephaly-Intellectual Disability Syndrome
FLPIS	Scott Bryant Graham Syndrome
Craniodigital-Intellectual Disability Syndrome	Scott Craniodigital Syndrome
Scott-Bryant-Graham Syndrome	Syndactyly, Type I, With Microcephaly And Mental Retardation
Syndactyly Type I With Microcephaly And Intellectual Disability	Unusual Facial Appearance, Microcephaly, Growth And Intellectual Disability And Syndactyly
Craniodigital Syndrome With Intellectual Disability	Craniodigital Syndrome-Intellectual Disability Syndrome
Craniodigital Syndrome-Intellectual Disability, Scott Type	Intellectual Disability-Craniodigital Syndrome

Hepatocellular Carcinoma

Liver Cancer	Primary Liver Cancer
HCC	Hepatoma
Malignant Neoplasm Of Liver	Liver Neoplasms
Cancer, Hepatocellular	Liver Cell Carcinoma
Lcc	Hepatoblastoma, Somatic
Hepatic Cancer	Primary Malignant Neoplasm Of Liver
Rare Tumor Of Liver And Intrahepatic Biliary Tract	Hepatocellular Carcinoma, Somatic
Hepatocellular Carcinoma, Childhood Type, Somatic	Hepatocellular Cancer, Somatic
Ca Liver - Primary	Hepatic Neoplasm
Malignant Hepato-Biliary Neoplasm	Malignant Neoplasm Of Liver, Not Specified As Primary Or Secondary
Malignant Neoplasm Of Liver, Primary	Malignant Tumor Of Liver
Neoplasm Of Liver	Non-Resectable Primary Hepatic Malignant Neoplasm
Resectable Malignant Neoplasm Of Liver	Resectable Malignant Neoplasm Of The Liver
Primary Liver Carcinoma	Primary Malignant Liver Neoplasm
Primary Cancer Of Liver	Primary Tumor Of The Liver
Rare Tumor Of Liver And Ibt	Hepatocellular Cancer
Neoplasm Of The Liver	Carcinoma, Hepatocellular
Hepatomas	Liver Neoplasm
Liver Carcinoma	Liver And Intrahepatic Biliary Tract Carcinoma
Malignant Hepatobiliary Neoplasm	Adult Primary Hepatocellular Carcinoma
Hepatoblastoma	Carcinoma Of Liver
Malignant Liver Tumour	Malignant Hepatic Tumour

Breast Cancer

Breast Carcinoma	Male Breast Cancer
Breast Cancer, Familial	Malignant Neoplasm Of Breast
Breast Cancer, Susceptibility To	Breast Cancer, Early-Onset
Malignant Tumor Of Breast	Carcinoma Of Male Breast
Breast Cancer, Invasive Ductal	Breast Cancer, Protection Against
Breast Cancer, Somatic	Breast Cancer, Male
Breast Cancer, Lobular, Somatic	Breast Tumor
Mammary Cancer	Mammary Tumor
Malignant Neoplasm Of Male Breast	Mammary Carcinoma
Male Breast Carcinoma	Familial Cancer Of Breast
Invasive Ductal Breast Carcinoma	Breast Cancer Susceptibility
Breast Cancer, Male, Susceptibility To	Breast Cancer, Early-Onset, Susceptibility To
Malignant Tumor Of The Breast	Mammary Neoplasm
Primary Breast Cancer	Neoplasm Of Male Breast
Carcinoma Of Breast	Breast Cancer In Men
Familial Breast Cancer	Cancer Of Breast
BC	Breast Cancer Familial
Breast Cancer Familial Male	Breast Cancer, Familial Male
Breast Male Carcinoma	Breast Neoplasms
Breast Neoplasms, Male	Mammary Tumors
Mammary Carcinomas	Cancer, Breast
Cancer, Breast, Susceptibility	Invasive Breast Ductal Carcinoma
Breast Neoplasm	Susceptibility To Breast Cancer
Mammary Neoplasms	Animal Mammary Neoplasms
Primary Malignant Neoplasm Of Breast	Infiltrating Ductal Carcinoma Of Breast
Infiltrating Duct Carcinoma Of Unspecified Site	Infiltrating Ductular Carcinoma Of Unspecified Site
Invasive Breast Carcinoma Of No Special Type	Microinvasive Carcinoma Of Breast
Carcinoma With Apocrine Differentiation

疾病名称	别名
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Cat. No.	产品名	作用方式	纯度	是否罕见病
HY-RS04723	FAM83D Human Pre-designed siRNA Set A	Pre-designed Sets	/	否

直系同源

种属	基因名	来源	基因 ID
Bos taurus	FAM83D	VGNC	VGNC:28835
Mus musculus	FAM83D	MGD	MGI:1919128
Canis familiaris	FAM83D	VGNC	VGNC:40702
Felis catus	FAM83D	VGNC	VGNC:62130
Rattus norvegicus	FAM83D	RGD	RGD:1565583

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MedChemExpress (MCE) 只为有资质的科研机构、医药企业基于科学研究或药证申报的用途提供医药研发服务，不为任何个人或者非科研性质的、非用于药证申报使用等其他用途提供服务。

站点地图隐私声明

沪ICP备15051369号-4

上海工商

沪公网安备31011502019417

沪(浦)应急管危经许[2021]201709(QFYS)

营业执照（三证合一）

FAM83D - family with sequence similarity 83 member D Gene

关于 FAM83D

功能概要

FAM83D 基因产物(1)

FAM83D 蛋白结构

FAM83D 蛋白互作信息

关联疾病

直系同源

热门区域

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FAM83D - family with sequence similarity 83 member D Gene

关于 FAM83D

功能概要

FAM83D 基因产物(1)

FAM83D 蛋白结构

FAM83D 蛋白互作信息

关联疾病

相关产品

直系同源

热门区域

A

B

C

F

G

H

J

L

N

Q

S

T

X

Y

Z