1. Gene
  2. CSNK1A1 - casein kinase 1 alpha 1 Gene

CSNK1A1 - casein kinase 1 alpha 1 Gene

中文名称:酪蛋白激酶 1 α 1

种属: Homo sapiens

同用名: CK1; CK1a; CKIa; HLCDGP1; PRO2975; HEL-S-77p

基因 ID: 1452 | 基因类型: protein coding

关于 CSNK1A1

Cytogenetic location: 5q32 Genomic coordinates (GRCh38): 5:149,492,982-149,551,439 (from NCBI)

This gene has 17 transcripts (splice variants), 234 orthologues and 12 paralogues. Ubiquitous expression in esophagus (RPKM 69.2), gall bladder (RPKM 47.2) and 25 other tissues.

功能概要

启用蛋白质丝氨酸/苏氨酸激酶活性。参与多个过程,包括经典 Wnt 信号通路的负调控;肽基丝氨酸磷酸化;蛋白酶体泛素依赖性蛋白质分解代谢过程的正调控。位于中心体;胞质溶胶;和核斑点。 β-连环蛋白破坏复合体的一部分。与角蛋白丝和 mRNA 裂解以及聚腺苷酸化特异性因子复合物共定位。阿尔茨海默病和包涵体肌炎的生物标志物。 [由基因组资源联盟提供,2022 年 4 月]

Enables protein serine/threonine kinase activity. Involved in several processes, including negative regulation of canonical Wnt signaling pathway; peptidyl-serine phosphorylation; and positive regulation of proteasomal ubiquitin-dependent protein catabolic process. Located in centrosome; cytosol; and nuclear speck. Part of beta-catenin destruction complex. Colocalizes with keratin filament and mRNA cleavage and polyadenylation specificity factor complex. Biomarker of Alzheimer's disease and inclusion body myositis. [provided by Alliance of Genome Resources, Apr 2022]

CSNK1A1 基因产物(4)

mRNA Protein Name
NM_001025105.3 NP_001020276.1 casein kinase I isoform alpha isoform 1
NM_001271741.2 NP_001258670.1 casein kinase I isoform alpha isoform 3
NM_001271742.2 NP_001258671.1 casein kinase I isoform alpha isoform 4
NM_001892.6 NP_001883.4 casein kinase I isoform alpha isoform 2
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables protein binding IPI
IPI: 通过物理相互作用推断
16511560 GOA
enables protein serine/threonine kinase activity EXP
EXP: 通过实验结果推断
32645325 GOA
enables protein serine/threonine kinase activity IDA
IDA: 通过直接分析推断
18305108 GOA
enables protein serine/threonine kinase activity IMP
IMP: 通过突变表型推断
11955436 GOA
细胞组分 GO 注释 逻辑证据 参考文献 来源
part of beta-catenin destruction complex IDA
IDA: 通过直接分析推断
11955436 GOA
located in centrosome IDA
IDA: 通过直接分析推断
21399614 GOA
colocalizes with keratin filament IDA
IDA: 通过直接分析推断
23902688 GOA
part of mRNA cleavage and polyadenylation specificity factor complex IDA
IDA: 通过直接分析推断
18305108 GOA
located in nuclear speck IDA
IDA: 通过直接分析推断
18305108 GOA
EXP:通过实验结果推断 IDA:通过直接分析推断 IPI:通过物理相互作用推断 IMP:通过突变表型推断 IGI:通过遗传相互作用推断 IEP:通过表达模式推断

CSNK1A1 蛋白结构

Pkinase

Pkinase: Protein kinase domain (17 - 248)

