1. Gene
  2. CARD11 - caspase recruitment domain family member 11 Gene

CARD11 - caspase recruitment domain family member 11 Gene

中文名称:胱天蛋白酶招募域家族成员 11

种属: Homo sapiens

同用名: PPBL; BENTA; BIMP3; IMD11; CARMA1; IMD11A

基因 ID: 84433 | 基因类型: protein coding

关于 CARD11

Cytogenetic location: 7p22.2 Genomic coordinates (GRCh38): 7:2,906,142-3,043,867 (from NCBI)

This gene has 8 transcripts (splice variants), 206 orthologues, 3 paralogues and is associated with 133 phenotypes. Biased expression in lymph node (RPKM 19.0), spleen (RPKM 15.1) and 10 other tissues.

功能概要

由该基因编码的蛋白质属于膜相关鸟苷酸激酶 (MAGUK) 家族,这是一类蛋白质,可作为分子支架在质膜的特定区域组装多蛋白复合物。该蛋白也是 CARD 蛋白家族的成员,该家族的定义是携带一个特征性半胱天冬酶相关募集结构域 (CARD) 。该蛋白具有与 CARD14 蛋白相似的结构域结构。这两种蛋白质的 CARD 结构域已显示与 BCL10 特异性相互作用,BCL10 是一种已知可作为细胞凋亡和 NF-kappaB 激活的正调节剂发挥作用的蛋白质。当在细胞中表达时,该蛋白激活 NF-kappaB 并诱导 BCL10 磷酸化。[RefSeq 提供,2008 年 7 月]

The protein encoded by this gene belongs to the membrane-associated guanylate kinase (MAGUK) family, a class of proteins that functions as molecular scaffolds for the assembly of multiprotein complexes at specialized regions of the plasma membrane. This protein is also a member of the CARD protein family, which is defined by carrying a characteristic caspase-associated recruitment domain (CARD). This protein has a domain structure similar to that of CARD14 protein. The CARD domains of both proteins have been shown to specifically interact with BCL10, a protein known to function as a positive regulator of cell Apoptosis and NF-kappaB activation. When expressed in cells, this protein activated NF-kappaB and induced the phosphorylation of BCL10. [provided by RefSeq, Jul 2008]

CARD11 基因产物(2)

mRNA Protein Name
NM_001324281.3 NP_001311210.1 caspase recruitment domain-containing protein 11
NM_032415.7 NP_115791.3 caspase recruitment domain-containing protein 11
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables CARD domain binding IPI
IPI: 通过物理相互作用推断
11278692 GOA
enables protein binding IPI
IPI: 通过物理相互作用推断
12154360 GOA
细胞组分 GO 注释 逻辑证据 参考文献 来源
part of CBM complex IDA
IDA: 通过直接分析推断
24074955 GOA
located in cytoplasm IDA
IDA: 通过直接分析推断
12154360 GOA
located in membrane raft IDA
IDA: 通过直接分析推断
12154360 GOA
located in plasma membrane IDA
IDA: 通过直接分析推断
12154360 GOA
EXP:通过实验结果推断 IDA:通过直接分析推断 IPI:通过物理相互作用推断 IMP:通过突变表型推断 IGI:通过遗传相互作用推断 IEP:通过表达模式推断

CARD11 蛋白结构

CARD

CARD: Caspase recruitment domain (23 - 108)

  • 0
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  • 1000
  • 1154 a.a.
蛋白主名 其他名称

caspase recruitment domain-containing protein 11

CARD-containing MAGUK protein 1

CARD11 蛋白互作信息

分类
蛋白名称 蛋白编号 互作蛋白 互作蛋白种属 互作蛋白编号 实验方法 参考文献
种属内
CARD11 Q9BXL7 CSNK1A1 Homo sapiens P48729-1 19118383
种属内
CARD11 Q9BXL7 MALT1 Homo sapiens Q9UDY8 17948050
种属内
CARD11 Q9BXL7 MALT1 Homo sapiens Q9UDY8 22528498
种属内
CARD11 Q9BXL7 CSNK1A1 Homo sapiens P48729 19118383
种属内
CARD11 Q9BXL7 CBLB Homo sapiens Q13191-1 19815501
种属间
CARD11 Q9BXL7 Map4k1 Mus musculus P70218 19706536
种属内
CARD11 Q9BXL7 PRKCD Homo sapiens Q05655 22528498
种属内
CARD11 Q9BXL7 PRKCD Homo sapiens Q05655 22528498
种属内
CARD11 Q9BXL7 PRKCD Homo sapiens Q05655 22528498
种属内
CARD11 Q9BXL7 PRKCD Homo sapiens Q05655
TAP
22528498
种属内
CARD11 Q9BXL7 BCL10 Homo sapiens O95999 19444310
种属内
CARD11 Q9BXL7 BCL10 Homo sapiens O95999 22528498
种属间: 跨种属相互作用 种属内: 同种属相互作用

CARD11 抗体

目录号 产品名 应用 反应物种
HY-P82870 CARD11 Antibody (YA2615) WB, ICC/IF Human, Mouse

关联疾病

疾病名称 别名
B-Cell Expansion With Nfkb And T-Cell Anergy

Benta Disease

BENTA

B-Cell Expansion With Nf-Kb And T-Cell Anergy Disease

Persistent Polyclonal B-Cell Lymphocytosis

Lymphocytosis

Immunodeficiency 11

Immunodeficiency 11a

Severe Combined Immunodeficiency Due To Card11 Deficiency

IMD11A

Imd11

Card11 Immunodeficiency

Scid Due To Card11 Deficiency

Card11 Deficiency

Immunodeficiency 11 A

Immunodeficiency 11b With Atopic Dermatitis

IMD11B

Atopic Dermatitis, Elevated Ige, And Eosinophilia

Immunodeficiency 11b

Splenomegaly
Asthma

Chronic Obstructive Asthma

Asthma, Diminished Response To Antileukotriene Treatment In

Bronchial Hyperreactivity

Asthma, Susceptibility To

Asthma, Bronchial

Asthma, Protection Against

Asthma, Nocturnal, Susceptibility To

Nocturnal Asthma

Asthma-Related Traits

Asthma-Related Traits, Susceptibility To

Asthma, Nocturnal

Chronic Obstructive Asthma With Acute Exacerbation

Chronic Obstructive Asthma With Status Asthmaticus

Exercise Induced Asthma

Exercise-Induced Asthma

Bronchial Asthma

Asthma, Exercise-Induced

Idiosyncratic Asthma

Unspecified Asthma With Acute Exacerbation

Asthma, Unspecified, With Stated Status Asthmaticus

Status Asthmaticus Nos

Acute Severe Asthma

Acute Severe Bronchial Asthma

Status Asthma

Status Post Asthmaticus

Persistent Polyclonal B-Cell Lymphocytosis

PPBL

Persistent Polyclonal B-Cell Lymphocytosis With Binucleated Lymphocytes

Lymphocytosis, B-Cell, Polyclonal, Persistent

Lymphoma, Mucosa-Associated Lymphoid Type

Malt Lymphoma

Gastric Lymphoma, Primary

Lymphoma, Malt, Somatic

Mucosa-Associated Lymphoid Tissue Lymphoma

Extranodal Marginal Zone B-Cell Lymphoma

MALTOMA

Marginal Zone B-Cell Lymphoma

Mucosa-Associated Lymphatic Tissue Lymphoma

Primary Gastric Lymphoma

Gastric Lymphoma

Familial Primary Gastric Lymphoma

Dermatitis

Eczema

Skin Inflammation

Inflammatory Dermatosis

Lymphoma

Lymphoid Cancer

Lymphomas

Lymphoid Cancers

Lymphoid Neoplasm

Lymphoma Nos

Nhl - [Non-Hodgkin Lymphoma]