  • 0
  • 100
  • 200
  • 300
  • 337 a.a.
蛋白主名 其他名称

casein kinase I isoform alpha

CKI-alpha

CSNK1A1 蛋白互作信息

分类
蛋白名称 蛋白编号 互作蛋白 互作蛋白种属 互作蛋白编号 实验方法 参考文献
Intra CSNK1A1 P48729 FAM83G Homo sapiens A6ND36
Anti Bait CoIP
29789297
Intra CSNK1A1 P48729 FAM83G Homo sapiens A6ND36
Anti Tag CoIP
35271311
Intra CSNK1A1 P48729 FAM83G Homo sapiens A6ND36
Pull Down
32707033
Intra CSNK1A1 P48729 FAM83G Homo sapiens A6ND36
Anti Tag CoIP
33961781
Intra CSNK1A1 P48729 FAM83G Homo sapiens A6ND36
IF
29789297
Intra CSNK1A1 P48729 FAM83G Homo sapiens A6ND36
TAP
23455922
Intra CSNK1A1 P48729 MALT1 Homo sapiens Q9UDY8
Anti Bait CoIP
19118383
Intra CSNK1A1 P48729 FAM83C Homo sapiens Q9BQN1
IF
29789297
Intra CSNK1A1 P48729 FAM83F Homo sapiens Q8NEG4
IF
29789297
Intra CSNK1A1 P48729 FAM83F Homo sapiens Q8NEG4
Anti Tag CoIP
29789297
Intra CSNK1A1 P48729 FAM83D Homo sapiens Q9H4H8
Anti Tag CoIP
29789297
Intra CSNK1A1 P48729 FAM83D Homo sapiens Q9H4H8
Anti Tag CoIP
33961781
Intra CSNK1A1 P48729 FAM83D Homo sapiens Q9H4H8
TAP
23455922
Intra CSNK1A1 P48729 FAM83D Homo sapiens Q9H4H8
IF
29789297
Intra CSNK1A1 P48729 FAM83D Homo sapiens Q9H4H8
Anti Tag CoIP
35271311
Intra CSNK1A1 P48729 FAM83H Homo sapiens Q6ZRV2
Anti Tag CoIP
33961781
Intra CSNK1A1 P48729 FAM83H Homo sapiens Q6ZRV2
TAP
23455922
Intra CSNK1A1 P48729 FAM83H Homo sapiens Q6ZRV2
Pull Down
32707033
Intra CSNK1A1 P48729 FAM83H Homo sapiens Q6ZRV2
Anti Tag CoIP
35271311
Intra CSNK1A1 P48729 FAM83H Homo sapiens Q6ZRV2
Anti Bait CoIP
29789297
Intra CSNK1A1 P48729 FAM83B Homo sapiens Q5T0W9
TAP
23455922
Intra CSNK1A1 P48729 FAM83B Homo sapiens Q5T0W9
Pull Down
32707033
Intra CSNK1A1 P48729 FAM83B Homo sapiens Q5T0W9
Anti Tag CoIP
35271311
Intra CSNK1A1 P48729 HSP90AB1 Homo sapiens P08238
Pull Down
32707033
Intra CSNK1A1 P48729 HSP90AB1 Homo sapiens P08238
Lumier
22939624
Intra CSNK1A1 P48729 RIPK1 Homo sapiens Q13546
Protein Kinase Assay
18067272
Intra CSNK1A1 P48729 RIPK1 Homo sapiens Q13546
Anti Tag CoIP
18067272
Intra CSNK1A1 P48729 MDM2 Homo sapiens Q00987
Anti Tag CoIP
20708156
Intra CSNK1A1 P48729 MDM2 Homo sapiens Q00987
Pull Down
20708156
Intra CSNK1A1 P48729 MDM4 Homo sapiens O15151
Affinity Chrom
17110929
Intra CSNK1A1 P48729 MDM4 Homo sapiens O15151
Anti Tag CoIP
16511560
Intra CSNK1A1 P48729 MDM4 Homo sapiens O15151
Anti Tag CoIP
35271311
Intra CSNK1A1 P48729 CARD11 Homo sapiens Q9BXL7
Anti Bait CoIP
19118383
种属间: 跨种属相互作用 种属内: 同种属相互作用

重组 CSNK1A1 蛋白

目录号 产品名 蛋白编号 纯度
HY-P72872 Casein Kinase I alpha Protein, Human (sf9, GST) P48729-1 (M1-F337) ≥95%