Non-Hodgkin Lymphoma

Non-Hodgkin Lymphoma, Nos

Non-Hodgkin Malignant Lymphoma Nos

B-Cell Lymphoma

Lymphoma, B-Cell

B-Cell Lymphomas

B-Cell Lymphocytic Neoplasm

Lymphoma B-Cell

B-Cell Lymphoma Nos

Combined Immunodeficiency

Combined T Cell And B Cell Immunodeficiency

Congenital Combined Immunodeficiency

Syndrome With Combined Immunodeficiency

Combined T And B Cell Immunodeficiency

Combined Immunity Deficiency

Combined Immunodeficiency Syndrome

Combined T-Cell And B-Cell Immunodeficiency

Lymphopenic Agammaglobulinaemia

Primary Mediastinal B-Cell Lymphoma

Large Cell Lymphoma Of The Mediastinum

Mediastinal Diffuse Large-Cell Lymphoma With Sclerosis

Primary Mediastinal Clear Cell Lymphoma Of B-Cell Type

Colon Squamous Cell Carcinoma

Colonic Epidermoid Carcinoma

Squamous Cell Carcinoma Of Colon

Squamous Cell Carcinoma Of The Colon

Marginal Zone B-Cell Lymphoma

Marginal Zone Lymphoma

Mzl

Mucosa-Associated Lymphoid Tissue Lymphoma

Central Nervous System Lymphoma

Microglioma

Primary Cns Lymphoma

Cns Lymphoma

Primary Central Nervous System Lymphoma

Central Nervous System Hematologic Cancer

Cns Hematopoietic Tumor

Hematopoietic Neoplasm Of Central Nervous System

Central Nervous System Hematopoietic Neoplasm

Common Variable Immunodeficiency

Cvid

Common Variable Agammaglobulinemia

Common Variable Immune Deficiency

Acquired Hypogammaglobulinemia

Hypogamma-Globulinemia, Acquired

Idiopathic Immunoglobulin Deficiency

Primary Antibody Deficiency

Primary Hypogammaglobulinemia

Acquired Agammaglobulinemia

Sporadic Hypogammaglobulinemia

Common Variable Hypogamma-Globulinemia

Immunoglobulin Deficiency, Late-Onset

Common Variable Hypogammaglobulinemia

Immunodeficiency, Common Variable

Colorectal Adenocarcinoma

Adenocarcinoma Of Large Intestine

Severe Combined Immunodeficiency

Scid

Severe Combined Immunodeficiency Disease

Combined T And B Cell Inborn Immunodeficiency

Immunodeficiency, Severe Combined

Scid - [Severe Combined Immunodeficiencies]

St2 Diffuse Large B-Cell Lymphoma

St2 Dlbcl

Doid:0081068

Testicular Lymphoma

Malignant Lymphoma Of Testis

Lymphoma Of The Testis

Spleen Cancer

Spleen Neoplasm

Splenic Neoplasm

Splenic Neoplasms

Malignant Splenic Tumor

Malignant Tumour Of Spleen

Tumor Of Spleen

Malignant Neoplasm Of Spleen

T-Cell Adult Acute Lymphocytic Leukemia

Acute Adult T-Cell Leukemia-Lymphoma

Adult Precursor T Lymphoblastic Leukemia

Atll

T-Cell Adult Acute Lymphoblastic Leukemia

Splenic Marginal Zone Lymphoma

Smzl

Splenic Marginal Zone B-Cell Lymphoma

Lymphoplasmacytic Lymphoma

Waldenstrom Macroglobulinemia

Malignant Lymphoma - Lymphoplasmacytic

Waldenström Macroglobulinaemia

Waldenström Macroglobulinaemia Without Mention Of Remission

Idiopathic Macroglobulinaemia

Primary Macroglobulinaemia

Ezb Diffuse Large B-Cell Lymphoma

Ezb Dlbcl

Doid:0081065

Immunodeficiency 58

IMD58

Severe Combined Immunodeficiency Due To Carmil2 Deficiency

Combined Immunodeficiency Due To Carmil2 Deficiency

Combined Immunodeficiency Due To Rltpr Deficiency

Ras-Associated Autoimmune Leukoproliferative Disorder

RALD

Autoimmune Lymphoproliferative Syndrome Type 4

Alps4

Autoimmune Lymphoproliferative Syndrome, Type Iv

Ras-Associated Autoimmune Leukoproliferative Disease

Ras-Associated Autoimmune Lymphoproliferative Syndrome Type Iv, Somatic

Alps Type 4

Alps Type Iv

Autoimmune Lymphoproliferative Syndrome Type Iv

Autoimmune Lymphoproliferative Syndrome 4

Pityriasis Rubra Pilaris

PRP

Devergie'S Disease

Prp - [Pityriasis Rubra Pilaris]