关联疾病

疾病名称 别名
Enterobiasis

Oxyuriasis

Pinworm Infection

Enterobius Vermicularis Infection

Threadworm Infection

Oxyuris Vermicularis Infection

Enterobiosis

Pinworm

Pinworm Disease

Seatworm Infection

Enterobiasis Threadworm

Pinworm Infestation

Seatworm

Amelogenesis Imperfecta, Type Iiia

Ai3

Adhcai

Amelogenesis Imperfecta Type 3

AI3A

Amelogenesis Imperfecta, Type Iii

Amelogenesis Imperfecta, Hypocalcification Type, Autosomal Dominant

Amelogenesis Imperfecta Type 3a

Amelogenesis Imperfecta Hypomineralization Type

Amelogenesis Imperfecta Type Iii

Hypocalcified Amelogenesis Imperfecta

Amelogenesis Imperfecta, Type 3

Amelogenesis Imperfecta, Hypomineralization Type

Autosomal Dominant Amelogenesis Imperfecta Hypocalcification Type

Amelogenesis Imperfecta 3a

Amelogenesis Imperfecta Hypocalcification Type Autosomal Dominant

Colorectal Cancer

Colon Cancer

Colorectal Carcinoma

Colon Carcinoma

Colorectal Cancer, Susceptibility To

Carcinoma Of Colon

CRC

Colorectal Cancer With Chromosomal Instability, Somatic

Colon Cancer, Somatic

Colon Cancer, Susceptibility To

Colonic Neoplasms

Colorectal Neoplasms

Colorectal Cancer, Somatic

Colon Cancer, Advanced, Somatic

Colonic Carcinoma

Colorectal Carcinomas

Colon Cancers

Colorectal Cancers

Cancer, Colorectal, Somatic

Cancer, Colon

Cancer, Colorectal, Susceptibility To

Colorectal Neoplasm

Colonic Neoplasm

Malignant Tumor Of Colon

Lung Cancer

Lung Carcinoma

Non-Small Cell Lung Carcinoma

Lung Cancer, Susceptibility To

Lung Cancer, Protection Against

Adenocarcinoma Of Lung, Somatic

Adenocarcinoma Of Lung, Response To Tyrosine Kinase Inhibitor In

Nonsmall Cell Lung Cancer

Lung Neoplasm

Carcinoma Of Lung

Lung Non-Small Cell Carcinoma

Non-Small Cell Lung Cancer

Nsclc

Lung Neoplasms

Malignant Neoplasm Of Lung

Alveolar Cell Carcinoma

Nonsmall Cell Lung Cancer, Somatic

Nonsmall Cell Lung Cancer, Response To Tyrosine Kinase Inhibitor In

Nonsmall Cell Lung Cancer, Susceptibility To

Lung Cancer, Somatic

Lung Cancer, Resistance To

Cancer Of Lung

Cancer Of Bronchus

Cancer Of The Lung

Lung Malignancies

Lung Malignant Tumors

Malignant Lung Tumor

Malignant Tumor Of Lung

Pulmonary Cancer

Pulmonary Carcinoma

Pulmonary Neoplasms

Respiratory Carcinoma

LNCR

Adenocarcinoma Of Lung

Neoplasm Of Lung

Cancer Lung

Carcinoma Non-Small Cell Lung

Carcinoma, Non-Small-Cell Lung

Lung Cancers

Lung Carcinomas

Cancer, Lung

Cancer, Lung, Non-Small Cell

Primary Malignant Neoplasm Of Lung

Bronchioloalveolar Adenocarcinoma

Hepatocellular Carcinoma

Liver Cancer

Primary Liver Cancer

HCC

Hepatoma

Malignant Neoplasm Of Liver

Liver Neoplasms

Cancer, Hepatocellular

Liver Cell Carcinoma

Lcc

Hepatoblastoma, Somatic

Hepatic Cancer

Primary Malignant Neoplasm Of Liver

Rare Tumor Of Liver And Intrahepatic Biliary Tract

Hepatocellular Carcinoma, Somatic

Hepatocellular Carcinoma, Childhood Type, Somatic

Hepatocellular Cancer, Somatic

Ca Liver - Primary

Hepatic Neoplasm

Malignant Hepato-Biliary Neoplasm

Malignant Neoplasm Of Liver, Not Specified As Primary Or Secondary