Adult T-Cell Leukemia/Lymphoma

Adult T-Cell Leukemia

Atll

Adult T-Cell Leukaemia

Adult T-Cell Leukaemia/Lymphoma

Adult T-Cell Lymphoma

T Cell Leukemia Lymphoma Adult

Leukemia-Lymphoma, Adult T-Cell

Leukemia, T-Cell

Adult T-Cell Lymphoma/Leukemia

Mantle Cell Lymphoma

Lymphoma, Mantle Cell

Lcm

Mcl

Mantle Zone Lymphoma

Lymphoma Mantle-Cell

Lymphoma, Mantle-Cell

Malignant Lymphoma, Lymphocytic, Intermediate Differentiation, Diffuse

Malignant Lymphoma - Lymphocytic, Intermediate Differentiation

Diffuse Small Cleaved-Cell Lymphoma

Diffuse Small Cleaved Cell Malignant Lymphoma

Small Cleaved Cell Non-Hodgkin Lymphoma

Diffuse Non-Hodgkin Small Cleaved Cell Lymphoma

Malignant Lymphomatous Polyposis

Malignant Small Cell, Noncleaved, Diffuse Lymphoma

Malignant Undifferentiated Cell, Non-Burkitt Lymphoma

Cleaved Cell Lymphoma

Small Cell Mantle Cell Lymphoma

Small Cleaved Cell Malignant Lymphoma

Sezary'S Disease

Sezary Syndrome

Sézary Syndrome

Sezary'S Lymphoma

Sezary Disease

Sezary Erythroderma

Sezary Lymphoma

Omenn Syndrome

Histiocytic Medullary Reticulosis

Severe Combined Immunodeficiency With Hypereosinophilia

Combined Immunodeficiency With Hypereosinophilia

Reticuloendotheliosis, Familial, With Eosinophilia

Reticuloendotheliosis Familial With Eosinophilia

Familial Reticuloendotheliosis

Omenn'S Syndrome

OS

Malignant Histiocytosis

Diffuse Large B-Cell Lymphoma

Dlbcl

Diffuse Large B-Cell Lymphoma, Not Otherwise Specified

Large B-Cell Diffuse Lymphoma

Lymphoma, Large B-Cell, Diffuse

Dlbcl - [Diffuse Large B-Cell Lymphoma]

Diffuse Large Beta Cell Lymphoma

Autoimmune Lymphoproliferative Syndrome

ALPS

Canale-Smith Syndrome

Autoimmune Lymphoproliferative Syndrome, Type Ia

Autoimmune Lymphoproliferative Syndrome, Type Ib

Autoimmune Lymphoproliferative Syndrome Type 1, Autosomal Dominant

Css

Autoimmune Lymphoproliferative Syndrome, Type 1b

Autoimmune Lymphoproliferative Syndrome, Type 1a

Autoimmune Lymphoproliferative Syndrome, Type I, Autosomal Dominant

Fas Deficiency

Autoimmune Lymphoproliferative Syndrome 1a

ALPS1A

Autoimmune Lymphoproliferative Syndrome Type Ia

Autoimmune Lymphoproliferative Syndrome 1b

ALPS1B

Autoimmune Lymphoproliferative Syndrome Type Ib

Lymphoma, Non-Hodgkin, Familial

Non-Hodgkin Lymphoma

Lymphoma, Non-Hodgkin

NHL

Lymphoma, Non-Hodgkin, Somatic

Lymphoma, Follicular, Somatic

Familial Non-Hodgkin Lymphoma

Lymphoma Non-Hodgkins

Follicular Lymphoma, Somatic

Lymphosarcoma

Non-Hodgkins Lymphoma

Leukemia, Chronic Lymphocytic

Chronic Lymphocytic Leukemia

B-Cell Chronic Lymphocytic Leukemia

CLL

B-Cell Chronic Lymphoid Leukemia

Chronic Lymphatic Leukemia

Chronic Lymphocytic Leukaemia

Lymphoplasmacytic Leukemia

Small Lymphocytic Lymphoma

Leukemia, Chronic Lymphatic

B-Cell Chronic Lymphocytic Leukaemia

Chronic Lymphatic Leukaemia

Lymphoplasmacytic Leukaemia

B Cell Chronic Lymphocytic Leukemia

Chronic B-Cell Lymphocytic Leukemia

Leukemia, Lymphocytic, Chronic

B-Cll

Chronic Lymphoid Leukemia

Leukemia Lymphocytic Chronic

Lymphoma Small Lymphocytic

Leukemia, Lymphocytic, Chronic, B-Cell

疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

直系同源

种属 基因名 来源 基因 ID
Rattus norvegicus CARD11 RGD RGD:2323211
Macaca mulatta CARD11 VGNC VGNC:70568
Felis catus CARD11 VGNC VGNC:60364
Bos taurus CARD11 VGNC VGNC:26761
Mus musculus CARD11 MGD MGI:1916978
Canis familiaris CARD11 VGNC VGNC:38714
Others CARD11 NCBI