Malignant Neoplasm Of Liver, Primary

Malignant Tumor Of Liver

Neoplasm Of Liver

Non-Resectable Primary Hepatic Malignant Neoplasm

Resectable Malignant Neoplasm Of Liver

Resectable Malignant Neoplasm Of The Liver

Primary Liver Carcinoma

Primary Malignant Liver Neoplasm

Primary Cancer Of Liver

Primary Tumor Of The Liver

Rare Tumor Of Liver And Ibt

Hepatocellular Cancer

Neoplasm Of The Liver

Carcinoma, Hepatocellular

Hepatomas

Liver Neoplasm

Liver Carcinoma

Liver And Intrahepatic Biliary Tract Carcinoma

Malignant Hepatobiliary Neoplasm

Adult Primary Hepatocellular Carcinoma

Hepatoblastoma

Carcinoma Of Liver

Malignant Liver Tumour

Malignant Hepatic Tumour

Desmoid Tumor

Aggressive Fibromatosis

Desmoid Type Fibromatosis

Familial Infiltrative Fibromatosis

Desmoid Disorder, Hereditary

Fif

Fibromatosis, Familial Infiltrative

Deep Fibromatosis

Desmoid Fibromatosis

Hereditary Desmoid Disease

Musculoaponeurotic Fibromatosis

Desmoid-Type Fibromatosis

Fibromatosis, Aggressive

Desmoid Disease, Hereditary

Musculo-Aponeurotic Fibromatosis

Breast Cancer

Breast Carcinoma

Male Breast Cancer

Breast Cancer, Familial

Malignant Neoplasm Of Breast

Breast Cancer, Susceptibility To

Breast Cancer, Early-Onset

Malignant Tumor Of Breast

Carcinoma Of Male Breast

Breast Cancer, Invasive Ductal

Breast Cancer, Protection Against

Breast Cancer, Somatic

Breast Cancer, Male

Breast Cancer, Lobular, Somatic

Breast Tumor

Mammary Cancer

Mammary Tumor

Malignant Neoplasm Of Male Breast

Mammary Carcinoma

Male Breast Carcinoma

Familial Cancer Of Breast

Invasive Ductal Breast Carcinoma

Breast Cancer Susceptibility

Breast Cancer, Male, Susceptibility To

Breast Cancer, Early-Onset, Susceptibility To

Malignant Tumor Of The Breast

Mammary Neoplasm

Primary Breast Cancer

Neoplasm Of Male Breast

Carcinoma Of Breast

Breast Cancer In Men

Familial Breast Cancer

Cancer Of Breast

BC

Breast Cancer Familial

Breast Cancer Familial Male

Breast Cancer, Familial Male

Breast Male Carcinoma

Breast Neoplasms

Breast Neoplasms, Male

Mammary Tumors

Mammary Carcinomas

Cancer, Breast

Cancer, Breast, Susceptibility

Invasive Breast Ductal Carcinoma

Breast Neoplasm

Susceptibility To Breast Cancer

Mammary Neoplasms

Animal Mammary Neoplasms

Primary Malignant Neoplasm Of Breast

Infiltrating Ductal Carcinoma Of Breast

Infiltrating Duct Carcinoma Of Unspecified Site

Infiltrating Ductular Carcinoma Of Unspecified Site

Invasive Breast Carcinoma Of No Special Type

Microinvasive Carcinoma Of Breast

Carcinoma With Apocrine Differentiation

Autosomal Recessive Intellectual Developmental Disorder

Mental Retardation, Autosomal Recessive

Autosomal Recessive Mental Retardation

Autosomal Recessive Non-Syndromic Mental Retardation

Autosomal Recessive Non-Syndromic Intellectual Disability

疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

直系同源

种属 基因名 来源 基因 ID
Macaca mulatta CSNK1A1 VGNC VGNC:84290
Bos taurus CSNK1A1 VGNC VGNC:55205
Mus musculus CSNK1A1 MGD MGI:1934950
Felis catus CSNK1A1 VGNC VGNC:102183
Rattus norvegicus CSNK1A1 RGD RGD:71098
Others CSNK1A1 NCBI